Motif ID: Cenpb

Z-value: 1.481


Transcription factors associated with Cenpb:

Gene SymbolEntrez IDGene Name
Cenpb ENSMUSG00000068267.4 Cenpb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Cenpbmm10_v2_chr2_-_131179985_131180092-0.371.3e-01Click!


Activity profile for motif Cenpb.

activity profile for motif Cenpb


Sorted Z-values histogram for motif Cenpb

Sorted Z-values for motif Cenpb



Network of associatons between targets according to the STRING database.



First level regulatory network of Cenpb

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_98662227 20.054 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr2_+_172550991 6.886 ENSMUST00000170744.1
 Tfap2c
transcription factor AP-2, gamma
chr8_-_87959560 6.172 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr13_+_48261427 4.525 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr1_-_138848576 4.405 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9
chr7_-_137314394 4.268 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr9_-_8004585 3.527 ENSMUST00000086580.5
ENSMUST00000065353.6
 Yap1

yes-associated protein 1

chr5_-_99037342 2.989 ENSMUST00000161490.1
 Prkg2
protein kinase, cGMP-dependent, type II
chr16_-_17125106 2.883 ENSMUST00000093336.6
 2610318N02Rik
RIKEN cDNA 2610318N02 gene
chr8_-_25201349 2.841 ENSMUST00000084512.4
ENSMUST00000084030.4
 Tacc1

transforming, acidic coiled-coil containing protein 1

chr12_-_45074112 2.814 ENSMUST00000120531.1
ENSMUST00000143376.1
 Stxbp6

syntaxin binding protein 6 (amisyn)

chr11_+_101316917 2.741 ENSMUST00000151385.1
 Psme3
proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki)
chr6_+_66535418 2.712 ENSMUST00000101343.1
 Mad2l1
MAD2 mitotic arrest deficient-like 1
chr14_+_65805832 2.692 ENSMUST00000022612.3
 Pbk
PDZ binding kinase
chr6_-_94700137 2.508 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr10_+_25359798 2.336 ENSMUST00000053748.8
 Epb4.1l2
erythrocyte protein band 4.1-like 2
chr14_-_15438974 2.304 ENSMUST00000055211.4
 Lrrc3b
leucine rich repeat containing 3B
chr17_+_87282880 2.282 ENSMUST00000041110.5
ENSMUST00000125875.1
 Ttc7

tetratricopeptide repeat domain 7

chr2_+_168081004 2.192 ENSMUST00000052125.6
 Pard6b
par-6 (partitioning defective 6) homolog beta (C. elegans)
chr12_+_59013379 2.156 ENSMUST00000021379.7
 Gemin2
gem (nuclear organelle) associated protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 6.9 GO:0060598 dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598)
0.1 4.7 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
0.4 4.6 GO:0051601 exocyst localization(GO:0051601)
1.1 4.5 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.9 4.4 GO:0035262 gonad morphogenesis(GO:0035262)
0.6 3.5 GO:0060242 contact inhibition(GO:0060242)
0.1 3.5 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.3 3.3 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.4 3.0 GO:2001225 cellular hypotonic response(GO:0071476) regulation of chloride transport(GO:2001225)
0.0 2.9 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.9 2.8 GO:0021972 corticospinal neuron axon guidance through spinal cord(GO:0021972) positive regulation of negative chemotaxis(GO:0050924) induction of negative chemotaxis(GO:0050929) negative regulation of mononuclear cell migration(GO:0071676) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.1 2.8 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.3 2.7 GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.3 2.6 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.8 2.5 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 2.4 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.1 2.3 GO:0018345 protein palmitoylation(GO:0018345)
0.1 2.3 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.1 2.2 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 2.2 GO:0007043 cell-cell junction assembly(GO:0007043)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.6 GO:0000145 exocyst(GO:0000145)
0.3 4.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 4.4 GO:0005643 nuclear pore(GO:0005643)
1.2 3.5 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.2 3.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.7 2.7 GO:0008537 proteasome activator complex(GO:0008537)
0.0 2.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 2.6 GO:0042555 MCM complex(GO:0042555)
0.1 2.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 2.2 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.7 2.1 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 2.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 2.0 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.9 GO:0005839 proteasome core complex(GO:0005839)
0.1 1.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.7 GO:0000800 lateral element(GO:0000800)
0.0 1.6 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.5 GO:0005657 replication fork(GO:0005657)
0.2 1.2 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.3 5.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 5.5 GO:0005509 calcium ion binding(GO:0005509)
0.1 4.0 GO:0070064 proline-rich region binding(GO:0070064)
0.3 3.4 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 3.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.7 3.0 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.3 2.8 GO:0048495 GTPase inhibitor activity(GO:0005095) Roundabout binding(GO:0048495)
0.0 2.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 2.7 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 2.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 2.3 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.5 2.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.1 2.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 2.1 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 2.0 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.9 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 1.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 1.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 1.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.0 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 4.9 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 3.1 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.8 PID_GLYPICAN_1PATHWAY Glypican 1 network
0.1 2.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 2.4 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 1.8 PID_P53_REGULATION_PATHWAY p53 pathway
0.0 1.7 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 1.7 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.2 1.5 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 0.9 PID_ALK2_PATHWAY ALK2 signaling events
0.1 0.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.9 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.7 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.7 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.6 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.5 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.5 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 0.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.7 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.3 4.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 3.7 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 3.6 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.1 3.5 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 3.3 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 3.0 REACTOME_TETRAHYDROBIOPTERIN_BH4_SYNTHESIS_RECYCLING_SALVAGE_AND_REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 2.9 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.2 2.8 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.7 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.2 2.5 REACTOME_SIGNALING_BY_EGFR_IN_CANCER Genes involved in Signaling by EGFR in Cancer
0.1 2.0 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.9 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.7 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 1.5 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 1.2 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.0 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 1.0 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.0 REACTOME_TRANSLATION Genes involved in Translation
0.1 0.9 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex