Motif ID: Pou5f1

Z-value: 1.898


Transcription factors associated with Pou5f1:

Gene SymbolEntrez IDGene Name
Pou5f1 ENSMUSG00000024406.10 Pou5f1



Activity profile for motif Pou5f1.

activity profile for motif Pou5f1


Sorted Z-values histogram for motif Pou5f1

Sorted Z-values for motif Pou5f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou5f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 10.243 ENSMUST00000164163.1
 Sla
src-like adaptor
chr4_-_64046925 8.830 ENSMUST00000107377.3
 Tnc
tenascin C
chr14_-_79771305 6.552 ENSMUST00000039568.5
 Pcdh8
protocadherin 8
chr8_-_84773381 6.331 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr7_+_91090697 5.977 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr10_+_85386813 5.958 ENSMUST00000105307.1
ENSMUST00000020231.3
 Btbd11

BTB (POZ) domain containing 11

chr6_+_136518820 5.894 ENSMUST00000032335.6
 Atf7ip
activating transcription factor 7 interacting protein
chr7_+_91090728 5.834 ENSMUST00000074273.3
 Dlg2
discs, large homolog 2 (Drosophila)
chr8_+_54954728 5.750 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr12_+_89812467 5.713 ENSMUST00000110133.2
ENSMUST00000110130.2
 Nrxn3

neurexin III

chr12_+_29528382 5.281 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr14_-_102982630 5.274 ENSMUST00000184744.1
 KCTD12
mmu-mir-5130
chr15_-_100599864 5.201 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr11_+_57011945 4.956 ENSMUST00000094179.4
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr11_-_69605829 4.951 ENSMUST00000047889.6
 Atp1b2
ATPase, Na+/K+ transporting, beta 2 polypeptide
chr11_+_57011798 4.880 ENSMUST00000036315.9
 Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
chr5_+_66968559 4.699 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr5_+_66968961 4.664 ENSMUST00000132991.1
 Limch1
LIM and calponin homology domains 1
chr14_-_88471396 4.654 ENSMUST00000061628.5
 Pcdh20
protocadherin 20
chr7_+_87803815 4.568 ENSMUST00000125009.1
ENSMUST00000155358.1
 Grm5

glutamate receptor, metabotropic 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.2 14.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.8 11.8 GO:0045161 neuronal ion channel clustering(GO:0045161)
0.3 10.4 GO:0007616 long-term memory(GO:0007616)
0.2 10.2 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.3 9.7 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
2.2 8.8 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
2.0 7.9 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.2 7.0 GO:0030325 adrenal gland development(GO:0030325)
0.1 6.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.6 6.5 GO:0042118 endothelial cell activation(GO:0042118)
0.2 6.5 GO:0070306 lens fiber cell differentiation(GO:0070306)
2.1 6.3 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
0.6 6.3 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5 6.3 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 6.0 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.4 5.9 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.3 5.7 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 5.4 GO:0006376 mRNA splice site selection(GO:0006376)
1.2 5.0 GO:1903288 positive regulation of potassium ion import(GO:1903288)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 12.2 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.7 11.6 GO:0098839 postsynaptic density membrane(GO:0098839) postsynaptic specialization membrane(GO:0099634)
0.1 10.8 GO:0005905 clathrin-coated pit(GO:0005905)
1.6 9.8 GO:0044308 axonal spine(GO:0044308)
0.6 8.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 7.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 7.8 GO:0005769 early endosome(GO:0005769)
0.0 7.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 7.4 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 6.8 GO:0031225 anchored component of membrane(GO:0031225)
0.1 6.1 GO:0042734 presynaptic membrane(GO:0042734)
0.1 5.9 GO:0044295 axonal growth cone(GO:0044295)
0.1 5.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 5.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.7 5.0 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 4.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 4.9 GO:0030315 T-tubule(GO:0030315)
0.2 4.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 3.5 GO:0043235 receptor complex(GO:0043235)
1.1 3.2 GO:0031088 platelet dense granule membrane(GO:0031088)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 93 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 17.2 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.5 11.8 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 10.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 10.2 GO:0003779 actin binding(GO:0003779)
0.2 9.3 GO:0005246 calcium channel regulator activity(GO:0005246)
1.5 8.8 GO:0045545 syndecan binding(GO:0045545)
2.6 7.9 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
0.1 6.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.6 6.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.9 6.4 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.1 6.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
2.1 6.3 GO:0002153 steroid receptor RNA activator RNA binding(GO:0002153)
0.0 6.3 GO:0016887 ATPase activity(GO:0016887)
0.0 6.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 5.5 GO:0005262 calcium channel activity(GO:0005262)
0.1 5.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.4 5.3 GO:0050897 cobalt ion binding(GO:0050897)
0.5 5.0 GO:0008556 sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556)
0.3 4.9 GO:0031402 sodium ion binding(GO:0031402)
0.3 4.6 GO:0045499 chemorepellent activity(GO:0045499)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.1 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.2 10.6 PID_EPHB_FWD_PATHWAY EPHB forward signaling
0.3 8.8 PID_INTEGRIN_A9B1_PATHWAY Alpha9 beta1 integrin signaling events
0.2 8.2 PID_HNF3A_PATHWAY FOXA1 transcription factor network
0.3 7.9 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2 6.9 PID_RXR_VDR_PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 6.5 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.1 5.1 PID_NFAT_TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 4.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 4.3 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 4.2 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 3.9 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.1 3.9 PID_SHP2_PATHWAY SHP2 signaling
0.1 3.8 PID_ERBB4_PATHWAY ErbB4 signaling events
0.1 3.4 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.1 3.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 2.7 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.1 2.6 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 2.3 PID_LKB1_PATHWAY LKB1 signaling events
0.1 2.0 PID_ALK1_PATHWAY ALK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 16.9 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1 10.2 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS Genes involved in Integrin cell surface interactions
0.3 9.5 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 8.4 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 6.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 4.8 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.2 4.7 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.3 4.3 REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX Genes involved in Degradation of the extracellular matrix
0.2 3.6 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 3.2 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 2.7 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.2 2.2 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 2.2 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 2.2 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.5 2.0 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.1 2.0 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.8 REACTOME_SYNTHESIS_OF_PC Genes involved in Synthesis of PC
0.0 1.8 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.3 REACTOME_PYRIMIDINE_CATABOLISM Genes involved in Pyrimidine catabolism
0.1 1.1 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle