Motif ID: Hoxd11_Cdx1_Hoxc11

Z-value: 0.667

Transcription factors associated with Hoxd11_Cdx1_Hoxc11:

Gene SymbolEntrez IDGene Name
Cdx1 ENSMUSG00000024619.8 Cdx1
Hoxc11 ENSMUSG00000001656.3 Hoxc11
Hoxd11 ENSMUSG00000042499.12 Hoxd11



Activity profile for motif Hoxd11_Cdx1_Hoxc11.

activity profile for motif Hoxd11_Cdx1_Hoxc11


Sorted Z-values histogram for motif Hoxd11_Cdx1_Hoxc11

Sorted Z-values for motif Hoxd11_Cdx1_Hoxc11



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxd11_Cdx1_Hoxc11

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_+_159737510 3.181 ENSMUST00000111669.3
 Tnr
tenascin R
chr13_-_84064772 2.624 ENSMUST00000182477.1
 Gm17750
predicted gene, 17750
chr4_+_144893127 2.225 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr17_+_3397189 2.062 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr17_-_91092715 1.921 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
 Nrxn1


neurexin I


chr15_+_81936753 1.867 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr15_+_81936911 1.750 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr4_+_144892813 1.617 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr6_-_13839916 1.477 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr17_+_31433054 1.374 ENSMUST00000136384.1
 Pde9a
phosphodiesterase 9A
chr9_-_55919605 1.342 ENSMUST00000037408.8
 Scaper
S phase cyclin A-associated protein in the ER
chr2_+_32395896 1.253 ENSMUST00000028162.3
 Ptges2
prostaglandin E synthase 2
chr4_+_144893077 1.221 ENSMUST00000154208.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr8_+_57455898 1.071 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr1_-_56969864 0.999 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr13_-_101692624 0.973 ENSMUST00000035532.6
 Pik3r1
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
chr11_+_29463735 0.956 ENSMUST00000155854.1
 Ccdc88a
coiled coil domain containing 88A
chr10_+_116177351 0.929 ENSMUST00000155606.1
ENSMUST00000128399.1
 Ptprr

protein tyrosine phosphatase, receptor type, R

chr3_+_62419668 0.924 ENSMUST00000161057.1
 Arhgef26
Rho guanine nucleotide exchange factor (GEF) 26
chr1_-_56969827 0.908 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 60 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.1 GO:0042572 retinol metabolic process(GO:0042572)
0.0 3.6 GO:0043488 regulation of mRNA stability(GO:0043488)
0.8 3.2 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.6 2.3 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.1 1.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 1.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 1.3 GO:0001516 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.2 1.0 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.1 1.0 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 0.9 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.2 0.9 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.9 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.0 0.9 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.3 0.8 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.2 0.8 GO:0019236 response to pheromone(GO:0019236)
0.1 0.8 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.8 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.8 GO:0007379 segment specification(GO:0007379)
0.1 0.7 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.1 0.6 GO:0090527 actin filament reorganization(GO:0090527)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.1 3.2 GO:0072534 perineuronal net(GO:0072534)
0.3 2.3 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 2.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.8 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 1.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.9 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.8 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.6 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.3 GO:0005882 intermediate filament(GO:0005882)
0.1 0.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:1990421 subtelomeric heterochromatin(GO:1990421) nuclear subtelomeric heterochromatin(GO:1990707)
0.0 0.2 GO:0032437 cuticular plate(GO:0032437)
0.0 0.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 5.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 3.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 3.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.2 3.2 GO:0046625 sphingolipid binding(GO:0046625)
0.2 2.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.6 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.3 1.3 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.0 1.3 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 1.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.1 1.0 GO:0016208 AMP binding(GO:0016208)
0.0 1.0 GO:0043422 protein kinase B binding(GO:0043422)
0.0 1.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.9 GO:0045545 syndecan binding(GO:0045545)
0.0 0.9 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.8 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.8 GO:0031402 sodium ion binding(GO:0031402)
0.0 0.8 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 0.7 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 0.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)

Gene overrepresentation in C2:CP category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.3 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 3.2 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.1 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.1 2.0 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.3 PID_IFNG_PATHWAY IFN-gamma pathway
0.0 1.3 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 1.2 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 1.0 PID_IL5_PATHWAY IL5-mediated signaling events
0.0 1.0 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.8 PID_ATR_PATHWAY ATR signaling pathway
0.1 0.7 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.4 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.3 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.6 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.0 REACTOME_IL_7_SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.7 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.5 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME_IRAK2_MEDIATED_ACTIVATION_OF_TAK1_COMPLEX_UPON_TLR7_8_OR_9_STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.3 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.1 0.2 REACTOME_SEROTONIN_RECEPTORS Genes involved in Serotonin receptors
0.0 0.2 REACTOME_HDL_MEDIATED_LIPID_TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.1 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels