Motif ID: Foxi1_Foxo1
Z-value: 2.498
Transcription factors associated with Foxi1_Foxo1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Foxi1 | ENSMUSG00000047861.2 | Foxi1 |
Foxo1 | ENSMUSG00000044167.5 | Foxo1 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Foxo1 | mm10_v2_chr3_+_52268337_52268388 | -0.44 | 6.7e-02 | Click! |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 490 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
4.5 | 26.9 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
1.1 | 20.3 | GO:0030213 | hyaluronan biosynthetic process(GO:0030213) |
1.2 | 19.7 | GO:0038092 | nodal signaling pathway(GO:0038092) |
1.7 | 16.7 | GO:0006268 | DNA unwinding involved in DNA replication(GO:0006268) |
2.8 | 14.2 | GO:0015671 | oxygen transport(GO:0015671) |
1.5 | 13.1 | GO:0071493 | cellular response to UV-B(GO:0071493) |
1.2 | 12.8 | GO:0060539 | diaphragm development(GO:0060539) |
0.5 | 12.0 | GO:0006270 | DNA replication initiation(GO:0006270) |
3.6 | 10.9 | GO:0045819 | plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819) |
1.2 | 10.5 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
0.6 | 10.5 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
0.6 | 9.7 | GO:0051451 | myoblast migration(GO:0051451) |
0.4 | 9.3 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
0.4 | 9.3 | GO:0040034 | regulation of development, heterochronic(GO:0040034) |
0.3 | 9.3 | GO:0034723 | DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723) |
0.4 | 8.8 | GO:1904355 | positive regulation of telomere capping(GO:1904355) |
1.7 | 8.7 | GO:0070327 | thyroid hormone transport(GO:0070327) |
0.2 | 8.7 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
2.6 | 7.9 | GO:0021557 | oculomotor nerve development(GO:0021557) |
0.2 | 7.7 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 217 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 27.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
0.0 | 23.3 | GO:0005615 | extracellular space(GO:0005615) |
1.3 | 19.7 | GO:0042555 | MCM complex(GO:0042555) |
4.4 | 13.2 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
1.1 | 12.4 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
1.5 | 11.9 | GO:0005833 | hemoglobin complex(GO:0005833) |
0.2 | 11.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.1 | 10.9 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
0.1 | 9.6 | GO:0005902 | microvillus(GO:0005902) |
0.0 | 9.3 | GO:0016607 | nuclear speck(GO:0016607) |
1.8 | 9.1 | GO:0097149 | centralspindlin complex(GO:0097149) |
0.1 | 7.9 | GO:0005871 | kinesin complex(GO:0005871) |
0.2 | 7.8 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.2 | 6.7 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.1 | 6.5 | GO:0005681 | spliceosomal complex(GO:0005681) |
0.1 | 6.4 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
1.1 | 6.3 | GO:0001674 | female germ cell nucleus(GO:0001674) |
1.0 | 6.3 | GO:0031262 | Ndc80 complex(GO:0031262) |
0.1 | 6.3 | GO:0030118 | clathrin coat(GO:0030118) |
0.1 | 5.7 | GO:0000776 | kinetochore(GO:0000776) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 329 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 33.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
1.1 | 29.3 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.5 | 20.8 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
0.5 | 19.5 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
0.5 | 16.3 | GO:0017025 | TBP-class protein binding(GO:0017025) |
0.1 | 15.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
2.8 | 14.2 | GO:0005344 | oxygen transporter activity(GO:0005344) |
4.4 | 13.2 | GO:0019912 | cyclin-dependent protein kinase activating kinase activity(GO:0019912) |
3.6 | 10.9 | GO:0000402 | open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402) |
0.4 | 10.0 | GO:0050431 | transforming growth factor beta binding(GO:0050431) |
0.1 | 9.7 | GO:0008186 | RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186) |
1.3 | 9.3 | GO:0070915 | lysophosphatidic acid receptor activity(GO:0070915) |
0.5 | 9.0 | GO:0045295 | gamma-catenin binding(GO:0045295) |
0.5 | 8.5 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
0.5 | 8.1 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.8 | 7.8 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
1.5 | 7.7 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
0.3 | 7.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.3 | 7.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.3 | 6.8 | GO:0017049 | GTP-Rho binding(GO:0017049) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 67 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 45.7 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
0.6 | 25.9 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.4 | 18.3 | PID_ATR_PATHWAY | ATR signaling pathway |
0.3 | 15.1 | PID_DELTA_NP63_PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
1.5 | 13.2 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
0.4 | 11.0 | PID_TOLL_ENDOGENOUS_PATHWAY | Endogenous TLR signaling |
0.7 | 10.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
0.2 | 10.1 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.2 | 10.0 | PID_RET_PATHWAY | Signaling events regulated by Ret tyrosine kinase |
0.2 | 9.7 | PID_AURORA_B_PATHWAY | Aurora B signaling |
0.2 | 9.7 | PID_AP1_PATHWAY | AP-1 transcription factor network |
0.2 | 8.2 | PID_PLK1_PATHWAY | PLK1 signaling events |
0.3 | 7.9 | NABA_PROTEOGLYCANS | Genes encoding proteoglycans |
0.3 | 6.1 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.1 | 5.8 | PID_SMAD2_3NUCLEAR_PATHWAY | Regulation of nuclear SMAD2/3 signaling |
0.0 | 5.1 | NABA_ECM_REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
0.1 | 4.9 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
0.1 | 4.7 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
0.1 | 4.6 | PID_HIF2PATHWAY | HIF-2-alpha transcription factor network |
0.1 | 4.4 | NABA_COLLAGENS | Genes encoding collagen proteins |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 117 entries
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 36.4 | REACTOME_G1_PHASE | Genes involved in G1 Phase |
0.3 | 28.4 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
1.3 | 20.1 | REACTOME_UNWINDING_OF_DNA | Genes involved in Unwinding of DNA |
0.6 | 19.4 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
0.8 | 12.4 | REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
0.3 | 11.3 | REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
0.2 | 10.9 | REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT | Genes involved in Mitochondrial Protein Import |
0.6 | 10.4 | REACTOME_G0_AND_EARLY_G1 | Genes involved in G0 and Early G1 |
0.2 | 10.3 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
1.1 | 9.9 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
0.1 | 9.4 | REACTOME_G_ALPHA_I_SIGNALLING_EVENTS | Genes involved in G alpha (i) signalling events |
0.1 | 9.3 | REACTOME_RESPIRATORY_ELECTRON_TRANSPORT | Genes involved in Respiratory electron transport |
0.1 | 8.9 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
0.5 | 8.1 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.2 | 7.8 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
0.5 | 7.7 | REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY | Genes involved in Notch-HLH transcription pathway |
0.1 | 7.5 | REACTOME_MRNA_SPLICING | Genes involved in mRNA Splicing |
0.5 | 6.9 | REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
0.1 | 6.7 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
0.1 | 6.6 | REACTOME_NCAM1_INTERACTIONS | Genes involved in NCAM1 interactions |