Motif ID: Irf2_Irf1_Irf8_Irf9_Irf7

Z-value: 5.008

Transcription factors associated with Irf2_Irf1_Irf8_Irf9_Irf7:

Gene SymbolEntrez IDGene Name
Irf1 ENSMUSG00000018899.10 Irf1
Irf2 ENSMUSG00000031627.7 Irf2
Irf7 ENSMUSG00000025498.8 Irf7
Irf8 ENSMUSG00000041515.3 Irf8
Irf9 ENSMUSG00000002325.8 Irf9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Irf1mm10_v2_chr11_+_53770458_537705090.551.9e-02Click!
Irf7mm10_v2_chr7_-_141266415_141266481-0.292.4e-01Click!
Irf9mm10_v2_chr14_+_55604550_55604579-0.214.0e-01Click!
Irf8mm10_v2_chr8_+_120736352_1207363850.204.2e-01Click!
Irf2mm10_v2_chr8_+_46739745_46739791-0.048.6e-01Click!


Activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7.

activity profile for motif Irf2_Irf1_Irf8_Irf9_Irf7


Sorted Z-values histogram for motif Irf2_Irf1_Irf8_Irf9_Irf7

Sorted Z-values for motif Irf2_Irf1_Irf8_Irf9_Irf7



Network of associatons between targets according to the STRING database.



First level regulatory network of Irf2_Irf1_Irf8_Irf9_Irf7

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3013140 44.435 ENSMUST00000143083.2
 Gm10721
predicted gene 10721
chr9_+_3034599 44.163 ENSMUST00000178641.1
 Gm17535
predicted gene, 17535
chr9_+_3027439 41.736 ENSMUST00000177875.1
ENSMUST00000179982.1
 Gm10717

predicted gene 10717

chr9_+_3023547 40.677 ENSMUST00000099046.3
 Gm10718
predicted gene 10718
chr9_+_3004457 40.432 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr9_+_3015654 38.753 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3037111 37.382 ENSMUST00000177969.1
 Gm10715
predicted gene 10715
chr9_+_3017408 37.086 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr14_-_19418930 36.422 ENSMUST00000177817.1
 Gm21738
predicted gene, 21738
chr9_+_3000922 36.338 ENSMUST00000151376.2
 Gm10722
predicted gene 10722
chr2_-_98667264 36.092 ENSMUST00000099683.1
 Gm10800
predicted gene 10800
chr9_+_3036877 35.854 ENSMUST00000155807.2
 Gm10715
predicted gene 10715
chr9_+_3005125 34.076 ENSMUST00000179881.1
 Gm11168
predicted gene 11168
chr9_+_3018753 33.694 ENSMUST00000179272.1
 Gm10719
predicted gene 10719
chr9_+_3025417 32.269 ENSMUST00000075573.6
 Gm10717
predicted gene 10717
chr2_+_98662227 17.876 ENSMUST00000099684.3
 Gm10801
predicted gene 10801
chr2_-_105399286 14.937 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chrX_-_134161928 13.888 ENSMUST00000033611.4
 Xkrx
X Kell blood group precursor related X linked
chr2_+_122147680 10.535 ENSMUST00000102476.4
 B2m
beta-2 microglobulin
chr19_+_36409719 9.977 ENSMUST00000062389.5
 Pcgf5
polycomb group ring finger 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 316 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.1 12.6 GO:0002481 antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481)
2.0 12.2 GO:0060330 regulation of response to interferon-gamma(GO:0060330)
2.5 10.1 GO:0060332 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
1.0 8.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.4 8.1 GO:0042832 defense response to protozoan(GO:0042832)
1.3 8.0 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
1.1 7.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 7.6 GO:0010390 histone monoubiquitination(GO:0010390)
0.3 7.0 GO:0044458 motile cilium assembly(GO:0044458)
0.4 6.7 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.8 6.5 GO:0048625 myoblast fate commitment(GO:0048625)
0.2 6.5 GO:0071346 cellular response to interferon-gamma(GO:0071346)
2.1 6.2 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
1.2 5.9 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.7 5.9 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.4 5.7 GO:1902990 leading strand elongation(GO:0006272) mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.6 5.3 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.2 5.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
1.0 5.2 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.2 5.0 GO:0097150 neuronal stem cell population maintenance(GO:0097150)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 138 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 223.1 GO:0005575 cellular_component(GO:0005575)
1.5 18.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 10.8 GO:0031519 PcG protein complex(GO:0031519)
0.8 10.6 GO:0020003 symbiont-containing vacuole(GO:0020003)
0.1 8.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.5 7.4 GO:0044754 secondary lysosome(GO:0005767) autolysosome(GO:0044754)
0.1 7.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 7.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 6.7 GO:0036126 sperm flagellum(GO:0036126)
0.7 6.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 6.0 GO:0000785 chromatin(GO:0000785)
1.0 5.9 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 5.8 GO:0005604 basement membrane(GO:0005604)
1.9 5.7 GO:0070557 PCNA-p21 complex(GO:0070557)
0.6 5.2 GO:0030478 actin cap(GO:0030478)
0.1 5.0 GO:0016605 PML body(GO:0016605)
0.3 4.8 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.6 4.7 GO:0033269 internode region of axon(GO:0033269)
0.4 4.6 GO:0005677 chromatin silencing complex(GO:0005677)
0.3 4.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 200 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.0 GO:0003924 GTPase activity(GO:0003924)
0.1 16.1 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.7 10.9 GO:0046977 TAP binding(GO:0046977)
0.4 10.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 9.9 GO:0031491 nucleosome binding(GO:0031491)
0.0 8.8 GO:0003682 chromatin binding(GO:0003682)
0.0 8.3 GO:0042393 histone binding(GO:0042393)
0.0 8.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 7.6 GO:0004386 helicase activity(GO:0004386)
1.3 6.7 GO:0032027 myosin light chain binding(GO:0032027)
0.0 6.7 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.3 6.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.5 6.4 GO:0031386 protein tag(GO:0031386)
2.0 6.1 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
0.4 6.1 GO:0017166 vinculin binding(GO:0017166)
0.1 6.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.5 5.9 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 5.9 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
1.3 5.2 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.3 5.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 33.0 PID_IL12_2PATHWAY IL12-mediated signaling events
0.3 12.0 PID_BARD1_PATHWAY BARD1 signaling events
0.2 11.5 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.1 11.2 PID_AP1_PATHWAY AP-1 transcription factor network
0.1 8.1 PID_PLK1_PATHWAY PLK1 signaling events
0.2 7.4 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 6.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.2 5.0 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 5.0 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.2 4.9 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.1 4.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.3 3.4 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.4 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.1 3.1 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.0 3.1 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.0 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.8 PID_BMP_PATHWAY BMP receptor signaling
0.0 2.8 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.1 2.6 PID_E2F_PATHWAY E2F transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.0 13.1 REACTOME_POL_SWITCHING Genes involved in Polymerase switching
3.2 9.7 REACTOME_ENDOSOMAL_VACUOLAR_PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.3 8.6 REACTOME_NEGATIVE_REGULATORS_OF_RIG_I_MDA5_SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.6 8.2 REACTOME_REGULATION_OF_IFNA_SIGNALING Genes involved in Regulation of IFNA signaling
0.3 8.2 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.5 8.0 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.4 7.7 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 6.7 REACTOME_AMYLOIDS Genes involved in Amyloids
0.2 6.1 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2 5.8 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.1 5.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 5.3 REACTOME_MUSCLE_CONTRACTION Genes involved in Muscle contraction
0.2 5.2 REACTOME_CYTOSOLIC_TRNA_AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.2 4.9 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 4.9 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 4.4 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.2 4.3 REACTOME_INHIBITION_OF_THE_PROTEOLYTIC_ACTIVITY_OF_APC_C_REQUIRED_FOR_THE_ONSET_OF_ANAPHASE_BY_MITOTIC_SPINDLE_CHECKPOINT_COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 3.8 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 3.6 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI