Motif ID: Pax6

Z-value: 0.817


Transcription factors associated with Pax6:

Gene SymbolEntrez IDGene Name
Pax6 ENSMUSG00000027168.15 Pax6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pax6mm10_v2_chr2_+_105675429_105675449-0.428.6e-02Click!


Activity profile for motif Pax6.

activity profile for motif Pax6


Sorted Z-values histogram for motif Pax6

Sorted Z-values for motif Pax6



Network of associatons between targets according to the STRING database.



First level regulatory network of Pax6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_103422010 2.659 ENSMUST00000182089.1
 Gm26992
predicted gene, 26992
chr11_-_95587691 1.300 ENSMUST00000000122.6
 Ngfr
nerve growth factor receptor (TNFR superfamily, member 16)
chr19_-_57118981 1.072 ENSMUST00000111528.1
ENSMUST00000111529.1
ENSMUST00000104902.2
 Ablim1


actin-binding LIM protein 1


chr19_-_57118897 1.049 ENSMUST00000111526.1
 Ablim1
actin-binding LIM protein 1
chr4_+_85205417 0.906 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr17_+_43016536 0.889 ENSMUST00000024708.4
 Tnfrsf21
tumor necrosis factor receptor superfamily, member 21
chr10_+_26229707 0.791 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr3_-_89245159 0.652 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr16_+_4968936 0.650 ENSMUST00000090457.5
 4930451G09Rik
RIKEN cDNA 4930451G09 gene
chr8_-_57962564 0.637 ENSMUST00000098757.3
 Galntl6
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
chr6_-_60829826 0.598 ENSMUST00000163779.1
 Snca
synuclein, alpha
chr18_-_34373313 0.578 ENSMUST00000006027.5
 Reep5
receptor accessory protein 5
chr1_-_38836090 0.549 ENSMUST00000147695.1
 Lonrf2
LON peptidase N-terminal domain and ring finger 2
chr5_+_149265035 0.522 ENSMUST00000130144.1
ENSMUST00000071130.3
 Alox5ap

arachidonate 5-lipoxygenase activating protein

chr15_+_84669565 0.427 ENSMUST00000171460.1
 Prr5
proline rich 5 (renal)
chr18_+_37447641 0.366 ENSMUST00000052387.3
 Pcdhb14
protocadherin beta 14
chr13_+_64432479 0.356 ENSMUST00000021939.6
 Cdk20
cyclin-dependent kinase 20
chr5_-_142906702 0.347 ENSMUST00000167721.1
ENSMUST00000163829.1
ENSMUST00000100497.4
 Actb


actin, beta


chr13_-_113618549 0.343 ENSMUST00000109241.3
 Snx18
sorting nexin 18
chr3_-_89245005 0.340 ENSMUST00000107464.1
 Trim46
tripartite motif-containing 46
chr6_-_88045190 0.331 ENSMUST00000113596.1
ENSMUST00000113600.3
 Rab7

RAB7, member RAS oncogene family

chr15_-_101850778 0.328 ENSMUST00000023790.3
 Krt1
keratin 1
chr9_+_50775347 0.319 ENSMUST00000159576.1
 Alg9
asparagine-linked glycosylation 9 (alpha 1,2 mannosyltransferase)
chr9_+_15239045 0.312 ENSMUST00000034413.6
 Vstm5
V-set and transmembrane domain containing 5
chr13_-_110280103 0.309 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr2_+_163602294 0.302 ENSMUST00000171696.1
ENSMUST00000109408.3
 Ttpal

tocopherol (alpha) transfer protein-like

chr4_+_155491353 0.298 ENSMUST00000165335.1
ENSMUST00000105616.3
ENSMUST00000030940.7
 Gnb1


guanine nucleotide binding protein (G protein), beta 1


chr8_+_105860634 0.290 ENSMUST00000008594.7
 Nutf2
nuclear transport factor 2
chr14_+_34170640 0.289 ENSMUST00000104925.3
 Rpl23a-ps3
ribosomal protein L23A, pseudogene 3
chr6_-_118780324 0.270 ENSMUST00000112793.3
ENSMUST00000075591.6
ENSMUST00000078320.7
ENSMUST00000112790.2
 Cacna1c



calcium channel, voltage-dependent, L type, alpha 1C subunit



chr11_-_67965631 0.268 ENSMUST00000021287.5
ENSMUST00000126766.1
 Wdr16

WD repeat domain 16

chr1_+_156040909 0.262 ENSMUST00000065648.8
ENSMUST00000097526.2
 Tor1aip2

torsin A interacting protein 2

chr16_-_22857514 0.232 ENSMUST00000004576.6
 Tbccd1
TBCC domain containing 1
chr12_-_45074457 0.232 ENSMUST00000053768.6
 Stxbp6
syntaxin binding protein 6 (amisyn)
chr5_-_18360384 0.215 ENSMUST00000074694.5
 Gnai1
guanine nucleotide binding protein (G protein), alpha inhibiting 1
chr2_+_163602331 0.212 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr8_-_80880479 0.209 ENSMUST00000034150.8
 Gab1
growth factor receptor bound protein 2-associated protein 1
chr9_-_62811592 0.204 ENSMUST00000034775.8
 Fem1b
feminization 1 homolog b (C. elegans)
chr11_-_6200411 0.201 ENSMUST00000066496.3
 Nudcd3
NudC domain containing 3
chr16_+_20498817 0.195 ENSMUST00000003320.6
 Eif2b5
eukaryotic translation initiation factor 2B, subunit 5 epsilon
chr6_-_145048809 0.190 ENSMUST00000032402.5
 Bcat1
branched chain aminotransferase 1, cytosolic
chr17_-_43543639 0.189 ENSMUST00000178772.1
 Ankrd66
ankyrin repeat domain 66
chr12_+_112976471 0.165 ENSMUST00000165079.1
ENSMUST00000002880.6
 Btbd6

BTB (POZ) domain containing 6

chr17_+_34604262 0.163 ENSMUST00000174041.1
 Agpat1
1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha)
chr2_+_105904629 0.162 ENSMUST00000037499.5
 Immp1l
IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
chr11_+_67966442 0.159 ENSMUST00000021286.4
ENSMUST00000108675.1
 Stx8

syntaxin 8

chr17_-_33718591 0.147 ENSMUST00000174040.1
ENSMUST00000173015.1
ENSMUST00000066121.6
ENSMUST00000172767.1
ENSMUST00000173329.1
 March2




membrane-associated ring finger (C3HC4) 2




chr1_-_195131536 0.144 ENSMUST00000075451.6
 Cr1l
complement component (3b/4b) receptor 1-like
chr7_+_12897800 0.142 ENSMUST00000055528.4
ENSMUST00000117189.1
ENSMUST00000120809.1
ENSMUST00000119989.1
 Zscan22



zinc finger and SCAN domain containing 22



chr17_+_25366550 0.140 ENSMUST00000069616.7
 Tpsb2
tryptase beta 2
chr3_+_65109343 0.140 ENSMUST00000159525.1
ENSMUST00000049230.8
 Kcnab1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr19_+_6400611 0.134 ENSMUST00000113467.1
 Rasgrp2
RAS, guanyl releasing protein 2
chr4_-_3835595 0.131 ENSMUST00000138502.1
 Rps20
ribosomal protein S20
chr7_+_5051515 0.123 ENSMUST00000069324.5
 Zfp580
zinc finger protein 580
chr13_-_53377355 0.122 ENSMUST00000021920.6
 Sptlc1
serine palmitoyltransferase, long chain base subunit 1
chr9_+_105642957 0.122 ENSMUST00000065778.6
 Pik3r4
phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 4, p150
chr17_-_57059795 0.114 ENSMUST00000040280.7
 Slc25a23
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
chr11_+_45852031 0.106 ENSMUST00000109261.3
ENSMUST00000109260.1
 Clint1

clathrin interactor 1

chr13_-_66905322 0.093 ENSMUST00000021993.4
 Uqcrb
ubiquinol-cytochrome c reductase binding protein
chr8_+_109614417 0.089 ENSMUST00000109242.1
ENSMUST00000057344.2
 Pkd1l3

polycystic kidney disease 1 like 3

chr9_+_92250039 0.086 ENSMUST00000093801.3
 Plscr1
phospholipid scramblase 1
chr13_-_24937585 0.085 ENSMUST00000037615.6
 Aldh5a1
aldhehyde dehydrogenase family 5, subfamily A1
chr10_+_80356459 0.084 ENSMUST00000039836.8
ENSMUST00000105351.1
 Plk5

polo-like kinase 5

chr2_-_162661075 0.081 ENSMUST00000109442.1
ENSMUST00000109445.2
ENSMUST00000109443.1
ENSMUST00000109441.1
 Ptprt



protein tyrosine phosphatase, receptor type, T



chr8_+_31150307 0.078 ENSMUST00000098842.2
 Tti2
TELO2 interacting protein 2
chr10_+_94550852 0.073 ENSMUST00000148910.1
ENSMUST00000117460.1
 Tmcc3

transmembrane and coiled coil domains 3

chr14_-_43819639 0.073 ENSMUST00000100691.3
 Ear1
eosinophil-associated, ribonuclease A family, member 1
chr10_-_127030813 0.068 ENSMUST00000040560.4
 Tsfm
Ts translation elongation factor, mitochondrial
chr6_-_113377376 0.063 ENSMUST00000043333.2
 Tada3
transcriptional adaptor 3
chr4_-_139832920 0.063 ENSMUST00000174681.1
 Pax7
paired box gene 7
chr15_+_103272893 0.060 ENSMUST00000100162.3
 Copz1
coatomer protein complex, subunit zeta 1
chr1_-_180813534 0.059 ENSMUST00000159789.1
ENSMUST00000081026.4
 H3f3a

H3 histone, family 3A

chr11_+_78328415 0.058 ENSMUST00000048073.8
 Pigs
phosphatidylinositol glycan anchor biosynthesis, class S
chr6_+_123229843 0.057 ENSMUST00000112554.2
ENSMUST00000024118.4
ENSMUST00000117130.1
 Clec4n


C-type lectin domain family 4, member n


chr4_+_129820702 0.048 ENSMUST00000165853.1
 Ptp4a2
protein tyrosine phosphatase 4a2
chr1_+_43092588 0.045 ENSMUST00000039080.3
 8430432A02Rik
RIKEN cDNA 8430432A02 gene
chrX_+_36795642 0.045 ENSMUST00000016463.3
 Slc25a5
solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5
chr9_-_10904697 0.044 ENSMUST00000162484.1
 Cntn5
contactin 5
chr2_-_75981967 0.036 ENSMUST00000099994.3
 Ttc30a1
tetratricopeptide repeat domain 30A1
chr11_-_104550392 0.035 ENSMUST00000106962.2
 Cdc27
cell division cycle 27
chr15_-_35938186 0.026 ENSMUST00000014457.8
 Cox6c
cytochrome c oxidase subunit VIc
chr7_-_12775658 0.023 ENSMUST00000046245.5
 Zscan18
zinc finger and SCAN domain containing 18
chr9_+_64179289 0.020 ENSMUST00000034965.6
 Snapc5
small nuclear RNA activating complex, polypeptide 5
chr19_+_34290653 0.018 ENSMUST00000025691.5
ENSMUST00000112472.2
 Fas

Fas (TNF receptor superfamily member 6)

chr7_+_141228766 0.013 ENSMUST00000106027.2
 Phrf1
PHD and ring finger domains 1
chr10_-_127030789 0.011 ENSMUST00000120547.1
ENSMUST00000152054.1
 Tsfm

Ts translation elongation factor, mitochondrial

chr11_+_60699718 0.010 ENSMUST00000052346.3
 Llgl1
lethal giant larvae homolog 1 (Drosophila)
chr15_+_6299797 0.006 ENSMUST00000159046.1
ENSMUST00000161040.1
 Dab2

disabled 2, mitogen-responsive phosphoprotein

chr2_-_105904484 0.006 ENSMUST00000122965.1
 Elp4
elongation protein 4 homolog (S. cerevisiae)
chr13_-_97760588 0.005 ENSMUST00000074072.3
 Gm10260
predicted gene 10260

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.3 0.9 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-10 secretion(GO:2001180)
0.2 0.5 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.1 0.6 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)
0.1 0.9 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.1 0.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 0.3 GO:0090204 protein localization to nuclear pore(GO:0090204) negative regulation of vascular endothelial growth factor production(GO:1904046)
0.1 0.3 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
0.1 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1 0.3 GO:0060083 smooth muscle contraction involved in micturition(GO:0060083)
0.1 0.3 GO:0007603 phototransduction, visible light(GO:0007603)
0.1 0.2 GO:0051661 maintenance of centrosome location(GO:0051661)
0.1 0.2 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.3 GO:0036089 cleavage furrow formation(GO:0036089)
0.0 0.4 GO:0038203 TORC2 signaling(GO:0038203)
0.0 1.0 GO:0099612 protein localization to axon(GO:0099612)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.1 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.1 GO:0006667 sphinganine metabolic process(GO:0006667)
0.0 0.1 GO:0097274 urea homeostasis(GO:0097274)
0.0 0.2 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.0 0.2 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782) regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.0 0.1 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0 0.1 GO:0006083 acetate metabolic process(GO:0006083)
0.0 0.2 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 2.1 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 0.0 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.1 GO:0030242 pexophagy(GO:0030242)
0.0 0.2 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.2 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1990769 proximal neuron projection(GO:1990769)
0.1 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.3 GO:0001533 cornified envelope(GO:0001533)
0.1 0.2 GO:0042720 mitochondrial inner membrane peptidase complex(GO:0042720)
0.0 1.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.1 GO:0034272 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.0 0.3 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.3 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.1 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 2.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.2 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0000145 exocyst(GO:0000145)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0050544 arachidonic acid binding(GO:0050544)
0.1 0.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.1 1.3 GO:0048406 neurotrophin TRKA receptor binding(GO:0005168) nerve growth factor binding(GO:0048406)
0.1 0.3 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 0.3 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 0.1 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 0.3 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0 0.2 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.0 0.1 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.2 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.2 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.1 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.2 GO:0005123 death receptor binding(GO:0005123)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.3 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.4 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY EGF receptor (ErbB1) signaling pathway
0.0 0.9 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.6 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.1 2.1 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.1 0.3 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.9 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.2 REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.0 0.6 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.2 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.6 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.3 REACTOME_BIOSYNTHESIS_OF_THE_N_GLYCAN_PRECURSOR_DOLICHOL_LIPID_LINKED_OLIGOSACCHARIDE_LLO_AND_TRANSFER_TO_A_NASCENT_PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.3 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC