Motif ID: Creb3

Z-value: 0.837


Transcription factors associated with Creb3:

Gene SymbolEntrez IDGene Name
Creb3 ENSMUSG00000028466.9 Creb3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Creb3mm10_v2_chr4_+_43562672_43562947-0.419.2e-02Click!


Activity profile for motif Creb3.

activity profile for motif Creb3


Sorted Z-values histogram for motif Creb3

Sorted Z-values for motif Creb3



Network of associatons between targets according to the STRING database.



First level regulatory network of Creb3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_120431770 2.664 ENSMUST00000031591.7
 Lhx5
LIM homeobox protein 5
chrX_-_60893430 2.615 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr7_-_45092130 2.489 ENSMUST00000148175.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr7_-_45091713 2.279 ENSMUST00000141576.1
 Rcn3
reticulocalbin 3, EF-hand calcium binding domain
chr5_-_135251209 2.249 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr15_+_79516396 2.166 ENSMUST00000010974.7
 Kdelr3
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
chr4_+_3938888 2.020 ENSMUST00000121110.1
ENSMUST00000108386.1
ENSMUST00000149544.1
 Chchd7


coiled-coil-helix-coiled-coil-helix domain containing 7


chr2_-_105399286 1.910 ENSMUST00000006128.6
 Rcn1
reticulocalbin 1
chr7_-_143460989 1.893 ENSMUST00000167912.1
ENSMUST00000037287.6
 Cdkn1c

cyclin-dependent kinase inhibitor 1C (P57)

chr4_+_47474652 1.875 ENSMUST00000065678.5
ENSMUST00000137461.1
ENSMUST00000125622.1
 Sec61b


Sec61 beta subunit


chr11_-_94653964 1.762 ENSMUST00000039949.4
 Eme1
essential meiotic endonuclease 1 homolog 1 (S. pombe)
chr7_-_144939823 1.617 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr1_+_74791516 1.590 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr7_-_45092198 1.383 ENSMUST00000140449.1
ENSMUST00000117546.1
ENSMUST00000019683.3
 Rcn3


reticulocalbin 3, EF-hand calcium binding domain


chr3_-_36571952 1.328 ENSMUST00000029270.3
 Ccna2
cyclin A2
chr3_+_116878227 1.273 ENSMUST00000040260.6
 Frrs1
ferric-chelate reductase 1
chr2_+_119112793 1.243 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr13_-_23762378 1.215 ENSMUST00000091701.2
 Hist1h3a
histone cluster 1, H3a
chr7_-_25250720 1.204 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr5_-_149053038 1.187 ENSMUST00000085546.6
 Hmgb1
high mobility group box 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.2 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 3.2 GO:0032526 response to retinoic acid(GO:0032526)
0.3 2.7 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.1 2.6 GO:0007530 sex determination(GO:0007530)
0.7 2.2 GO:1990523 bone regeneration(GO:1990523)
0.2 2.2 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 2.2 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.2 2.0 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.2 2.0 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.6 1.9 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.2 1.9 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.4 1.8 GO:0072429 response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.2 1.6 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 1.6 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.5 1.4 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
0.2 1.4 GO:0018158 protein oxidation(GO:0018158)
0.0 1.3 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.4 1.2 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.4 1.2 GO:0045819 plasmacytoid dendritic cell activation(GO:0002270) positive regulation of glycogen catabolic process(GO:0045819)
0.2 1.2 GO:0010668 ectodermal cell differentiation(GO:0010668)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.4 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 2.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.4 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 2.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 2.2 GO:0031527 filopodium membrane(GO:0031527)
0.6 1.9 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.2 1.9 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 1.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 1.8 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.2 1.3 GO:0001940 male pronucleus(GO:0001940)
0.2 1.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 1.2 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.2 GO:0000800 lateral element(GO:0000800)
0.0 1.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.2 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.1 GO:0097413 Lewy body(GO:0097413)
0.0 1.1 GO:0035371 microtubule plus-end(GO:0035371)
0.0 1.1 GO:0005844 polysome(GO:0005844)
0.0 1.0 GO:0032587 ruffle membrane(GO:0032587)
0.2 0.8 GO:0043527 tRNA methyltransferase complex(GO:0043527)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.0 GO:0005509 calcium ion binding(GO:0005509)
0.1 3.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.8 3.2 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 3.2 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.0 2.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 2.3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1 2.3 GO:0005109 frizzled binding(GO:0005109)
0.1 2.2 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 2.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 2.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.5 1.9 GO:0048408 epidermal growth factor binding(GO:0048408)
0.3 1.9 GO:0008312 7S RNA binding(GO:0008312)
0.1 1.9 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 1.8 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 1.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 1.5 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.0 1.4 GO:0008276 protein methyltransferase activity(GO:0008276)
0.3 1.3 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.4 1.2 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.3 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.2 2.9 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 2.2 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.6 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.5 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 1.2 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 1.1 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 1.1 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.9 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.8 PID_S1P_META_PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.6 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 0.6 PID_PLK1_PATHWAY PLK1 signaling events
0.1 0.5 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.5 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.5 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.4 PID_THROMBIN_PAR1_PATHWAY PAR1-mediated thrombin signaling events
0.0 0.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.3 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.0 0.2 PID_FOXO_PATHWAY FoxO family signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.1 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 4.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 2.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.2 REACTOME_ER_PHAGOSOME_PATHWAY Genes involved in ER-Phagosome pathway
0.1 1.9 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.9 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.6 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 1.5 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.3 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1 1.2 REACTOME_ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.0 1.2 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.1 REACTOME_N_GLYCAN_TRIMMING_IN_THE_ER_AND_CALNEXIN_CALRETICULIN_CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 1.1 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.1 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 0.9 REACTOME_PURINE_CATABOLISM Genes involved in Purine catabolism
0.0 0.9 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.8 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 0.7 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 0.7 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases