Motif ID: Hand1
Z-value: 1.002
Transcription factors associated with Hand1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hand1 | ENSMUSG00000037335.7 | Hand1 |
Top targets:
Showing 1 to 20 of 200 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 135 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 4.4 | GO:0035063 | nuclear speck organization(GO:0035063) |
| 0.8 | 3.1 | GO:0042138 | meiotic DNA double-strand break formation(GO:0042138) |
| 0.0 | 3.0 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.1 | 2.8 | GO:0010765 | positive regulation of sodium ion transport(GO:0010765) |
| 0.5 | 2.7 | GO:1905169 | protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171) |
| 0.1 | 2.4 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 2.4 | GO:0045838 | positive regulation of membrane potential(GO:0045838) |
| 0.0 | 2.4 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.4 | 2.2 | GO:0046880 | regulation of follicle-stimulating hormone secretion(GO:0046880) follicle-stimulating hormone secretion(GO:0046884) |
| 0.0 | 2.2 | GO:0002028 | regulation of sodium ion transport(GO:0002028) |
| 0.3 | 2.1 | GO:2001023 | regulation of response to drug(GO:2001023) |
| 0.3 | 2.1 | GO:0097118 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) |
| 0.2 | 2.1 | GO:2000253 | positive regulation of feeding behavior(GO:2000253) |
| 0.7 | 2.0 | GO:0071873 | response to norepinephrine(GO:0071873) |
| 0.2 | 2.0 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.4 | 1.8 | GO:0098735 | cellular response to caffeine(GO:0071313) positive regulation of the force of heart contraction(GO:0098735) |
| 0.3 | 1.7 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
| 0.1 | 1.6 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.5 | 1.5 | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790) |
| 0.0 | 1.5 | GO:0007613 | memory(GO:0007613) |
Gene overrepresentation in cellular_component category:
Showing 1 to 20 of 57 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.5 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.0 | 3.4 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.4 | 2.7 | GO:0044308 | axonal spine(GO:0044308) |
| 0.7 | 2.2 | GO:0043512 | inhibin-betaglycan-ActRII complex(GO:0034673) inhibin A complex(GO:0043512) |
| 0.2 | 2.1 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.1 | 2.1 | GO:1990635 | proximal dendrite(GO:1990635) |
| 0.0 | 2.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 2.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 2.0 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 2.0 | GO:0030122 | AP-2 adaptor complex(GO:0030122) |
| 0.1 | 2.0 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 1.9 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 1.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.8 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.4 | 1.7 | GO:0099569 | presynaptic cytoskeleton(GO:0099569) |
| 0.1 | 1.6 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.0 | 1.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.5 | GO:0005814 | centriole(GO:0005814) |
| 0.3 | 1.4 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 1.4 | GO:0030175 | filopodium(GO:0030175) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 100 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.8 | 3.1 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.0 | 2.9 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 2.7 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 2.6 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.4 | 2.4 | GO:1904315 | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.3 | 2.2 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.0 | 2.2 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.4 | 2.1 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.0 | 2.1 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.5 | 2.0 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.4 | 2.0 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.1 | 2.0 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 2.0 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.4 | 1.8 | GO:0086038 | calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential(GO:0086038) |
| 0.1 | 1.5 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 0.0 | 1.5 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 1.5 | GO:1990782 | protein tyrosine kinase binding(GO:1990782) |
| 0.1 | 1.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.1 | 1.3 | GO:0031005 | filamin binding(GO:0031005) |
Gene overrepresentation in C2:CP category:
Showing 1 to 20 of 28 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.0 | PID_EPHB_FWD_PATHWAY | EPHB forward signaling |
| 0.1 | 1.5 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 1.5 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.5 | PID_NOTCH_PATHWAY | Notch signaling pathway |
| 0.0 | 1.4 | PID_IL12_STAT4_PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 1.3 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.1 | 1.2 | PID_RHODOPSIN_PATHWAY | Visual signal transduction: Rods |
| 0.0 | 1.2 | PID_FOXO_PATHWAY | FoxO family signaling |
| 0.0 | 1.1 | PID_WNT_CANONICAL_PATHWAY | Canonical Wnt signaling pathway |
| 0.0 | 1.0 | PID_PTP1B_PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 0.9 | PID_S1P_S1P1_PATHWAY | S1P1 pathway |
| 0.0 | 0.9 | PID_HDAC_CLASSIII_PATHWAY | Signaling events mediated by HDAC Class III |
| 0.0 | 0.9 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.8 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 0.8 | PID_FAK_PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 0.7 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.7 | PID_ECADHERIN_STABILIZATION_PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 0.7 | PID_P53_REGULATION_PATHWAY | p53 pathway |
| 0.0 | 0.6 | PID_TRKR_PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 0.5 | NABA_BASEMENT_MEMBRANES | Genes encoding structural components of basement membranes |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 20 of 44 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.0 | REACTOME_GABA_A_RECEPTOR_ACTIVATION | Genes involved in GABA A receptor activation |
| 0.0 | 2.8 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 2.4 | REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.5 | 2.2 | REACTOME_GLYCOPROTEIN_HORMONES | Genes involved in Glycoprotein hormones |
| 0.1 | 2.1 | REACTOME_NEPHRIN_INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 1.9 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.1 | 1.8 | REACTOME_PLATELET_CALCIUM_HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.2 | 1.4 | REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.0 | 1.4 | REACTOME_TIGHT_JUNCTION_INTERACTIONS | Genes involved in Tight junction interactions |
| 0.0 | 1.4 | REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 1.4 | REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.0 | 1.2 | REACTOME_G_ALPHA_S_SIGNALLING_EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 1.1 | REACTOME_ACTIVATION_OF_RAC | Genes involved in Activation of Rac |
| 0.1 | 1.0 | REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 1.0 | REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.0 | 0.9 | REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 0.7 | REACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.0 | 0.7 | REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.0 | 0.7 | REACTOME_INSULIN_RECEPTOR_RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 0.6 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
