Motif ID: Nr1i2

Z-value: 0.803


Transcription factors associated with Nr1i2:

Gene SymbolEntrez IDGene Name
Nr1i2 ENSMUSG00000022809.4 Nr1i2



Activity profile for motif Nr1i2.

activity profile for motif Nr1i2


Sorted Z-values histogram for motif Nr1i2

Sorted Z-values for motif Nr1i2



Network of associatons between targets according to the STRING database.



First level regulatory network of Nr1i2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_91269759 2.433 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr16_+_41532999 1.929 ENSMUST00000099761.3
 Lsamp
limbic system-associated membrane protein
chr11_+_42419729 1.870 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr16_+_11406618 1.765 ENSMUST00000122168.1
 Snx29
sorting nexin 29
chr2_+_71528657 1.656 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr9_-_53975246 1.606 ENSMUST00000048409.7
 Elmod1
ELMO/CED-12 domain containing 1
chr1_-_162478004 1.573 ENSMUST00000086074.5
ENSMUST00000070330.7
 Dnm3

dynamin 3

chr5_-_136565432 1.558 ENSMUST00000176172.1
 Cux1
cut-like homeobox 1
chr6_+_114131229 1.540 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11
chr3_-_127225917 1.499 ENSMUST00000182064.1
ENSMUST00000182662.1
 Ank2

ankyrin 2, brain

chr17_+_55445375 1.489 ENSMUST00000133899.1
ENSMUST00000086878.3
 St6gal2

beta galactoside alpha 2,6 sialyltransferase 2

chr4_+_54945038 1.483 ENSMUST00000133895.1
 Zfp462
zinc finger protein 462
chr3_-_127225847 1.470 ENSMUST00000182726.1
ENSMUST00000182779.1
 Ank2

ankyrin 2, brain

chr17_-_37023349 1.402 ENSMUST00000102665.4
 Mog
myelin oligodendrocyte glycoprotein
chr16_+_23290464 1.357 ENSMUST00000115335.1
 St6gal1
beta galactoside alpha 2,6 sialyltransferase 1
chr7_-_98162318 1.330 ENSMUST00000107112.1
 Capn5
calpain 5
chr16_+_21891969 1.280 ENSMUST00000042065.6
 Map3k13
mitogen-activated protein kinase kinase kinase 13
chr1_-_22315792 1.234 ENSMUST00000164877.1
 Rims1
regulating synaptic membrane exocytosis 1
chr16_+_10545390 1.231 ENSMUST00000115827.1
ENSMUST00000038145.6
ENSMUST00000150894.1
 Clec16a


C-type lectin domain family 16, member A


chr9_-_121495678 1.201 ENSMUST00000035120.4
 Cck
cholecystokinin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 192 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 4.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 3.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 1.9 GO:0071420 cellular response to histamine(GO:0071420)
0.0 1.9 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.4 1.8 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.1 1.8 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.6 1.7 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.1 1.7 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.4 1.6 GO:0098884 postsynaptic neurotransmitter receptor internalization(GO:0098884)
0.1 1.6 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.2 1.5 GO:0035826 rubidium ion transport(GO:0035826)
0.1 1.5 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.3 1.4 GO:2000110 protein sialylation(GO:1990743) negative regulation of macrophage apoptotic process(GO:2000110)
0.1 1.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 1.4 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 1.3 GO:0032096 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.1 1.3 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 1.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.3 1.2 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.1 1.2 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0060076 excitatory synapse(GO:0060076)
0.2 4.2 GO:0031430 M band(GO:0031430)
0.1 1.9 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 1.8 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.4 1.6 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.4 1.6 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 1.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 1.4 GO:0000138 Golgi trans cisterna(GO:0000138)
0.1 1.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 1.3 GO:0030424 axon(GO:0030424)
0.2 1.2 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.1 1.2 GO:0043203 axon hillock(GO:0043203)
0.1 1.1 GO:0032279 asymmetric synapse(GO:0032279)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.0 GO:0030118 clathrin coat(GO:0030118)
0.0 0.9 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.9 GO:0051233 spindle midzone(GO:0051233)
0.0 0.9 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 0.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 0.8 GO:0097440 apical dendrite(GO:0097440)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.6 GO:0030507 spectrin binding(GO:0030507)
0.6 2.8 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 2.2 GO:0032452 histone demethylase activity(GO:0032452)
0.5 1.9 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.0 1.8 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.7 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 1.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.5 1.6 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
0.5 1.5 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.1 1.5 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.4 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 1.3 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 1.3 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.3 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.2 GO:0042169 SH2 domain binding(GO:0042169)
0.0 1.2 GO:0003774 motor activity(GO:0003774)
0.1 1.1 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.1 GO:0004697 protein kinase C activity(GO:0004697)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 1.5 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 1.4 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.0 1.4 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.2 PID_PI3K_PLC_TRK_PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.2 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 1.1 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 1.1 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.9 PID_REELIN_PATHWAY Reelin signaling pathway
0.0 0.9 PID_ATR_PATHWAY ATR signaling pathway
0.1 0.8 PID_ERBB_NETWORK_PATHWAY ErbB receptor signaling network
0.0 0.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.6 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.6 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 0.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.0 0.6 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.5 PID_REG_GR_PATHWAY Glucocorticoid receptor regulatory network
0.0 0.4 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.3 ST_ADRENERGIC Adrenergic Pathway
0.0 0.2 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.0 2.4 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK Genes involved in Gastrin-CREB signalling pathway via PKC and MAPK
0.1 2.2 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.1 1.8 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.8 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.2 1.5 REACTOME_NA_CL_DEPENDENT_NEUROTRANSMITTER_TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.4 REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.4 REACTOME_SIGNALING_BY_FGFR1_FUSION_MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.1 1.3 REACTOME_INSULIN_RECEPTOR_RECYCLING Genes involved in Insulin receptor recycling
0.1 1.2 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 1.1 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.0 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.0 REACTOME_INTEGRIN_ALPHAIIB_BETA3_SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.1 0.9 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.9 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.1 0.7 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 0.6 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.6 REACTOME_NEPHRIN_INTERACTIONS Genes involved in Nephrin interactions
0.0 0.6 REACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.6 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)