Motif ID: Foxi1_Foxo1

Z-value: 2.498

Transcription factors associated with Foxi1_Foxo1:

Gene SymbolEntrez IDGene Name
Foxi1 ENSMUSG00000047861.2 Foxi1
Foxo1 ENSMUSG00000044167.5 Foxo1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxo1mm10_v2_chr3_+_52268337_52268388-0.446.7e-02Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Foxi1_Foxo1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 26.894 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr17_-_70851710 19.715 ENSMUST00000166395.2
Tgif1
TGFB-induced factor homeobox 1
chr16_-_22161450 9.413 ENSMUST00000115379.1
Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr17_+_29090969 9.105 ENSMUST00000119901.1
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr18_+_20665250 8.712 ENSMUST00000075312.3
Ttr
transthyretin
chr16_+_30065333 7.884 ENSMUST00000023171.7
Hes1
hairy and enhancer of split 1 (Drosophila)
chr10_-_92165159 7.864 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr10_-_92162753 7.614 ENSMUST00000182197.1
Rmst
rhabdomyosarcoma 2 associated transcript (non-coding RNA)
chr4_-_97584605 7.289 ENSMUST00000107067.1
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr3_+_134236483 7.257 ENSMUST00000181904.1
ENSMUST00000053048.9
Cxxc4

CXXC finger 4

chr12_+_109452833 7.196 ENSMUST00000056110.8
Dlk1
delta-like 1 homolog (Drosophila)
chr11_+_32276400 7.153 ENSMUST00000020531.2
Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr14_+_73237891 7.106 ENSMUST00000044405.6
Lpar6
lysophosphatidic acid receptor 6
chr4_-_97584612 7.004 ENSMUST00000107068.2
E130114P18Rik
RIKEN cDNA E130114P18 gene
chr3_-_52104891 7.002 ENSMUST00000121440.1
Maml3
mastermind like 3 (Drosophila)
chr7_-_103853199 7.001 ENSMUST00000033229.3
Hbb-y
hemoglobin Y, beta-like embryonic chain
chr4_+_65124174 6.934 ENSMUST00000084501.3
Pappa
pregnancy-associated plasma protein A
chr9_+_78615501 6.922 ENSMUST00000093812.4
Cd109
CD109 antigen
chr5_-_138170992 6.845 ENSMUST00000139983.1
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
chr18_-_47333311 6.649 ENSMUST00000126684.1
ENSMUST00000156422.1
Sema6a

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A


Gene overrepresentation in biological_process category:

Showing 1 to 20 of 490 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 26.9 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.1 20.3 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
1.2 19.7 GO:0038092 nodal signaling pathway(GO:0038092)
1.7 16.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
2.8 14.2 GO:0015671 oxygen transport(GO:0015671)
1.5 13.1 GO:0071493 cellular response to UV-B(GO:0071493)
1.2 12.8 GO:0060539 diaphragm development(GO:0060539)
0.5 12.0 GO:0006270 DNA replication initiation(GO:0006270)
3.6 10.9 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
1.2 10.5 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.6 10.5 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.6 9.7 GO:0051451 myoblast migration(GO:0051451)
0.4 9.3 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.4 9.3 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.3 9.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 8.8 GO:1904355 positive regulation of telomere capping(GO:1904355)
1.7 8.7 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 8.7 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
2.6 7.9 GO:0021557 oculomotor nerve development(GO:0021557)
0.2 7.7 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 217 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 27.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 23.3 GO:0005615 extracellular space(GO:0005615)
1.3 19.7 GO:0042555 MCM complex(GO:0042555)
4.4 13.2 GO:0070557 PCNA-p21 complex(GO:0070557)
1.1 12.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.5 11.9 GO:0005833 hemoglobin complex(GO:0005833)
0.2 11.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 10.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 9.6 GO:0005902 microvillus(GO:0005902)
0.0 9.3 GO:0016607 nuclear speck(GO:0016607)
1.8 9.1 GO:0097149 centralspindlin complex(GO:0097149)
0.1 7.9 GO:0005871 kinesin complex(GO:0005871)
0.2 7.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 6.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 6.5 GO:0005681 spliceosomal complex(GO:0005681)
0.1 6.4 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.1 6.3 GO:0001674 female germ cell nucleus(GO:0001674)
1.0 6.3 GO:0031262 Ndc80 complex(GO:0031262)
0.1 6.3 GO:0030118 clathrin coat(GO:0030118)
0.1 5.7 GO:0000776 kinetochore(GO:0000776)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 329 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 33.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
1.1 29.3 GO:0008432 JUN kinase binding(GO:0008432)
0.5 20.8 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.5 19.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.5 16.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 15.2 GO:0003735 structural constituent of ribosome(GO:0003735)
2.8 14.2 GO:0005344 oxygen transporter activity(GO:0005344)
4.4 13.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
3.6 10.9 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.4 10.0 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 9.7 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
1.3 9.3 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.5 9.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.5 8.5 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.5 8.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.8 7.8 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
1.5 7.7 GO:0004594 pantothenate kinase activity(GO:0004594)
0.3 7.7 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.3 7.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 6.8 GO:0017049 GTP-Rho binding(GO:0017049)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 45.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.6 25.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 18.3 PID_ATR_PATHWAY ATR signaling pathway
0.3 15.1 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
1.5 13.2 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 11.0 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.7 10.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 10.1 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.2 10.0 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 9.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 9.7 PID_AP1_PATHWAY AP-1 transcription factor network
0.2 8.2 PID_PLK1_PATHWAY PLK1 signaling events
0.3 7.9 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 6.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 5.8 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 5.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.9 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.1 4.7 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.1 4.6 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 4.4 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 117 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 36.4 REACTOME_G1_PHASE Genes involved in G1 Phase
0.3 28.4 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
1.3 20.1 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.6 19.4 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.8 12.4 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.3 11.3 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.2 10.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.6 10.4 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 10.3 REACTOME_AMYLOIDS Genes involved in Amyloids
1.1 9.9 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 9.4 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 9.3 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 8.9 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.5 8.1 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 7.8 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.5 7.7 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 7.5 REACTOME_MRNA_SPLICING Genes involved in mRNA Splicing
0.5 6.9 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 6.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 6.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions