Motif ID: Tfap2c

Z-value: 0.668


Transcription factors associated with Tfap2c:

Gene SymbolEntrez IDGene Name
Tfap2c ENSMUSG00000028640.5 Tfap2c

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2cmm10_v2_chr2_+_172550761_172550782-0.691.7e-03Click!


Activity profile for motif Tfap2c.

activity profile for motif Tfap2c


Sorted Z-values histogram for motif Tfap2c

Sorted Z-values for motif Tfap2c



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2c

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_119138415 2.395 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr8_+_70493156 2.015 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr2_+_76406529 1.601 ENSMUST00000111929.1
ENSMUST00000077972.4
ENSMUST00000111930.2
 Osbpl6


oxysterol binding protein-like 6


chr10_+_13966268 1.483 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr11_+_67455339 1.444 ENSMUST00000108681.1
 Gas7
growth arrest specific 7
chr9_+_89909775 1.439 ENSMUST00000034912.4
ENSMUST00000034909.4
 Rasgrf1

RAS protein-specific guanine nucleotide-releasing factor 1

chr5_-_131307848 1.368 ENSMUST00000086023.5
 Wbscr17
Williams-Beuren syndrome chromosome region 17 homolog (human)
chr4_+_152338887 1.341 ENSMUST00000005175.4
 Chd5
chromodomain helicase DNA binding protein 5
chr5_-_71095765 1.292 ENSMUST00000000572.5
 Gabra2
gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2
chr4_+_152338619 1.255 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr9_-_29412204 1.246 ENSMUST00000115237.1
 Ntm
neurotrimin
chr15_+_100761741 1.209 ENSMUST00000023776.6
 Slc4a8
solute carrier family 4 (anion exchanger), member 8
chr2_+_91945703 1.167 ENSMUST00000178895.1
 Gm9821
predicted gene 9821
chr9_-_29411736 1.162 ENSMUST00000115236.1
 Ntm
neurotrimin
chr18_-_61911783 1.137 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr9_+_45430293 1.096 ENSMUST00000034592.8
 Dscaml1
Down syndrome cell adhesion molecule like 1
chr4_-_22488296 1.065 ENSMUST00000178174.1
 Pou3f2
POU domain, class 3, transcription factor 2
chr7_+_99535652 1.050 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr16_+_35154870 1.024 ENSMUST00000114913.1
 Adcy5
adenylate cyclase 5
chr4_+_104367549 1.014 ENSMUST00000106830.2
 Dab1
disabled 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.6 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.4 2.4 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.3 2.0 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.1 1.8 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 1.3 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.2 GO:0051453 regulation of intracellular pH(GO:0051453)
0.1 1.1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 1.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 1.1 GO:0036465 synaptic vesicle recycling(GO:0036465)
0.0 1.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.3 1.0 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812) lateral motor column neuron migration(GO:0097477)
0.2 1.0 GO:0051012 microtubule sliding(GO:0051012)
0.2 1.0 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393) follicle-stimulating hormone signaling pathway(GO:0042699)
0.2 1.0 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 1.0 GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195)
0.1 1.0 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.0 1.0 GO:0003382 epithelial cell morphogenesis(GO:0003382)
0.2 0.9 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.2 0.9 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.9 GO:0032482 Rab protein signal transduction(GO:0032482)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.9 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.7 2.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.1 1.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 1.5 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 1.5 GO:0005884 actin filament(GO:0005884)
0.1 1.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 1.4 GO:0005903 brush border(GO:0005903)
0.1 1.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 1.0 GO:0061689 tricellular tight junction(GO:0061689)
0.1 1.0 GO:0031143 pseudopodium(GO:0031143)
0.1 1.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.0 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.9 GO:0005638 lamin filament(GO:0005638)
0.0 0.9 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.8 GO:0043196 varicosity(GO:0043196)
0.0 0.8 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.2 0.7 GO:0098855 HCN channel complex(GO:0098855)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.6 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.6 2.4 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.3 2.0 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 1.9 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.2 1.3 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.1 1.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 1.0 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.2 1.0 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1 1.0 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.0 1.0 GO:0042169 SH2 domain binding(GO:0042169)
0.2 0.9 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 0.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.8 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.0 0.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.2 0.7 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.2 0.7 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.1 0.7 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 0.7 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.6 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)

Gene overrepresentation in C2:CP category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.7 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.1 1.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 1.6 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 1.2 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.9 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.4 PID_P38_GAMMA_DELTA_PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.4 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.2 PID_KIT_PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.4 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.7 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.3 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 1.3 REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 1.3 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.0 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 0.9 REACTOME_DAG_AND_IP3_SIGNALING Genes involved in DAG and IP3 signaling
0.0 0.9 REACTOME_APOPTOTIC_CLEAVAGE_OF_CELLULAR_PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 0.8 REACTOME_SIGNALING_BY_ACTIVATED_POINT_MUTANTS_OF_FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 0.8 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.7 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.7 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.5 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 0.4 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 0.4 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.3 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis