Motif ID: Hoxa10

Z-value: 0.764


Transcription factors associated with Hoxa10:

Gene SymbolEntrez IDGene Name
Hoxa10 ENSMUSG00000000938.11 Hoxa10



Activity profile for motif Hoxa10.

activity profile for motif Hoxa10


Sorted Z-values histogram for motif Hoxa10

Sorted Z-values for motif Hoxa10



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxa10

PNG image of the network

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Top targets:


Showing 1 to 20 of 149 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_67892189 2.094 ENSMUST00000063263.3
 Iqcj
IQ motif containing J
chr17_+_29093763 1.864 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr3_+_102010138 1.734 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr11_+_44617310 1.679 ENSMUST00000081265.5
ENSMUST00000101326.3
ENSMUST00000109268.1
 Ebf1


early B cell factor 1


chr8_+_106935720 1.448 ENSMUST00000047425.3
 Sntb2
syntrophin, basic 2
chrX_+_96455359 1.434 ENSMUST00000033553.7
 Heph
hephaestin
chr10_+_97565436 1.215 ENSMUST00000038160.4
 Lum
lumican
chr9_-_39604124 1.089 ENSMUST00000042485.4
ENSMUST00000141370.1
 AW551984

expressed sequence AW551984

chr2_-_79908428 1.086 ENSMUST00000102652.3
ENSMUST00000102651.3
 Pde1a

phosphodiesterase 1A, calmodulin-dependent

chr17_-_15566421 1.083 ENSMUST00000178455.1
 Gm6686
predicted pseudogene 6686
chr11_-_69822144 0.887 ENSMUST00000045771.6
 Spem1
sperm maturation 1
chr6_-_3494587 0.850 ENSMUST00000049985.8
 Hepacam2
HEPACAM family member 2
chr2_-_79908389 0.796 ENSMUST00000090756.4
 Pde1a
phosphodiesterase 1A, calmodulin-dependent
chr9_-_119825456 0.792 ENSMUST00000070617.7
 Scn11a
sodium channel, voltage-gated, type XI, alpha
chr6_+_34354119 0.706 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr3_+_85915722 0.701 ENSMUST00000054148.7
 Gm9790
predicted gene 9790
chr9_-_96478660 0.675 ENSMUST00000057500.4
 Rnf7
ring finger protein 7
chr9_+_62342449 0.666 ENSMUST00000156461.1
 Anp32a
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr1_+_74713551 0.648 ENSMUST00000027356.5
 Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr9_+_108560422 0.647 ENSMUST00000081111.8
 Impdh2
inosine 5'-phosphate dehydrogenase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.9 GO:0071493 cellular response to UV-B(GO:0071493)
0.1 1.9 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.1 1.7 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.1 1.4 GO:0006825 copper ion transport(GO:0006825)
0.3 1.2 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 1.1 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
0.1 1.1 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.3 0.9 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.0 0.9 GO:0030317 sperm motility(GO:0030317)
0.0 0.8 GO:0051930 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.2 0.7 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.1 0.7 GO:0061470 interleukin-21 production(GO:0032625) T follicular helper cell differentiation(GO:0061470) interleukin-21 secretion(GO:0072619)
0.2 0.6 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 0.6 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 0.6 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.0 0.6 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.6 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.4 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.1 0.4 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.1 0.4 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 1.9 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 1.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4 1.1 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.3 0.8 GO:0044299 C-fiber(GO:0044299)
0.0 0.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.5 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 0.4 GO:0033193 Lsd1/2 complex(GO:0033193)
0.1 0.4 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.0 0.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.3 GO:0044308 axonal spine(GO:0044308)
0.0 0.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.2 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.0 0.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.0 0.2 GO:0000439 core TFIIH complex(GO:0000439)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 1.9 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.3 1.9 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 1.7 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 1.4 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 1.2 GO:0005518 collagen binding(GO:0005518)
0.1 1.1 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.1 0.9 GO:0016936 galactoside binding(GO:0016936)
0.0 0.8 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.0 0.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 0.7 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.2 0.6 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.6 GO:0001851 complement component C3b binding(GO:0001851)
0.1 0.6 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.1 0.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.4 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.4 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.4 GO:0008312 7S RNA binding(GO:0008312)
0.0 0.4 GO:0050692 DBD domain binding(GO:0050692)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.9 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID_NETRIN_PATHWAY Netrin-mediated signaling events
0.0 0.6 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.9 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.1 1.9 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.0 1.7 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.4 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.2 REACTOME_KERATAN_SULFATE_DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.7 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 0.6 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.1 0.6 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.6 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 0.4 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.2 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.2 REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis