Motif ID: Ppard

Z-value: 0.618


Transcription factors associated with Ppard:

Gene SymbolEntrez IDGene Name
Ppard ENSMUSG00000002250.9 Ppard

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ppardmm10_v2_chr17_+_28272191_28272205-0.262.9e-01Click!


Activity profile for motif Ppard.

activity profile for motif Ppard


Sorted Z-values histogram for motif Ppard

Sorted Z-values for motif Ppard



Network of associatons between targets according to the STRING database.



First level regulatory network of Ppard

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_+_87948666 5.696 ENSMUST00000005019.5
 Crabp2
cellular retinoic acid binding protein II
chr3_-_8923796 1.171 ENSMUST00000042148.5
 Mrps28
mitochondrial ribosomal protein S28
chr9_-_57262591 1.077 ENSMUST00000034846.5
 1700017B05Rik
RIKEN cDNA 1700017B05 gene
chr4_+_118429701 1.015 ENSMUST00000067896.3
 Elovl1
elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
chr9_-_51278540 0.983 ENSMUST00000114427.3
 Gm684
predicted gene 684
chr4_+_59581563 0.976 ENSMUST00000030078.5
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr11_-_4704334 0.964 ENSMUST00000058407.5
 Uqcr10
ubiquinol-cytochrome c reductase, complex III subunit X
chr5_-_115119277 0.957 ENSMUST00000031524.7
 Acads
acyl-Coenzyme A dehydrogenase, short chain
chr4_+_59581645 0.871 ENSMUST00000107528.1
 Hsdl2
hydroxysteroid dehydrogenase like 2
chr11_+_70657687 0.829 ENSMUST00000134087.1
ENSMUST00000170716.1
 Eno3

enolase 3, beta muscle

chr10_-_13324160 0.814 ENSMUST00000105545.4
 Phactr2
phosphatase and actin regulator 2
chr19_+_37207528 0.790 ENSMUST00000024078.7
ENSMUST00000112391.1
 March5

membrane-associated ring finger (C3HC4) 5

chr17_-_34028044 0.771 ENSMUST00000045467.7
ENSMUST00000114303.3
 H2-Ke6

H2-K region expressed gene 6

chr15_-_89425856 0.757 ENSMUST00000109313.2
 Cpt1b
carnitine palmitoyltransferase 1b, muscle
chr2_-_73911323 0.701 ENSMUST00000111996.1
ENSMUST00000018914.2
 Atp5g3

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)

chr3_-_138131356 0.695 ENSMUST00000029805.8
 Mttp
microsomal triglyceride transfer protein
chr7_+_43444104 0.677 ENSMUST00000004729.3
 Etfb
electron transferring flavoprotein, beta polypeptide
chr8_-_111393810 0.627 ENSMUST00000038475.8
 Fa2h
fatty acid 2-hydroxylase
chr4_+_98546919 0.606 ENSMUST00000030290.7
 Inadl
InaD-like (Drosophila)
chr4_+_118409331 0.602 ENSMUST00000084319.4
ENSMUST00000106384.3
ENSMUST00000126089.1
ENSMUST00000073881.1
ENSMUST00000019229.8
ENSMUST00000144577.1
 Med8





mediator of RNA polymerase II transcription, subunit 8 homolog (yeast)





chr1_-_120120138 0.599 ENSMUST00000112648.1
ENSMUST00000128408.1
 Dbi

diazepam binding inhibitor

chr10_-_93589621 0.573 ENSMUST00000020203.6
 Snrpf
small nuclear ribonucleoprotein polypeptide F
chr4_+_98546710 0.571 ENSMUST00000102792.3
 Inadl
InaD-like (Drosophila)
chr16_-_84835557 0.558 ENSMUST00000138279.1
ENSMUST00000023608.7
 Atp5j

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F

chr10_+_93589413 0.543 ENSMUST00000181835.1
 4933408J17Rik
RIKEN cDNA 4933408J17 gene
chr4_-_45108038 0.538 ENSMUST00000107809.2
ENSMUST00000107808.2
ENSMUST00000107807.1
ENSMUST00000107810.2
 Tomm5



translocase of outer mitochondrial membrane 5 homolog (yeast)



chr13_-_86046901 0.506 ENSMUST00000131011.1
 Cox7c
cytochrome c oxidase subunit VIIc
chr18_-_36726730 0.495 ENSMUST00000061829.6
 Cd14
CD14 antigen
chr2_-_26237368 0.444 ENSMUST00000036187.8
 Qsox2
quiescin Q6 sulfhydryl oxidase 2
chr12_-_40223149 0.423 ENSMUST00000171553.1
ENSMUST00000001672.5
 Ifrd1

interferon-related developmental regulator 1

chr16_-_84835484 0.413 ENSMUST00000114191.1
 Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr5_+_129725063 0.398 ENSMUST00000086046.3
 Gbas
glioblastoma amplified sequence
chr4_-_137048695 0.390 ENSMUST00000049583.7
 Zbtb40
zinc finger and BTB domain containing 40
chr11_-_70015346 0.376 ENSMUST00000018718.7
ENSMUST00000102574.3
 Acadvl

acyl-Coenzyme A dehydrogenase, very long chain

chr4_-_155043143 0.375 ENSMUST00000135665.2
 Plch2
phospholipase C, eta 2
chr5_-_110286159 0.355 ENSMUST00000031472.5
 Pxmp2
peroxisomal membrane protein 2
chr14_+_75136326 0.313 ENSMUST00000145303.1
 Lcp1
lymphocyte cytosolic protein 1
chr5_-_31697598 0.312 ENSMUST00000031018.7
 Rbks
ribokinase
chr5_+_36464998 0.308 ENSMUST00000031099.3
 Grpel1
GrpE-like 1, mitochondrial
chr5_+_110286306 0.303 ENSMUST00000007296.5
ENSMUST00000112482.1
 Pole

polymerase (DNA directed), epsilon

chr3_+_90051630 0.299 ENSMUST00000159064.1
 4933434E20Rik
RIKEN cDNA 4933434E20 gene
chr2_+_75832168 0.299 ENSMUST00000047232.7
ENSMUST00000111952.2
 Agps

alkylglycerone phosphate synthase

chr10_+_94147982 0.291 ENSMUST00000105290.2
 Nr2c1
nuclear receptor subfamily 2, group C, member 1
chr6_+_83156401 0.261 ENSMUST00000032106.4
 1700003E16Rik
RIKEN cDNA 1700003E16 gene
chr1_+_171329376 0.243 ENSMUST00000111299.1
ENSMUST00000064950.4
 Dedd

death effector domain-containing

chr1_+_74506044 0.241 ENSMUST00000087215.5
 Rqcd1
rcd1 (required for cell differentiation) homolog 1 (S. pombe)
chr4_+_131873608 0.225 ENSMUST00000053819.3
 Srsf4
serine/arginine-rich splicing factor 4
chr1_+_55088132 0.212 ENSMUST00000075242.6
 Hspe1
heat shock protein 1 (chaperonin 10)
chr9_-_109059711 0.207 ENSMUST00000061973.4
 Trex1
three prime repair exonuclease 1
chr15_-_50890396 0.196 ENSMUST00000185183.1
 Trps1
trichorhinophalangeal syndrome I (human)
chr16_+_84835070 0.165 ENSMUST00000009120.7
 Gabpa
GA repeat binding protein, alpha
chr9_-_22002599 0.162 ENSMUST00000115336.2
ENSMUST00000044926.5
 Ccdc151

coiled-coil domain containing 151

chr1_-_55088024 0.161 ENSMUST00000027123.8
 Hspd1
heat shock protein 1 (chaperonin)
chr15_-_102189032 0.154 ENSMUST00000023805.1
 Csad
cysteine sulfinic acid decarboxylase
chr18_+_74779190 0.127 ENSMUST00000041053.9
 Acaa2
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
chr15_-_27630644 0.109 ENSMUST00000059662.7
 Fam105b
family with sequence similarity 105, member B
chr6_+_85431970 0.105 ENSMUST00000045693.7
 Smyd5
SET and MYND domain containing 5
chr16_-_23520579 0.099 ENSMUST00000089883.5
 Masp1
mannan-binding lectin serine peptidase 1
chr2_+_92375306 0.096 ENSMUST00000028650.8
 Pex16
peroxisomal biogenesis factor 16
chr2_-_32704123 0.094 ENSMUST00000127812.1
 Fpgs
folylpolyglutamyl synthetase
chr16_-_4624984 0.089 ENSMUST00000014445.6
 Pam16
presequence translocase-asssociated motor 16 homolog (S. cerevisiae)
chr1_+_178319130 0.077 ENSMUST00000027781.6
 Cox20
COX20 Cox2 chaperone
chr9_+_108662098 0.077 ENSMUST00000035222.5
 Slc25a20
solute carrier family 25 (mitochondrial carnitine/acylcarnitine translocase), member 20
chr15_+_25773985 0.075 ENSMUST00000125667.1
 Myo10
myosin X
chr9_+_22003035 0.075 ENSMUST00000115331.2
ENSMUST00000003493.7
 Prkcsh

protein kinase C substrate 80K-H

chr11_+_4986824 0.044 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr16_-_3907651 0.006 ENSMUST00000177221.1
ENSMUST00000177323.1
 1700037C18Rik

RIKEN cDNA 1700037C18 gene

chr10_+_128303322 0.004 ENSMUST00000005825.6
 Pan2
PAN2 polyA specific ribonuclease subunit homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 0.5 GO:0071726 response to diacyl bacterial lipopeptide(GO:0071724) cellular response to diacyl bacterial lipopeptide(GO:0071726)
0.4 5.7 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.1 0.7 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.6 GO:0036151 phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.1 0.8 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 1.0 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.1 0.3 GO:0045004 DNA replication proofreading(GO:0045004)
0.1 1.0 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1 1.0 GO:0034551 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.3 GO:0006014 D-ribose metabolic process(GO:0006014)
0.1 0.6 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.1 0.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 1.7 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.8 GO:0090344 negative regulation of cell aging(GO:0090344)
0.0 0.4 GO:0046322 very long-chain fatty acid catabolic process(GO:0042760) negative regulation of fatty acid oxidation(GO:0046322)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0 0.1 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.0 0.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.4 GO:0048671 negative regulation of collateral sprouting(GO:0048671)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.2 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.2 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 1.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1 0.6 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.1 1.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.1 0.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.5 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.1 0.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.1 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 0.2 GO:0045251 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.7 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.2 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.5 GO:0005779 integral component of peroxisomal membrane(GO:0005779)
0.0 0.3 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.7 GO:0019841 retinol binding(GO:0019841)
0.2 0.6 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.2 0.5 GO:0071723 lipopeptide binding(GO:0071723)
0.2 0.8 GO:0070404 NADH binding(GO:0070404)
0.1 0.4 GO:0017099 very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.1 1.0 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 0.4 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1 0.3 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 1.0 GO:0009922 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1 0.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
0.1 1.0 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.1 0.2 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.7 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.3 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.7 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.5 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.0 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.1 GO:0015226 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.5 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.0 0.5 PID_HNF3A_PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME_MITOCHONDRIAL_FATTY_ACID_BETA_OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.0 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.7 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.6 REACTOME_SLBP_DEPENDENT_PROCESSING_OF_REPLICATION_DEPENDENT_HISTONE_PRE_MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.5 REACTOME_IKK_COMPLEX_RECRUITMENT_MEDIATED_BY_RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.0 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.2 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.3 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0 0.9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.8 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.7 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport