Motif ID: Hoxb5
Z-value: 1.061
Transcription factors associated with Hoxb5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Hoxb5 | ENSMUSG00000038700.3 | Hoxb5 |
Top targets:
Showing 1 to 20 of 92 entries
Gene overrepresentation in biological_process category:
Showing 1 to 20 of 35 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.8 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.2 | 4.2 | GO:0022401 | desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401) |
| 0.2 | 3.4 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.0 | 2.9 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.5 | 2.4 | GO:1903587 | negative regulation of peptidyl-serine dephosphorylation(GO:1902309) regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587) |
| 0.7 | 2.0 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.0 | 2.0 | GO:0018107 | peptidyl-threonine phosphorylation(GO:0018107) |
| 0.4 | 1.9 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.1 | 1.8 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.2 | 1.5 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.1 | 1.4 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 1.3 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.0 | 1.2 | GO:0035725 | sodium ion transmembrane transport(GO:0035725) |
| 0.3 | 1.1 | GO:0006780 | uroporphyrinogen III biosynthetic process(GO:0006780) |
| 0.2 | 1.0 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.0 | 1.0 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.0 | 1.0 | GO:0007271 | synaptic transmission, cholinergic(GO:0007271) |
| 0.2 | 0.9 | GO:0034773 | histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368) |
| 0.0 | 0.9 | GO:0006622 | protein targeting to lysosome(GO:0006622) |
| 0.0 | 0.9 | GO:2000311 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311) |
Gene overrepresentation in cellular_component category:
Showing 1 to 18 of 18 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.5 | 4.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 3.4 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 2.8 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 2.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 2.4 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 2.0 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 1.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.2 | 1.2 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.0 | 1.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 1.1 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 1.0 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.1 | 0.9 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 0.9 | GO:0044754 | autolysosome(GO:0044754) |
| 0.0 | 0.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.7 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.3 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.2 | GO:0033391 | chromatoid body(GO:0033391) |
Gene overrepresentation in molecular_function category:
Showing 1 to 20 of 27 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.7 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 1.4 | 4.2 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 0.0 | 4.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 2.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.6 | 2.8 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.0 | 2.4 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.7 | 2.0 | GO:0019966 | C-X-C chemokine binding(GO:0019958) interleukin-1 binding(GO:0019966) tumor necrosis factor binding(GO:0043120) |
| 0.1 | 2.0 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 1.8 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.5 | 1.5 | GO:0016934 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.1 | 1.4 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
| 0.3 | 1.2 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.2 | 1.1 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.3 | 1.0 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 1.0 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.0 | 0.8 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.8 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.1 | 0.7 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.1 | 0.7 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.0 | 0.7 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
Gene overrepresentation in C2:CP category:
Showing 1 to 8 of 8 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.9 | PID_INTEGRIN5_PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 2.0 | PID_IL6_7_PATHWAY | IL6-mediated signaling events |
| 0.0 | 1.4 | PID_AR_TF_PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.0 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 1.0 | PID_NETRIN_PATHWAY | Netrin-mediated signaling events |
| 0.0 | 0.9 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 0.7 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.7 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
Showing 1 to 12 of 12 entries
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.1 | REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.1 | 2.2 | REACTOME_CGMP_EFFECTS | Genes involved in cGMP effects |
| 0.0 | 2.1 | REACTOME_POTASSIUM_CHANNELS | Genes involved in Potassium Channels |
| 0.2 | 2.0 | REACTOME_INTRINSIC_PATHWAY | Genes involved in Intrinsic Pathway |
| 0.0 | 1.3 | REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 1.2 | REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT | Genes involved in Ligand-gated ion channel transport |
| 0.1 | 1.1 | REACTOME_METABOLISM_OF_PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 1.0 | REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 | Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 |
| 0.0 | 1.0 | REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.0 | 0.9 | REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.0 | 0.4 | REACTOME_P2Y_RECEPTORS | Genes involved in P2Y receptors |
| 0.0 | 0.3 | REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
