Motif ID: Zbtb33_Chd2

Z-value: 1.695

Transcription factors associated with Zbtb33_Chd2:

Gene SymbolEntrez IDGene Name
Chd2 ENSMUSG00000078671.4 Chd2
Zbtb33 ENSMUSG00000048047.3 Zbtb33

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zbtb33mm10_v2_chrX_+_38189829_38189842-0.341.6e-01Click!
Chd2mm10_v2_chr7_-_73537621_73537766-0.116.6e-01Click!


Activity profile for motif Zbtb33_Chd2.

activity profile for motif Zbtb33_Chd2


Sorted Z-values histogram for motif Zbtb33_Chd2

Sorted Z-values for motif Zbtb33_Chd2



Network of associatons between targets according to the STRING database.



First level regulatory network of Zbtb33_Chd2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_3004457 2.658 ENSMUST00000178348.1
 Gm11168
predicted gene 11168
chr11_-_34833631 2.426 ENSMUST00000093191.2
 Spdl1
spindle apparatus coiled-coil protein 1
chr9_+_3015654 2.285 ENSMUST00000099050.3
 Gm10720
predicted gene 10720
chr9_+_3017408 2.174 ENSMUST00000099049.3
 Gm10719
predicted gene 10719
chr5_+_123907175 2.031 ENSMUST00000023869.8
 Denr
density-regulated protein
chr3_+_69004711 2.014 ENSMUST00000042901.8
 Smc4
structural maintenance of chromosomes 4
chr17_+_56040350 1.956 ENSMUST00000002914.8
 Chaf1a
chromatin assembly factor 1, subunit A (p150)
chr4_+_94614483 1.955 ENSMUST00000030311.4
ENSMUST00000107104.2
 Ift74

intraflagellar transport 74

chr2_-_156180135 1.951 ENSMUST00000126992.1
ENSMUST00000146288.1
ENSMUST00000029149.6
ENSMUST00000109587.2
ENSMUST00000109584.1
 Rbm39




RNA binding motif protein 39




chr16_+_48994185 1.884 ENSMUST00000117994.1
ENSMUST00000048374.5
 C330027C09Rik

RIKEN cDNA C330027C09 gene

chr19_+_38930909 1.874 ENSMUST00000025965.5
 Hells
helicase, lymphoid specific
chr9_+_121719172 1.860 ENSMUST00000035112.6
ENSMUST00000182311.1
 Nktr

natural killer tumor recognition sequence

chr11_+_29172890 1.805 ENSMUST00000102856.2
ENSMUST00000020755.5
 Smek2

SMEK homolog 2, suppressor of mek1 (Dictyostelium)

chr3_+_69004969 1.802 ENSMUST00000136502.1
ENSMUST00000107803.1
 Smc4

structural maintenance of chromosomes 4

chr4_+_116685859 1.716 ENSMUST00000129315.1
ENSMUST00000106470.1
 Prdx1

peroxiredoxin 1

chr4_+_116685544 1.707 ENSMUST00000135573.1
ENSMUST00000151129.1
 Prdx1

peroxiredoxin 1

chr12_+_112678803 1.706 ENSMUST00000174780.1
ENSMUST00000169593.1
ENSMUST00000173942.1
 Zbtb42


zinc finger and BTB domain containing 42


chr5_+_45669907 1.662 ENSMUST00000117396.1
 Ncapg
non-SMC condensin I complex, subunit G
chr15_+_39006272 1.517 ENSMUST00000179165.1
ENSMUST00000022906.7
 Fzd6

frizzled homolog 6 (Drosophila)

chrX_-_166440671 1.512 ENSMUST00000049501.8
 Ofd1
oral-facial-digital syndrome 1 gene homolog (human)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 159 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.8 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.2 3.6 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.5 3.4 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 3.1 GO:0006986 response to unfolded protein(GO:0006986)
0.2 2.8 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.0 2.7 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 2.6 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.1 2.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 2.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.5 2.0 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.5 2.0 GO:0002188 translation reinitiation(GO:0002188)
0.3 2.0 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 1.9 GO:2000179 positive regulation of neural precursor cell proliferation(GO:2000179)
0.1 1.8 GO:0030953 astral microtubule organization(GO:0030953)
0.1 1.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.5 1.5 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.5 1.5 GO:2000314 negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314)
0.1 1.5 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.3 1.4 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.3 1.4 GO:0019230 proprioception(GO:0019230)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 6.3 GO:0000796 condensin complex(GO:0000796)
0.2 5.4 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 4.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.4 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 3.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 3.0 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.7 2.0 GO:0033186 CAF-1 complex(GO:0033186)
0.1 1.8 GO:0034451 centriolar satellite(GO:0034451)
0.2 1.6 GO:0097422 tubular endosome(GO:0097422)
0.0 1.6 GO:0005840 ribosome(GO:0005840)
0.1 1.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 1.5 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.0 1.5 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.4 1.3 GO:0035101 FACT complex(GO:0035101)
0.2 1.3 GO:0001740 Barr body(GO:0001740)
0.1 1.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 1.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 1.2 GO:0005827 polar microtubule(GO:0005827)
0.2 1.2 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 5.0 GO:0003697 single-stranded DNA binding(GO:0003697)
0.4 3.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 3.5 GO:0004386 helicase activity(GO:0004386)
0.1 2.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 2.4 GO:0043515 kinetochore binding(GO:0043515)
0.1 2.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 2.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.2 2.0 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 2.0 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 1.9 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.7 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.2 1.6 GO:0034452 dynactin binding(GO:0034452)
0.0 1.6 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 1.5 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.0 1.5 GO:0005507 copper ion binding(GO:0005507)
0.3 1.4 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.3 1.4 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 1.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 1.4 GO:0019209 kinase activator activity(GO:0019209)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.7 PID_AURORA_B_PATHWAY Aurora B signaling
0.1 4.7 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 3.0 ST_B_CELL_ANTIGEN_RECEPTOR B Cell Antigen Receptor
0.0 2.4 PID_PLK1_PATHWAY PLK1 signaling events
0.0 2.4 PID_HDAC_CLASSI_PATHWAY Signaling events mediated by HDAC Class I
0.1 1.7 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.7 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 1.5 PID_AURORA_A_PATHWAY Aurora A signaling
0.0 1.5 PID_VEGFR1_PATHWAY VEGFR1 specific signals
0.0 1.2 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.0 PID_BARD1_PATHWAY BARD1 signaling events
0.0 0.8 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.7 PID_IL2_PI3K_PATHWAY IL2 signaling events mediated by PI3K
0.0 0.6 PID_SMAD2_3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.5 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.4 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.3 ST_GA12_PATHWAY G alpha 12 Pathway
0.0 0.2 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 4.7 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 4.3 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 4.1 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 2.1 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES Genes involved in Recruitment of mitotic centrosome proteins and complexes
0.0 1.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.8 REACTOME_EXTENSION_OF_TELOMERES Genes involved in Extension of Telomeres
0.1 1.5 REACTOME_CONVERSION_FROM_APC_C_CDC20_TO_APC_C_CDH1_IN_LATE_ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 1.4 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.4 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.0 1.3 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.2 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 1.2 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 1.1 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1 0.9 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 0.8 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.8 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.7 REACTOME_FANCONI_ANEMIA_PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.7 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen