Motif ID: Pax6

Z-value: 0.817


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105675429_105675449-0.428.6e-02Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Showing 1 to 20 of 90 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_103422010 2.659 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr11_-_95587691 1.300 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr19_-_57118981 1.072 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr19_-_57118897 1.049 ENSMUST00000111526.1
 Ablim1
actin-binding LIM protein 1
chr4_+_85205417 0.906 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr17_+_43016536 0.889 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr10_+_26229707 0.791 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr3_-_89245159 0.652 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr16_+_4968936 0.650 ENSMUST00000090457.5
 4930451G09Rik
RIKEN cDNA 4930451G09 gene
chr8_-_57962564 0.637 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr6_-_60829826 0.598 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr18_-_34373313 0.578 ENSMUST00000006027.5
 Reep5
receptor accessory protein 5
chr1_-_38836090 0.549 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr5_+_149265035 0.522 ENSMUST00000130144.1
ENSMUST00000071130.3
 Alox5ap

arachidonate 5-lipoxygenase activating protein

chr15_+_84669565 0.427 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr18_+_37447641 0.366 ENSMUST00000052387.3
 Pcdhb14
protocadherin beta 14
chr13_+_64432479 0.356 ENSMUST00000021939.6
 Cdk20
cyclin-dependent kinase 20
chr5_-_142906702 0.347 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
 Actb


actin, beta


chr13_-_113618549 0.343 ENSMUST00000109241.3
 Snx18
sorting nexin 18
chr3_-_89245005 0.340 ENSMUST00000107464.1
 Trim46
tripartite motif-containing 46

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.4 1.3 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.0 1.0 GO:0099612 protein localization to axon(GO:0099612)
0.3 0.9 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.1 0.9 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.6 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)
0.2 0.5 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.0 0.4 GO:0038203 TORC2 signaling(GO:0038203)
0.1 0.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 0.3 GO:0090204 protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.1 0.3 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
0.1 0.3 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.1 0.3 GO:0007603 phototransduction, visible light(GO:0007603)
0.0 0.3 GO:0036089 cleavage furrow formation(GO:0036089)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.2 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.2 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.2 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.2 GO:0035542 regulation of SNARE complex assembly(GO:0035542)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.2 1.0 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.1 0.3 GO:0001533 cornified envelope(GO:0001533)
0.0 0.3 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0000145 exocyst(GO:0000145)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0048406 neurotrophin TRKA receptor binding(GO:0005168) nerve growth factor binding(GO:0048406)
0.2 1.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 0.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 0.3 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 0.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.3 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.1 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)

Gene overrepresentation in C2:CP category:

Showing 1 to 5 of 5 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.4 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 1.3 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.6 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 0.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.3 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.3 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.2 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.2 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins