Motif ID: Rest

Z-value: 3.598


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77265454_77265549-0.701.2e-03Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Showing 1 to 20 of 83 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_42255704 20.497 ENSMUST00000087123.5
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chr6_-_121473630 15.162 ENSMUST00000046373.5
 Iqsec3
IQ motif and Sec7 domain 3
chr3_-_80802789 12.786 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr5_-_121009510 12.756 ENSMUST00000079204.5
 Rph3a
rabphilin 3A
chr2_-_25319095 11.628 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
 Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr11_+_74619594 11.063 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr11_-_35798884 10.932 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr9_+_40269430 10.439 ENSMUST00000171835.2
 Scn3b
sodium channel, voltage-gated, type III, beta
chr12_-_70347536 10.141 ENSMUST00000110520.2
ENSMUST00000110522.2
ENSMUST00000167755.1
 Trim9


tripartite motif-containing 9


chr7_-_27396542 9.749 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chrX_-_73869804 9.362 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr9_+_40269273 9.264 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr9_+_40269202 9.114 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr1_+_34579693 8.931 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr6_+_8948608 8.224 ENSMUST00000160300.1
 Nxph1
neurexophilin 1
chr18_-_31447383 7.989 ENSMUST00000025110.3
 Syt4
synaptotagmin IV
chr4_-_129121234 7.972 ENSMUST00000030572.3
 Hpca
hippocalcin
chr11_+_80477015 7.518 ENSMUST00000053413.10
ENSMUST00000147694.1
 Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chr9_+_59578192 7.504 ENSMUST00000118549.1
ENSMUST00000034840.3
 Celf6

CUGBP, Elav-like family member 6

chr2_+_132781278 7.197 ENSMUST00000028826.3
 Chgb
chromogranin B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.2 28.8 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
6.4 25.5 GO:0021586 pons maturation(GO:0021586)
1.9 20.5 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
2.0 18.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.6 15.2 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.5 13.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.5 12.8 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.4 12.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
2.2 10.9 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.1 10.8 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.5 10.6 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
1.6 9.7 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.9 9.4 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.5 8.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
2.7 8.0 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.3 7.5 GO:0071625 vocalization behavior(GO:0071625)
0.7 7.1 GO:0048149 behavioral response to ethanol(GO:0048149)
1.7 6.7 GO:0090126 protein complex assembly involved in synapse maturation(GO:0090126)
0.6 6.3 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.0 6.2 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 28.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.6 26.7 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
1.7 20.5 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.5 18.4 GO:0060077 inhibitory synapse(GO:0060077)
4.5 18.0 GO:0044307 dendritic branch(GO:0044307)
0.2 16.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.6 10.9 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.8 10.6 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.3 10.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.8 10.0 GO:0044294 dendritic growth cone(GO:0044294)
1.6 9.7 GO:0008091 spectrin(GO:0008091)
0.1 8.5 GO:0008021 synaptic vesicle(GO:0008021)
0.8 8.0 GO:0044327 dendritic spine head(GO:0044327)
0.5 8.0 GO:0097449 astrocyte projection(GO:0097449)
2.5 7.5 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.7 6.7 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 6.0 GO:0030667 secretory granule membrane(GO:0030667)
0.6 5.7 GO:0032426 stereocilium tip(GO:0032426)
0.0 4.5 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 4.3 GO:0097440 apical dendrite(GO:0097440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.1 28.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.7 20.5 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 19.7 GO:0000149 SNARE binding(GO:0000149)
3.0 18.0 GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.5 15.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 13.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
2.6 12.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.3 12.8 GO:0042301 phosphate ion binding(GO:0042301)
0.7 10.9 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.2 9.7 GO:0030507 spectrin binding(GO:0030507)
1.6 9.4 GO:0033691 sialic acid binding(GO:0033691)
0.2 8.9 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 8.9 GO:0051219 phosphoprotein binding(GO:0051219)
2.0 8.0 GO:0030348 syntaxin-3 binding(GO:0030348)
0.0 8.0 GO:0003779 actin binding(GO:0003779)
0.3 7.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.6 6.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 6.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 5.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 5.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 28.8 PID_P53_DOWNSTREAM_PATHWAY Direct p53 effectors
0.3 12.8 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.2 9.4 PID_INTEGRIN3_PATHWAY Beta3 integrin cell surface interactions
0.2 7.5 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 6.3 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.6 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 47.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.1 30.8 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.5 13.9 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 10.1 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.4 7.5 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.4 6.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.4 5.9 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.2 5.6 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 4.3 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.4 3.5 REACTOME_PRESYNAPTIC_NICOTINIC_ACETYLCHOLINE_RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 1.6 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.5 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.2 0.9 REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.4 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA