Motif ID: Nfatc2

Z-value: 1.631


Transcription factors associated with Nfatc2:

Gene SymbolEntrez IDGene Name
Nfatc2 ENSMUSG00000027544.10 Nfatc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Nfatc2mm10_v2_chr2_-_168590315_1685903720.077.8e-01Click!


Activity profile for motif Nfatc2.

activity profile for motif Nfatc2


Sorted Z-values histogram for motif Nfatc2

Sorted Z-values for motif Nfatc2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nfatc2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_5796924 6.238 ENSMUST00000174808.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chrX_-_61185558 5.175 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr19_-_5797410 4.182 ENSMUST00000173314.1
 Malat1
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
chr9_+_37367354 3.357 ENSMUST00000051839.7
 Hepacam
hepatocyte cell adhesion molecule
chr14_+_75955003 3.258 ENSMUST00000050120.2
 Kctd4
potassium channel tetramerisation domain containing 4
chr16_+_45093611 3.121 ENSMUST00000099498.2
 Ccdc80
coiled-coil domain containing 80
chr10_-_116972609 3.086 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chr3_-_80802789 2.781 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr12_+_29528382 2.721 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr16_+_43503607 2.479 ENSMUST00000126100.1
ENSMUST00000123047.1
ENSMUST00000156981.1
 Zbtb20


zinc finger and BTB domain containing 20


chr9_+_3000922 2.471 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr16_+_43508118 2.440 ENSMUST00000114690.1
 Zbtb20
zinc finger and BTB domain containing 20
chr7_+_49246812 2.306 ENSMUST00000184945.1
 Nav2
neuron navigator 2
chr9_+_3027439 2.304 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr5_-_123140135 2.214 ENSMUST00000160099.1
 AI480526
expressed sequence AI480526
chr9_+_3037111 2.184 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr15_-_79164477 2.175 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr9_+_3023547 2.153 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr5_-_123141067 2.151 ENSMUST00000162697.1
ENSMUST00000160321.1
ENSMUST00000159637.1
 AI480526


expressed sequence AI480526


chr9_+_3013140 2.148 ENSMUST00000143083.2
 Gm10721
predicted gene 10721

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 311 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 10.4 GO:0035063 nuclear speck organization(GO:0035063)
0.2 6.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.2 5.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 3.6 GO:0007416 synapse assembly(GO:0007416)
0.2 3.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 3.1 GO:0021860 pyramidal neuron development(GO:0021860)
0.3 2.8 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.1 2.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.1 2.6 GO:0032060 bleb assembly(GO:0032060)
0.8 2.5 GO:0007521 muscle cell fate determination(GO:0007521)
0.6 2.3 GO:0021564 glossopharyngeal nerve development(GO:0021563) vagus nerve development(GO:0021564)
0.3 2.3 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.4 2.2 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.4 2.1 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.4 2.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.1 2.1 GO:0061512 protein localization to cilium(GO:0061512)
0.2 2.0 GO:0042118 endothelial cell activation(GO:0042118)
0.2 2.0 GO:0036159 inner dynein arm assembly(GO:0036159)
0.1 2.0 GO:0015701 bicarbonate transport(GO:0015701)
0.5 1.9 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 7.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 7.2 GO:0016607 nuclear speck(GO:0016607)
0.4 6.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.8 GO:0014704 intercalated disc(GO:0014704)
0.0 3.6 GO:0005923 bicellular tight junction(GO:0005923)
0.1 3.5 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.1 GO:0016324 apical plasma membrane(GO:0016324)
0.3 2.9 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 2.8 GO:0032279 asymmetric synapse(GO:0032279)
0.1 2.8 GO:0043194 axon initial segment(GO:0043194)
0.0 2.8 GO:0043197 dendritic spine(GO:0043197)
0.1 2.3 GO:0005605 basal lamina(GO:0005605)
0.1 2.3 GO:0071565 nBAF complex(GO:0071565)
0.1 2.3 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 2.2 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 2.1 GO:0043218 compact myelin(GO:0043218)
0.1 2.1 GO:0032809 neuronal cell body membrane(GO:0032809)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 183 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.1 GO:0008017 microtubule binding(GO:0008017)
0.2 4.0 GO:0001968 fibronectin binding(GO:0001968)
0.1 3.1 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 2.9 GO:0003713 transcription coactivator activity(GO:0003713)
0.5 2.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.2 2.7 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 2.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 2.7 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.4 GO:0051010 microtubule plus-end binding(GO:0051010)
0.5 2.1 GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038)
0.1 2.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 2.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 2.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.5 1.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 1.9 GO:0070699 type II activin receptor binding(GO:0070699)
0.1 1.9 GO:0038191 neuropilin binding(GO:0038191)
0.2 1.8 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 1.8 GO:0035198 miRNA binding(GO:0035198)
0.1 1.8 GO:0043422 protein kinase B binding(GO:0043422)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.1 2.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.1 2.7 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 2.7 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.5 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 2.3 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.1 2.0 PID_A6B1_A6B4_INTEGRIN_PATHWAY a6b1 and a6b4 Integrin signaling
0.1 2.0 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.0 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.2 1.9 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.6 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.0 1.5 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.5 PID_P75_NTR_PATHWAY p75(NTR)-mediated signaling
0.1 1.2 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 1.2 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.2 PID_ECADHERIN_STABILIZATION_PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.1 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.1 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.0 PID_ATM_PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.9 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 3.7 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 2.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.1 2.7 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 2.6 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.0 2.3 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.2 2.1 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 2.0 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.8 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 1.8 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.1 1.6 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.6 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 1.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.5 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 1.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.4 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
0.1 1.2 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.1 1.2 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events