Motif ID: Erg

Z-value: 1.598


Transcription factors associated with Erg:

Gene SymbolEntrez IDGene Name
Erg ENSMUSG00000040732.12 Erg

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ergmm10_v2_chr16_-_95459245_954593840.087.5e-01Click!


Activity profile for motif Erg.

activity profile for motif Erg


Sorted Z-values histogram for motif Erg

Sorted Z-values for motif Erg



Network of associatons between targets according to the STRING database.



First level regulatory network of Erg

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_5593566 3.991 ENSMUST00000160910.1
 Zeb1
zinc finger E-box binding homeobox 1
chr7_+_75701965 3.495 ENSMUST00000094307.3
 Akap13
A kinase (PRKA) anchor protein 13
chr16_-_38713235 3.433 ENSMUST00000023487.4
 Arhgap31
Rho GTPase activating protein 31
chr1_+_132008285 3.132 ENSMUST00000146432.1
 Elk4
ELK4, member of ETS oncogene family
chr2_+_163602331 2.922 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr5_+_75152274 2.868 ENSMUST00000000476.8
 Pdgfra
platelet derived growth factor receptor, alpha polypeptide
chrX_+_110814390 2.841 ENSMUST00000078229.3
 Pou3f4
POU domain, class 3, transcription factor 4
chrX_-_143933089 2.835 ENSMUST00000087313.3
 Dcx
doublecortin
chr1_-_56969827 2.756 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr11_+_83302817 2.752 ENSMUST00000142680.1
 Ap2b1
adaptor-related protein complex 2, beta 1 subunit
chr9_-_54661666 2.742 ENSMUST00000128624.1
 Acsbg1
acyl-CoA synthetase bubblegum family member 1
chr1_+_34005872 2.455 ENSMUST00000182296.1
 Dst
dystonin
chr10_-_68278713 2.370 ENSMUST00000020106.7
 Arid5b
AT rich interactive domain 5B (MRF1-like)
chr11_+_60777525 2.253 ENSMUST00000056907.6
ENSMUST00000102667.3
 Smcr8

Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)

chr10_-_58675631 2.233 ENSMUST00000003312.4
 Edar
ectodysplasin-A receptor
chr15_-_64382908 2.227 ENSMUST00000177374.1
ENSMUST00000023008.9
ENSMUST00000110115.2
ENSMUST00000110114.3
 Asap1



ArfGAP with SH3 domain, ankyrin repeat and PH domain1



chr6_-_122340200 2.162 ENSMUST00000159384.1
 Phc1
polyhomeotic-like 1 (Drosophila)
chr17_+_88626549 2.060 ENSMUST00000163588.1
ENSMUST00000064035.6
 Ston1

stonin 1

chr15_-_64382736 1.983 ENSMUST00000176384.1
ENSMUST00000175799.1
 Asap1

ArfGAP with SH3 domain, ankyrin repeat and PH domain1

chr15_-_103215285 1.978 ENSMUST00000122182.1
ENSMUST00000108813.3
ENSMUST00000127191.1
 Cbx5


chromobox 5



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 194 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 6.1 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 5.7 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.6 5.4 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.3 4.6 GO:0097152 mesenchymal cell apoptotic process(GO:0097152)
0.1 4.5 GO:0006611 protein export from nucleus(GO:0006611)
0.8 4.2 GO:1903527 positive regulation of membrane tubulation(GO:1903527)
0.1 4.2 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.3 3.6 GO:0042572 retinol metabolic process(GO:0042572)
0.2 3.6 GO:0070932 histone H3 deacetylation(GO:0070932)
0.2 3.6 GO:0008090 retrograde axonal transport(GO:0008090)
0.6 3.5 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0 3.5 GO:0046847 filopodium assembly(GO:0046847)
0.1 3.4 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 3.4 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 3.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.8 3.2 GO:1903966 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.2 3.1 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 3.1 GO:0070207 protein homotrimerization(GO:0070207)
0.1 3.0 GO:0071300 cellular response to retinoic acid(GO:0071300)
1.0 2.9 GO:0035790 platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 84 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 7.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 6.7 GO:0005902 microvillus(GO:0005902)
0.1 6.0 GO:0002102 podosome(GO:0002102)
0.1 4.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 3.2 GO:0010369 chromocenter(GO:0010369)
0.0 3.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 2.6 GO:0001739 sex chromatin(GO:0001739)
0.6 2.5 GO:0031673 H zone(GO:0031673)
0.0 2.5 GO:0030426 growth cone(GO:0030426)
0.6 2.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 2.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.3 2.3 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 2.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 2.2 GO:0032584 growth cone membrane(GO:0032584)
0.1 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.1 GO:0001650 fibrillar center(GO:0001650)
0.1 2.0 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.2 1.7 GO:0042587 glycogen granule(GO:0042587)
0.1 1.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 127 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.2 GO:0003682 chromatin binding(GO:0003682)
0.0 8.0 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 6.3 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 6.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 5.3 GO:0051015 actin filament binding(GO:0051015)
0.5 5.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 4.6 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 4.3 GO:0008017 microtubule binding(GO:0008017)
0.5 3.6 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 3.6 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.0 3.6 GO:0030276 clathrin binding(GO:0030276)
0.0 3.6 GO:0017124 SH3 domain binding(GO:0017124)
0.7 3.4 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.8 3.2 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.2 3.0 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 2.8 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.6 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 2.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 2.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 2.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.8 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.2 4.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.1 4.2 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 3.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.1 3.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.1 3.0 PID_REELIN_PATHWAY Reelin signaling pathway
0.1 2.9 PID_ATR_PATHWAY ATR signaling pathway
0.1 2.6 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.4 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.1 2.4 PID_GMCSF_PATHWAY GMCSF-mediated signaling events
0.0 2.2 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 2.0 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.0 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 1.7 PID_FGF_PATHWAY FGF signaling pathway
0.0 1.6 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 1.4 PID_E2F_PATHWAY E2F transcription factor network
0.1 1.2 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 1.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 50 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.9 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.2 4.5 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 3.3 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 3.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 3.1 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.7 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.7 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 2.3 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 2.2 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.1 2.2 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 2.0 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.1 2.0 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 1.8 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.1 1.7 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.6 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.5 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.1 1.3 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.1 1.2 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 1.2 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 1.2 REACTOME_TRANSPORT_OF_VITAMINS_NUCLEOSIDES_AND_RELATED_MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules