Motif ID: Hivep1

Z-value: 0.798


Transcription factors associated with Hivep1:

Gene SymbolEntrez IDGene Name
Hivep1 ENSMUSG00000021366.7 Hivep1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Hivep1mm10_v2_chr13_+_42052015_420520720.581.2e-02Click!


Activity profile for motif Hivep1.

activity profile for motif Hivep1


Sorted Z-values histogram for motif Hivep1

Sorted Z-values for motif Hivep1



Network of associatons between targets according to the STRING database.



First level regulatory network of Hivep1

PNG image of the network

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Top targets:


Showing 1 to 20 of 141 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_79164477 5.462 ENSMUST00000040019.4
 Sox10
SRY-box containing gene 10
chr17_-_83631892 3.266 ENSMUST00000051482.1
 Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr3_-_88000350 3.027 ENSMUST00000090971.5
 Bcan
brevican
chr14_+_80000292 2.805 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr10_-_27616895 2.647 ENSMUST00000092639.5
 Lama2
laminin, alpha 2
chr6_-_136171722 2.376 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr2_-_113758638 2.097 ENSMUST00000099575.3
 Grem1
gremlin 1
chr3_+_117575268 2.095 ENSMUST00000039564.6
 4833424O15Rik
RIKEN cDNA 4833424O15 gene
chr7_+_99535652 1.879 ENSMUST00000032995.8
ENSMUST00000162404.1
 Arrb1

arrestin, beta 1

chr3_+_7612702 1.859 ENSMUST00000181286.1
 Gm16685
predicted gene, 16685
chr2_-_104257400 1.837 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr1_-_36273425 1.659 ENSMUST00000056946.6
 Neurl3
neuralized homolog 3 homolog (Drosophila)
chr7_+_99535439 1.652 ENSMUST00000098266.2
ENSMUST00000179755.1
 Arrb1

arrestin, beta 1

chr7_-_4546567 1.645 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr16_+_38089001 1.552 ENSMUST00000023507.6
 Gsk3b
glycogen synthase kinase 3 beta
chr5_+_90759299 1.524 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr3_-_53657339 1.407 ENSMUST00000091137.4
 Frem2
Fras1 related extracellular matrix protein 2
chr11_+_78188737 1.364 ENSMUST00000108322.2
 Rab34
RAB34, member of RAS oncogene family
chr2_-_5063996 1.348 ENSMUST00000114996.1
 Optn
optineurin
chr18_+_37496997 1.308 ENSMUST00000059571.5
 Pcdhb19
protocadherin beta 19

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 5.5 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.6 3.5 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.0 3.0 GO:0021766 hippocampus development(GO:0021766)
0.1 2.8 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.5 2.6 GO:0032224 positive regulation of synaptic transmission, cholinergic(GO:0032224)
0.6 2.4 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.6 2.4 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.0 2.3 GO:0007416 synapse assembly(GO:0007416)
0.7 2.1 GO:1901228 regulation of osteoclast proliferation(GO:0090289) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) negative regulation of bone development(GO:1903011)
0.3 2.1 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.4 2.0 GO:1905169 protein localization to phagocytic vesicle(GO:1905161) regulation of protein localization to phagocytic vesicle(GO:1905169) positive regulation of protein localization to phagocytic vesicle(GO:1905171)
0.1 1.8 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.5 1.6 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0 1.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.5 1.5 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.1 1.4 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
0.3 1.2 GO:0007066 female meiosis sister chromatid cohesion(GO:0007066)
0.1 1.2 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 1.1 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.0 1.1 GO:0031532 actin cytoskeleton reorganization(GO:0031532)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.5 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 3.5 GO:0031143 pseudopodium(GO:0031143)
0.2 2.8 GO:0042581 specific granule(GO:0042581)
0.2 2.4 GO:0043083 synaptic cleft(GO:0043083)
0.0 2.1 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 2.1 GO:0030667 secretory granule membrane(GO:0030667)
0.1 1.7 GO:0005605 basal lamina(GO:0005605)
0.4 1.6 GO:1990769 proximal neuron projection(GO:1990769)
0.1 1.6 GO:1990909 Wnt signalosome(GO:1990909)
0.0 1.4 GO:0005604 basement membrane(GO:0005604)
0.0 1.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.4 1.2 GO:0000802 transverse filament(GO:0000802)
0.0 1.2 GO:0060170 ciliary membrane(GO:0060170)
0.3 1.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.8 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.7 GO:0001741 XY body(GO:0001741)
0.1 0.6 GO:0033010 paranodal junction(GO:0033010)
0.1 0.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 6.3 GO:1990841 promoter-specific chromatin binding(GO:1990841)
1.2 3.5 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.2 3.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 3.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 2.6 GO:0036122 BMP binding(GO:0036122)
0.3 2.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.3 2.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 2.2 GO:0070412 R-SMAD binding(GO:0070412)
0.1 2.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 1.9 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 1.6 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 1.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.1 1.1 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 1.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.0 GO:0005125 cytokine activity(GO:0005125)
0.3 0.8 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
0.0 0.8 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.7 GO:0032405 MutLalpha complex binding(GO:0032405) MutSalpha complex binding(GO:0032407)
0.0 0.7 GO:0005227 calcium activated cation channel activity(GO:0005227)

Gene overrepresentation in C2:CP category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 PID_BMP_PATHWAY BMP receptor signaling
0.1 3.5 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 3.0 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.3 2.6 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 2.4 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 1.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 1.0 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 0.8 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.8 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.0 0.7 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.7 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.6 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.6 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 0.6 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.5 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.4 PID_IL2_1PATHWAY IL2-mediated signaling events
0.0 0.1 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.1 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 3.2 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 3.0 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 2.9 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.9 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.5 REACTOME_REGULATION_OF_INSULIN_SECRETION Genes involved in Regulation of Insulin Secretion
0.0 1.2 REACTOME_MEIOTIC_SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.1 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME_TRAF6_MEDIATED_NFKB_ACTIVATION Genes involved in TRAF6 mediated NF-kB activation
0.0 0.8 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.8 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 0.7 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.7 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 0.6 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.6 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.6 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING Genes involved in PIP3 activates AKT signaling
0.1 0.5 REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.4 REACTOME_GROWTH_HORMONE_RECEPTOR_SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.2 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation