Motif ID: Ppard

Z-value: 0.618


Transcription factors associated with Ppard:

Gene SymbolEntrez IDGene Name
Ppard ENSMUSG00000002250.9 Ppard

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ppardmm10_v2_chr17_+_28272191_28272205-0.262.9e-01Click!


Activity profile for motif Ppard.

activity profile for motif Ppard


Sorted Z-values histogram for motif Ppard

Sorted Z-values for motif Ppard



Network of associatons between targets according to the STRING database.



First level regulatory network of Ppard

PNG image of the network

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Top targets:


Showing 1 to 20 of 68 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_87948666 5.696 ENSMUST00000005019.5
Crabp2
cellular retinoic acid binding protein II
chr3_-_8923796 1.171 ENSMUST00000042148.5
Mrps28
mitochondrial ribosomal protein S28
chr9_-_57262591 1.077 ENSMUST00000034846.5
1700017B05Rik
RIKEN cDNA 1700017B05 gene
chr4_+_118429701 1.015 ENSMUST00000067896.3
Elovl1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr9_-_51278540 0.983 ENSMUST00000114427.3
Gm684
predicted gene 684
chr4_+_59581563 0.976 ENSMUST00000030078.5
Hsdl2
hydroxysteroid dehydrogenase like 2
chr11_-_4704334 0.964 ENSMUST00000058407.5
Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr5_-_115119277 0.957 ENSMUST00000031524.7
Acads
acyl-Coenzyme A dehydrogenase, short chain
chr4_+_59581645 0.871 ENSMUST00000107528.1
Hsdl2
hydroxysteroid dehydrogenase like 2
chr11_+_70657687 0.829 ENSMUST00000134087.1
ENSMUST00000170716.1
Eno3

enolase 3, beta muscle

chr10_-_13324160 0.814 ENSMUST00000105545.4
Phactr2
phosphatase and actin regulator 2
chr19_+_37207528 0.790 ENSMUST00000024078.7
ENSMUST00000112391.1
March5

membrane-associated ring finger (C3HC4) 5

chr17_-_34028044 0.771 ENSMUST00000045467.7
ENSMUST00000114303.3
H2-Ke6

H2-K region expressed gene 6

chr15_-_89425856 0.757 ENSMUST00000109313.2
Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr2_-_73911323 0.701 ENSMUST00000111996.1
ENSMUST00000018914.2
Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr3_-_138131356 0.695 ENSMUST00000029805.8
Mttp
microsomal triglyceride transfer protein
chr7_+_43444104 0.677 ENSMUST00000004729.3
Etfb
electron transferring flavoprotein, beta polypeptide
chr8_-_111393810 0.627 ENSMUST00000038475.8
Fa2h
fatty acid 2-hydroxylase
chr4_+_98546919 0.606 ENSMUST00000030290.7
Inadl
InaD-like (Drosophila)
chr4_+_118409331 0.602 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 5.7 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.1 1.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.0 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 1.0 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 1.0 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.8 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.8 GO:0090344 negative regulation of cell aging(GO:0090344)
0.1 0.7 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.6 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.1 0.6 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.5 0.5 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.1 0.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.4 GO:0046322 very long-chain fatty acid catabolic process(GO:0042760) negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.4 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.1 0.3 GO:0045004 DNA replication proofreading(GO:0045004)
0.1 0.3 GO:0006014 D-ribose metabolic process(GO:0006014)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)

Gene overrepresentation in cellular_component category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 1.2 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 1.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 0.7 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.6 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 0.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.1 0.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.1 0.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.2 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 5.7 GO:0019841 retinol binding(GO:0019841)
0.1 1.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 1.0 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 1.0 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 1.0 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.2 0.8 GO:0070404 NADH binding(GO:0070404)
0.1 0.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.0 0.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.2 0.6 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.2 0.5 GO:0071723 lipopeptide binding(GO:0071723)
0.1 0.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.4 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 0.4 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.3 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.1 1.0 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.7 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.5 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.3 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER