Motif ID: Hdx

Z-value: 8.725


Transcription factors associated with Hdx:

Gene SymbolEntrez IDGene Name
Hdx ENSMUSG00000034551.6 Hdx

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hdxmm10_v2_chrX_-_111697069_111697127-0.262.9e-01Click!


Activity profile for motif Hdx.

activity profile for motif Hdx


Sorted Z-values histogram for motif Hdx

Sorted Z-values for motif Hdx



Network of associatons between targets according to the STRING database.



First level regulatory network of Hdx

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 100 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3017408 205.294 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr9_+_3015654 180.482 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3023547 174.293 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3005125 163.829 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3034599 155.040 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3000922 152.237 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr9_+_3027439 145.343 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3025417 132.738 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr14_-_19418930 121.669 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3018753 112.034 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3004457 103.950 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3036877 98.180 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3037111 91.485 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3013140 82.646 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr2_-_98667264 60.991 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr6_-_23248264 36.138 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr16_-_26989974 14.608 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr6_+_30568367 10.099 ENSMUST00000049251.5
 Cpa4
carboxypeptidase A4
chr4_-_97584605 9.487 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr4_-_97584612 9.287 ENSMUST00000107068.2
 E130114P18Rik
RIKEN cDNA E130114P18 gene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1161.3 GO:0008150 biological_process(GO:0008150)
6.0 36.1 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.4 14.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.4 14.6 GO:0006270 DNA replication initiation(GO:0006270)
3.6 10.7 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.3 10.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 8.1 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.1 8.0 GO:0021884 forebrain neuron development(GO:0021884)
1.1 5.7 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.8 5.3 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
0.7 5.1 GO:0006344 maintenance of chromatin silencing(GO:0006344)
1.0 5.0 GO:0019659 fermentation(GO:0006113) lactate biosynthetic process from pyruvate(GO:0019244) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.7 5.0 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
1.2 4.9 GO:0006166 purine ribonucleoside salvage(GO:0006166)
0.2 4.6 GO:0043486 histone exchange(GO:0043486)
0.2 4.5 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.5 4.3 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 3.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 3.0 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.2 2.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)

Gene overrepresentation in cellular_component category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1247.8 GO:0005575 cellular_component(GO:0005575)
0.7 10.7 GO:0042101 T cell receptor complex(GO:0042101)
0.3 10.6 GO:0000788 nuclear nucleosome(GO:0000788)
1.3 8.1 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.3 8.0 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 7.6 GO:0005876 spindle microtubule(GO:0005876)
0.2 5.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.3 5.1 GO:0071564 npBAF complex(GO:0071564)
0.5 5.0 GO:0001739 sex chromatin(GO:0001739)
0.4 5.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 3.5 GO:0031105 septin complex(GO:0031105)
0.5 2.0 GO:0032021 NELF complex(GO:0032021)
0.1 1.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.3 1.1 GO:0060187 cell pole(GO:0060187)
0.3 0.9 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 0.8 GO:0005638 lamin filament(GO:0005638)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1177.6 GO:0003674 molecular_function(GO:0003674)
0.2 36.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 14.8 GO:0044325 ion channel binding(GO:0044325)
1.5 10.7 GO:1901612 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.2 10.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 9.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.2 8.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.4 7.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.4 5.7 GO:0003680 AT DNA binding(GO:0003680)
1.8 5.3 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.3 5.2 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.2 5.1 GO:0031491 nucleosome binding(GO:0031491)
1.2 5.0 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.7 5.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.6 4.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
0.1 4.6 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.2 4.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 4.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 3.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 2.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 4.6 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.2 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 1.9 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.0 1.8 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.6 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.9 ST_STAT3_PATHWAY STAT3 Pathway
0.0 0.8 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 10.6 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 5.7 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 5.0 REACTOME_PYRUVATE_METABOLISM Genes involved in Pyruvate metabolism
0.3 4.9 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.2 4.6 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling
0.2 4.5 REACTOME_OTHER_SEMAPHORIN_INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.0 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.5 REACTOME_ENOS_ACTIVATION_AND_REGULATION Genes involved in eNOS activation and regulation
0.2 2.2 REACTOME_PROLACTIN_RECEPTOR_SIGNALING Genes involved in Prolactin receptor signaling
0.0 2.1 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.6 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.1 0.9 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 0.7 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.6 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.5 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo