Motif ID: Pou2f2_Pou3f1
Z-value: 1.385
Transcription factors associated with Pou2f2_Pou3f1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Pou2f2 | ENSMUSG00000008496.12 | Pou2f2 |
| Pou3f1 | ENSMUSG00000090125.2 | Pou3f1 |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Pou3f1 | mm10_v2_chr4_+_124657646_124657656 | -0.83 | 1.8e-05 | Click! |
| Pou2f2 | mm10_v2_chr7_-_25132473_25132512 | -0.64 | 4.1e-03 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.5 | GO:0060853 | arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101) |
| 1.5 | 5.9 | GO:0021648 | zygotic determination of anterior/posterior axis, embryo(GO:0007354) cranial nerve formation(GO:0021603) vestibulocochlear nerve morphogenesis(GO:0021648) |
| 1.2 | 4.7 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
| 1.1 | 3.3 | GO:0045014 | detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594) |
| 1.0 | 5.1 | GO:0021905 | pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937) |
| 0.9 | 3.6 | GO:0010890 | positive regulation of sequestering of triglyceride(GO:0010890) |
| 0.9 | 3.5 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.9 | 11.1 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.8 | 2.5 | GO:0016332 | establishment or maintenance of polarity of embryonic epithelium(GO:0016332) |
| 0.8 | 2.4 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
| 0.8 | 3.2 | GO:0043973 | histone H3-K4 acetylation(GO:0043973) |
| 0.7 | 2.2 | GO:0060598 | dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis(GO:0060598) |
| 0.6 | 10.5 | GO:0035563 | positive regulation of chromatin binding(GO:0035563) |
| 0.6 | 7.2 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 0.6 | 2.3 | GO:0014846 | esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860) |
| 0.6 | 1.7 | GO:0048023 | positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378) |
| 0.6 | 1.7 | GO:1904059 | regulation of locomotor rhythm(GO:1904059) |
| 0.5 | 1.6 | GO:0009826 | unidimensional cell growth(GO:0009826) susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.5 | 5.4 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.5 | 1.5 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.4 | 1.3 | GO:1904956 | dermatome development(GO:0061054) sclerotome development(GO:0061056) regulation of dermatome development(GO:0061183) regulation of midbrain dopaminergic neuron differentiation(GO:1904956) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041) |
| 0.4 | 1.3 | GO:0001978 | regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) |
| 0.4 | 2.5 | GO:0002326 | B cell lineage commitment(GO:0002326) |
| 0.4 | 0.8 | GO:0021546 | rhombomere development(GO:0021546) |
| 0.4 | 1.1 | GO:0061744 | motor behavior(GO:0061744) |
| 0.4 | 4.3 | GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269) |
| 0.4 | 6.0 | GO:0033234 | negative regulation of protein sumoylation(GO:0033234) |
| 0.3 | 2.2 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.3 | 3.1 | GO:0014807 | regulation of somitogenesis(GO:0014807) |
| 0.3 | 2.0 | GO:0000320 | re-entry into mitotic cell cycle(GO:0000320) |
| 0.3 | 2.1 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.3 | 2.0 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.2 | 1.7 | GO:0035331 | negative regulation of hippo signaling(GO:0035331) |
| 0.2 | 6.8 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.2 | 0.9 | GO:1901252 | regulation of intracellular transport of viral material(GO:1901252) |
| 0.2 | 0.9 | GO:0043490 | malate-aspartate shuttle(GO:0043490) |
| 0.2 | 0.7 | GO:1903644 | regulation of chaperone-mediated protein folding(GO:1903644) |
| 0.2 | 2.3 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.2 | 0.8 | GO:0021502 | neural fold elevation formation(GO:0021502) |
| 0.2 | 0.6 | GO:0044026 | DNA hypermethylation(GO:0044026) hypermethylation of CpG island(GO:0044027) |
| 0.2 | 0.8 | GO:0072272 | proximal/distal pattern formation involved in metanephric nephron development(GO:0072272) |
| 0.2 | 1.7 | GO:0042573 | retinoic acid metabolic process(GO:0042573) |
| 0.2 | 1.3 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.2 | 1.0 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 0.2 | 1.3 | GO:0035093 | spermatogenesis, exchange of chromosomal proteins(GO:0035093) |
| 0.2 | 1.6 | GO:1902166 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166) |
| 0.2 | 18.1 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.2 | 17.8 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.2 | 1.4 | GO:0051152 | positive regulation of smooth muscle cell differentiation(GO:0051152) |
| 0.2 | 0.3 | GO:0000448 | cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000448) |
| 0.2 | 2.0 | GO:2001223 | negative regulation of neuron migration(GO:2001223) |
| 0.1 | 6.6 | GO:0006284 | base-excision repair(GO:0006284) |
| 0.1 | 0.6 | GO:1903998 | regulation of eating behavior(GO:1903998) |
| 0.1 | 6.8 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.1 | 1.1 | GO:0006265 | DNA topological change(GO:0006265) |
| 0.1 | 0.8 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.1 | 0.8 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.1 | 0.5 | GO:0070269 | pyroptosis(GO:0070269) |
| 0.1 | 0.7 | GO:2000138 | positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138) |
| 0.1 | 0.3 | GO:0046909 | intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445) |
| 0.1 | 2.1 | GO:0097237 | cellular response to toxic substance(GO:0097237) |
| 0.1 | 0.4 | GO:0031660 | regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) positive regulation of calcium-transporting ATPase activity(GO:1901896) |
| 0.1 | 0.4 | GO:1904170 | regulation of bleb assembly(GO:1904170) |
| 0.1 | 0.5 | GO:1903715 | regulation of aerobic respiration(GO:1903715) |
| 0.1 | 1.5 | GO:0002082 | regulation of oxidative phosphorylation(GO:0002082) |
| 0.1 | 1.0 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.1 | 2.1 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.1 | 0.5 | GO:2000255 | negative regulation of male germ cell proliferation(GO:2000255) |
| 0.1 | 1.4 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.1 | 0.4 | GO:0046898 | response to cycloheximide(GO:0046898) |
| 0.1 | 0.4 | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development(GO:0060800) |
| 0.1 | 0.7 | GO:0070236 | negative regulation of activation-induced cell death of T cells(GO:0070236) |
| 0.1 | 0.8 | GO:0090209 | negative regulation of triglyceride metabolic process(GO:0090209) |
| 0.1 | 0.4 | GO:0070166 | enamel mineralization(GO:0070166) |
| 0.1 | 1.0 | GO:0045199 | maintenance of epithelial cell apical/basal polarity(GO:0045199) |
| 0.1 | 0.5 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
| 0.1 | 2.0 | GO:0030513 | positive regulation of BMP signaling pathway(GO:0030513) |
| 0.1 | 0.2 | GO:2000054 | regulation of chondrocyte development(GO:0061181) regulation of centromeric sister chromatid cohesion(GO:0070602) regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054) |
| 0.1 | 0.7 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 0.1 | 1.5 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 2.1 | GO:0043171 | peptide catabolic process(GO:0043171) |
| 0.1 | 0.2 | GO:0002322 | B cell proliferation involved in immune response(GO:0002322) |
| 0.1 | 1.6 | GO:0010569 | regulation of double-strand break repair via homologous recombination(GO:0010569) |
| 0.1 | 0.5 | GO:0060736 | prostate gland growth(GO:0060736) |
| 0.1 | 0.2 | GO:1902202 | regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) |
| 0.1 | 1.1 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.1 | 0.4 | GO:1904217 | regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222) |
| 0.1 | 0.2 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.1 | 1.9 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.0 | 1.1 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.0 | 0.3 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 0.2 | GO:0071600 | otic vesicle morphogenesis(GO:0071600) |
| 0.0 | 0.4 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
| 0.0 | 0.8 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.1 | GO:0006553 | lysine metabolic process(GO:0006553) |
| 0.0 | 0.5 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.0 | 1.2 | GO:0043029 | T cell homeostasis(GO:0043029) |
| 0.0 | 2.4 | GO:0021510 | spinal cord development(GO:0021510) |
| 0.0 | 1.8 | GO:0002066 | columnar/cuboidal epithelial cell development(GO:0002066) |
| 0.0 | 1.1 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
| 0.0 | 1.1 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
| 0.0 | 0.8 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 0.7 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.0 | 1.3 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 2.4 | GO:0007098 | centrosome cycle(GO:0007098) |
| 0.0 | 1.0 | GO:1900046 | regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046) |
| 0.0 | 0.4 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
| 0.0 | 0.3 | GO:0002115 | store-operated calcium entry(GO:0002115) |
| 0.0 | 0.5 | GO:0071300 | cellular response to retinoic acid(GO:0071300) |
| 0.0 | 0.3 | GO:0000413 | protein peptidyl-prolyl isomerization(GO:0000413) |
| 0.0 | 0.2 | GO:0043403 | skeletal muscle tissue regeneration(GO:0043403) |
| 0.0 | 2.4 | GO:0019221 | cytokine-mediated signaling pathway(GO:0019221) |
| 0.0 | 0.2 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 6.0 | GO:0002111 | BRCA2-BRAF35 complex(GO:0002111) |
| 0.9 | 6.6 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.7 | 2.2 | GO:0043540 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540) |
| 0.5 | 3.6 | GO:0042627 | chylomicron(GO:0042627) |
| 0.4 | 2.4 | GO:0001674 | female germ cell nucleus(GO:0001674) |
| 0.4 | 26.6 | GO:0000786 | nucleosome(GO:0000786) |
| 0.3 | 1.7 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.3 | 1.5 | GO:0002193 | MAML1-RBP-Jkappa- ICN1 complex(GO:0002193) |
| 0.3 | 1.1 | GO:0001651 | dense fibrillar component(GO:0001651) |
| 0.2 | 3.0 | GO:0043196 | varicosity(GO:0043196) |
| 0.2 | 1.5 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.2 | 3.3 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.2 | 1.1 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.2 | 2.0 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 0.5 | GO:0061702 | inflammasome complex(GO:0061702) |
| 0.1 | 1.5 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 0.5 | GO:0008623 | CHRAC(GO:0008623) |
| 0.1 | 0.4 | GO:0036128 | CatSper complex(GO:0036128) |
| 0.1 | 1.4 | GO:0000940 | condensed chromosome outer kinetochore(GO:0000940) |
| 0.1 | 0.4 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 1.7 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.1 | 0.9 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.1 | 0.2 | GO:0048269 | methionine adenosyltransferase complex(GO:0048269) |
| 0.1 | 0.8 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 5.8 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 18.7 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 3.1 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.4 | GO:0097136 | Bcl-2 family protein complex(GO:0097136) |
| 0.0 | 2.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 2.0 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 9.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 1.7 | GO:0000794 | condensed nuclear chromosome(GO:0000794) |
| 0.0 | 3.3 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.6 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 2.9 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 1.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.0 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 4.6 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 3.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 1.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 1.4 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 3.9 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 2.5 | GO:0045121 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 6.1 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
| 0.7 | 11.7 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.7 | 3.5 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
| 0.5 | 3.7 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.5 | 2.3 | GO:0008449 | N-acetylglucosamine-6-sulfatase activity(GO:0008449) |
| 0.4 | 2.5 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.4 | 3.2 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.3 | 2.0 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.3 | 2.2 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.3 | 1.4 | GO:0043515 | kinetochore binding(GO:0043515) |
| 0.3 | 1.1 | GO:0097100 | supercoiled DNA binding(GO:0097100) |
| 0.3 | 3.1 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.2 | 0.9 | GO:0015183 | L-aspartate transmembrane transporter activity(GO:0015183) |
| 0.2 | 3.4 | GO:0030957 | Tat protein binding(GO:0030957) |
| 0.2 | 2.4 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.2 | 0.7 | GO:0043426 | MRF binding(GO:0043426) |
| 0.2 | 0.5 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
| 0.2 | 3.1 | GO:0071837 | HMG box domain binding(GO:0071837) |
| 0.2 | 1.1 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.2 | 2.1 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 1.3 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.1 | 3.4 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 0.1 | 0.5 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.1 | 6.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.1 | 2.0 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 1.5 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
| 0.1 | 1.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 1.7 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.1 | 3.4 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 6.8 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 1.6 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.1 | 0.6 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 0.1 | 1.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 2.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 2.1 | GO:0070006 | metalloaminopeptidase activity(GO:0070006) |
| 0.1 | 1.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 1.3 | GO:0019825 | oxygen binding(GO:0019825) |
| 0.1 | 18.0 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.1 | 0.8 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 4.8 | GO:0001158 | enhancer sequence-specific DNA binding(GO:0001158) |
| 0.1 | 0.9 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.5 | GO:1901612 | phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612) |
| 0.1 | 0.6 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.1 | 0.2 | GO:0005171 | hepatocyte growth factor receptor binding(GO:0005171) |
| 0.1 | 2.4 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 0.7 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.1 | 0.9 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
| 0.0 | 0.8 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.4 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.0 | 0.3 | GO:0051731 | polynucleotide 5'-hydroxyl-kinase activity(GO:0051731) |
| 0.0 | 0.7 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 0.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 1.1 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 0.4 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.0 | 10.2 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.0 | 0.2 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 13.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.0 | 0.8 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.1 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 0.0 | 1.3 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.6 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.0 | 0.4 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.3 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 1.0 | GO:0020037 | heme binding(GO:0020037) |
| 0.0 | 1.3 | GO:0002039 | p53 binding(GO:0002039) |
| 0.0 | 3.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.7 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 1.7 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 2.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.3 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.3 | GO:0051959 | dynein light intermediate chain binding(GO:0051959) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 11.1 | PID_P38_MKK3_6PATHWAY | p38 MAPK signaling pathway |
| 0.2 | 6.5 | PID_RAS_PATHWAY | Regulation of Ras family activation |
| 0.2 | 3.4 | PID_IL27_PATHWAY | IL27-mediated signaling events |
| 0.1 | 2.0 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 7.4 | PID_IL4_2PATHWAY | IL4-mediated signaling events |
| 0.1 | 4.8 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 4.0 | NABA_COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 4.9 | PID_PS1_PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 2.5 | PID_FOXM1_PATHWAY | FOXM1 transcription factor network |
| 0.1 | 5.7 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.3 | PID_HES_HEY_PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 0.7 | PID_IL3_PATHWAY | IL3-mediated signaling events |
| 0.0 | 2.2 | PID_TAP63_PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 3.3 | PID_CDC42_PATHWAY | CDC42 signaling events |
| 0.0 | 0.5 | PID_IL2_STAT5_PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 1.1 | PID_CASPASE_PATHWAY | Caspase cascade in apoptosis |
| 0.0 | 0.6 | PID_AURORA_B_PATHWAY | Aurora B signaling |
| 0.0 | 0.5 | PID_ERBB4_PATHWAY | ErbB4 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 33.2 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.8 | 6.6 | REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.4 | 1.8 | REACTOME_ETHANOL_OXIDATION | Genes involved in Ethanol oxidation |
| 0.4 | 6.8 | REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.4 | 5.1 | REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.3 | 3.6 | REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 3.4 | REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR | Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor |
| 0.2 | 2.1 | REACTOME_CRMPS_IN_SEMA3A_SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.2 | 4.3 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 5.8 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 3.1 | REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.1 | 2.9 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 1.3 | REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.1 | REACTOME_GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 1.2 | REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.1 | 4.0 | REACTOME_COLLAGEN_FORMATION | Genes involved in Collagen formation |
| 0.1 | 1.3 | REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 1.9 | REACTOME_MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 0.3 | REACTOME_ELEVATION_OF_CYTOSOLIC_CA2_LEVELS | Genes involved in Elevation of cytosolic Ca2+ levels |
| 0.0 | 0.4 | REACTOME_INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 2.6 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.5 | REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.1 | REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 0.4 | REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.0 | 0.4 | REACTOME_MEIOTIC_SYNAPSIS | Genes involved in Meiotic Synapsis |
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