Motif ID: Prrx1_Isx_Prrxl1

Z-value: 0.612

Transcription factors associated with Prrx1_Isx_Prrxl1:

Gene SymbolEntrez IDGene Name
Isx ENSMUSG00000031621.3 Isx
Prrx1 ENSMUSG00000026586.10 Prrx1
Prrxl1 ENSMUSG00000041730.7 Prrxl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrx1mm10_v2_chr1_-_163313661_1633137100.381.2e-01Click!
Prrxl1mm10_v2_chr14_+_32599922_32599932-0.351.6e-01Click!


Activity profile for motif Prrx1_Isx_Prrxl1.

activity profile for motif Prrx1_Isx_Prrxl1


Sorted Z-values histogram for motif Prrx1_Isx_Prrxl1

Sorted Z-values for motif Prrx1_Isx_Prrxl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prrx1_Isx_Prrxl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_118478344 1.978 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr4_-_110292719 1.539 ENSMUST00000106601.1
 Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr3_+_146121655 1.506 ENSMUST00000039450.4
 Mcoln3
mucolipin 3
chr9_+_118478182 1.396 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr12_+_9029982 1.358 ENSMUST00000085741.1
 Ttc32
tetratricopeptide repeat domain 32
chr12_+_79297345 1.271 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr14_+_73237891 1.247 ENSMUST00000044405.6
 Lpar6
lysophosphatidic acid receptor 6
chr4_-_155645408 1.118 ENSMUST00000115821.2
 Gm10563
predicted gene 10563
chr8_-_106573461 1.076 ENSMUST00000073722.5
 Gm10073
predicted pseudogene 10073
chr12_-_57546121 1.055 ENSMUST00000044380.6
 Foxa1
forkhead box A1
chr17_+_27556613 0.959 ENSMUST00000117600.1
ENSMUST00000114888.3
 Hmga1

high mobility group AT-hook 1

chr17_+_27556668 0.938 ENSMUST00000117254.1
ENSMUST00000118570.1
 Hmga1

high mobility group AT-hook 1

chrM_+_11734 0.890 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr4_-_134767940 0.884 ENSMUST00000037828.6
 Ldlrap1
low density lipoprotein receptor adaptor protein 1
chr1_+_107511416 0.853 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr4_-_58499398 0.851 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr16_-_55283237 0.759 ENSMUST00000036412.3
 Zpld1
zona pellucida like domain containing 1
chr17_+_27556641 0.752 ENSMUST00000119486.1
ENSMUST00000118599.1
 Hmga1

high mobility group AT-hook 1

chr3_-_59220150 0.730 ENSMUST00000170388.1
 P2ry12
purinergic receptor P2Y, G-protein coupled 12
chr2_-_160619971 0.724 ENSMUST00000109473.1
 Gm14221
predicted gene 14221

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 108 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 3.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 2.6 GO:0006284 base-excision repair(GO:0006284)
0.2 1.3 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 1.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 1.3 GO:0042491 auditory receptor cell differentiation(GO:0042491)
0.1 1.2 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 1.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 1.2 GO:0043488 regulation of mRNA stability(GO:0043488)
0.4 1.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743) alveolar secondary septum development(GO:0061144)
0.0 1.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.3 0.9 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118)
0.2 0.9 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 0.8 GO:0021764 amygdala development(GO:0021764)
0.2 0.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0 0.7 GO:0006270 DNA replication initiation(GO:0006270)
0.0 0.7 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 0.7 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 0.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.6 GO:0006570 tyrosine metabolic process(GO:0006570)
0.2 0.5 GO:1904959 regulation of electron carrier activity(GO:1904732) regulation of cytochrome-c oxidase activity(GO:1904959)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 1.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 1.5 GO:0042788 polysomal ribosome(GO:0042788)
0.3 1.3 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 1.1 GO:0070469 respiratory chain(GO:0070469)
0.1 1.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.0 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 0.9 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.9 GO:0005902 microvillus(GO:0005902)
0.1 0.6 GO:0002177 manchette(GO:0002177)
0.0 0.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 0.5 GO:0045179 apical cortex(GO:0045179)
0.1 0.4 GO:0005584 collagen type I trimer(GO:0005584)
0.1 0.4 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.4 GO:0005859 muscle myosin complex(GO:0005859)
0.1 0.4 GO:0005796 Golgi lumen(GO:0005796)
0.1 0.4 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.4 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.4 GO:0005916 fascia adherens(GO:0005916)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 2.6 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.3 2.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 1.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 1.5 GO:0017091 AU-rich element binding(GO:0017091)
0.2 1.3 GO:0000150 recombinase activity(GO:0000150)
0.0 1.2 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.9 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 0.9 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled adenosine receptor activity(GO:0001609) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 0.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 0.6 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.0 0.6 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.5 GO:0015254 glycerol channel activity(GO:0015254)
0.1 0.5 GO:0016531 copper chaperone activity(GO:0016531)
0.0 0.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.8 PID_IL12_2PATHWAY IL12-mediated signaling events
0.0 2.7 PID_IL4_2PATHWAY IL4-mediated signaling events
0.0 1.0 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.7 PID_MYC_PATHWAY C-MYC pathway
0.0 0.6 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.6 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.3 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 2.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 2.0 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 1.4 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.2 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 0.9 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.0 0.8 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.8 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.0 0.7 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.7 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 0.5 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.5 REACTOME_AQUAPORIN_MEDIATED_TRANSPORT Genes involved in Aquaporin-mediated transport
0.0 0.5 REACTOME_INHIBITION_OF_INSULIN_SECRETION_BY_ADRENALINE_NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.4 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.0 0.4 REACTOME_PLATELET_ADHESION_TO_EXPOSED_COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.4 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.4 REACTOME_PLATELET_SENSITIZATION_BY_LDL Genes involved in Platelet sensitization by LDL
0.0 0.4 REACTOME_STRIATED_MUSCLE_CONTRACTION Genes involved in Striated Muscle Contraction