Motif ID: Zbtb7b

Z-value: 1.029


Transcription factors associated with Zbtb7b:

Gene SymbolEntrez IDGene Name
Zbtb7b ENSMUSG00000028042.9 Zbtb7b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb7bmm10_v2_chr3_-_89393294_893933780.068.2e-01Click!


Activity profile for motif Zbtb7b.

activity profile for motif Zbtb7b


Sorted Z-values histogram for motif Zbtb7b

Sorted Z-values for motif Zbtb7b



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb7b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 3.114 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr14_-_70642268 2.850 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr2_-_117342949 2.475 ENSMUST00000102534.4
 Rasgrp1
RAS guanyl releasing protein 1
chr2_-_117342831 2.207 ENSMUST00000178884.1
 Rasgrp1
RAS guanyl releasing protein 1
chr8_-_87959560 2.206 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr11_+_120948480 2.172 ENSMUST00000070653.6
 Slc16a3
solute carrier family 16 (monocarboxylic acid transporters), member 3
chr17_+_34592248 2.052 ENSMUST00000038149.6
 Pbx2
pre B cell leukemia homeobox 2
chr2_-_117342709 2.038 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr7_-_4752972 1.824 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr5_+_137350371 1.811 ENSMUST00000166239.1
ENSMUST00000111054.1
 Ephb4

Eph receptor B4

chr17_-_23684019 1.807 ENSMUST00000085989.5
 Cldn9
claudin 9
chr9_-_91365778 1.796 ENSMUST00000065360.3
 Zic1
zinc finger protein of the cerebellum 1
chr10_+_84756055 1.718 ENSMUST00000060397.6
 Rfx4
regulatory factor X, 4 (influences HLA class II expression)
chr7_+_51879041 1.545 ENSMUST00000107591.2
 Gas2
growth arrest specific 2
chr7_+_51878967 1.535 ENSMUST00000051912.6
 Gas2
growth arrest specific 2
chr8_-_105471481 1.445 ENSMUST00000014990.6
 Tppp3
tubulin polymerization-promoting protein family member 3
chr17_-_26099257 1.393 ENSMUST00000053575.3
 Gm8186
predicted gene 8186
chr3_+_34649987 1.272 ENSMUST00000099151.2
 Sox2
SRY-box containing gene 2
chr7_-_126799163 1.220 ENSMUST00000032934.5
 Aldoa
aldolase A, fructose-bisphosphate
chr11_+_88068242 1.175 ENSMUST00000018521.4
 Vezf1
vascular endothelial zinc finger 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 87 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 6.7 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.4 3.1 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.0 3.1 GO:0008360 regulation of cell shape(GO:0008360)
0.0 2.8 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.2 2.4 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 2.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 2.1 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 2.0 GO:0051451 myoblast migration(GO:0051451)
0.1 2.0 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.5 1.9 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.5 1.8 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.0 1.8 GO:0007628 adult walking behavior(GO:0007628)
0.3 1.7 GO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.2 1.7 GO:0001714 endodermal cell fate specification(GO:0001714)
0.3 1.5 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.5 1.4 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.5 1.4 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.1 1.4 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 1.4 GO:0009299 mRNA transcription(GO:0009299)
0.0 1.4 GO:0046785 microtubule polymerization(GO:0046785)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.4 GO:0005667 transcription factor complex(GO:0005667)
0.2 2.4 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 2.0 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.4 1.9 GO:0035189 Rb-E2F complex(GO:0035189)
0.1 1.8 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.8 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.5 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 1.5 GO:0005871 kinesin complex(GO:0005871)
0.2 1.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2 1.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 1.1 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 0.9 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.9 GO:0043203 axon hillock(GO:0043203)
0.1 0.8 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.7 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0 0.7 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.7 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.7 GO:0051233 spindle midzone(GO:0051233)
0.1 0.5 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0 7.1 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.6 6.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.9 2.8 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 2.8 GO:0001618 virus receptor activity(GO:0001618)
0.4 2.4 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 2.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 2.1 GO:0001047 core promoter binding(GO:0001047)
0.1 1.8 GO:0005003 ephrin receptor activity(GO:0005003)
0.1 1.5 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 1.5 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.4 GO:0070411 I-SMAD binding(GO:0070411)
0.1 1.4 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.3 GO:0035198 miRNA binding(GO:0035198)
0.0 1.2 GO:0008276 protein methyltransferase activity(GO:0008276)
0.1 1.1 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol trisphosphate phosphatase activity(GO:0046030)
0.0 1.1 GO:0001222 transcription corepressor binding(GO:0001222)
0.2 1.0 GO:1904047 S-adenosyl-L-methionine binding(GO:1904047)
0.3 0.9 GO:0030172 troponin C binding(GO:0030172)
0.0 0.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.7 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 3.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 2.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 2.8 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 1.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.9 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.1 1.8 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.1 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 1.1 PID_AP1_PATHWAY AP-1 transcription factor network
0.0 1.1 PID_E2F_PATHWAY E2F transcription factor network
0.1 0.7 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.6 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.3 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.8 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.1 3.1 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.4 2.8 REACTOME_FGFR4_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 2.8 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.2 2.7 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 2.4 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.2 2.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 1.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.4 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.1 REACTOME_IL_RECEPTOR_SHC_SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.9 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction
0.1 0.7 REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.7 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.6 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.5 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.4 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME_METABOLISM_OF_POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.4 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling