Motif ID: Pou2f2_Pou3f1

Z-value: 1.385

Transcription factors associated with Pou2f2_Pou3f1:

Gene SymbolEntrez IDGene Name
Pou2f2 ENSMUSG00000008496.12 Pou2f2
Pou3f1 ENSMUSG00000090125.2 Pou3f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou3f1mm10_v2_chr4_+_124657646_124657656-0.831.8e-05Click!
Pou2f2mm10_v2_chr7_-_25132473_25132512-0.644.1e-03Click!


Activity profile for motif Pou2f2_Pou3f1.

activity profile for motif Pou2f2_Pou3f1


Sorted Z-values histogram for motif Pou2f2_Pou3f1

Sorted Z-values for motif Pou2f2_Pou3f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou2f2_Pou3f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_+_67234620 10.547 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr6_-_67037399 9.056 ENSMUST00000043098.6
 Gadd45a
growth arrest and DNA-damage-inducible 45 alpha
chr7_+_45017953 6.765 ENSMUST00000044111.7
 Rras
Harvey rat sarcoma oncogene, subgroup R
chr13_-_56252163 5.854 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr7_+_24507122 5.368 ENSMUST00000177205.1
 Zfp428
zinc finger protein 428
chr17_-_58991343 5.292 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr7_+_24507057 4.949 ENSMUST00000071361.6
 Zfp428
zinc finger protein 428
chr13_+_23746734 4.865 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr14_-_48662740 4.734 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr13_+_21722057 4.664 ENSMUST00000110476.3
 Hist1h2bm
histone cluster 1, H2bm
chr7_+_24507006 4.344 ENSMUST00000176880.1
 Zfp428
zinc finger protein 428
chr8_-_90908415 3.856 ENSMUST00000098517.1
 Gm6658
predicted gene 6658
chr3_+_96269695 3.822 ENSMUST00000051089.3
ENSMUST00000177113.1
 Hist2h2bb

histone cluster 2, H2bb

chr11_+_95337012 3.773 ENSMUST00000037502.6
 Fam117a
family with sequence similarity 117, member A
chr9_+_74848437 3.743 ENSMUST00000161862.1
ENSMUST00000162089.1
ENSMUST00000160017.1
ENSMUST00000160950.1
 Gm16551


Gm20649
predicted gene 16551


predicted gene 20649
chr7_-_102100227 3.726 ENSMUST00000106937.1
 Art5
ADP-ribosyltransferase 5
chr8_+_68880491 3.600 ENSMUST00000015712.8
 Lpl
lipoprotein lipase
chr7_+_24507099 3.494 ENSMUST00000177228.1
 Zfp428
zinc finger protein 428
chr17_-_15375969 3.437 ENSMUST00000014917.7
 Dll1
delta-like 1 (Drosophila)
chr1_+_52008210 3.360 ENSMUST00000027277.5
 Stat4
signal transducer and activator of transcription 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 113 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 18.1 GO:0006334 nucleosome assembly(GO:0006334)
0.2 17.8 GO:0006342 chromatin silencing(GO:0006342)
0.9 11.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.6 10.5 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.6 7.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 6.8 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.1 6.8 GO:0060325 face morphogenesis(GO:0060325)
0.1 6.6 GO:0006284 base-excision repair(GO:0006284)
0.4 6.0 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
1.5 5.9 GO:0021648 zygotic determination of anterior/posterior axis, embryo(GO:0007354) cranial nerve formation(GO:0021603) vestibulocochlear nerve morphogenesis(GO:0021648)
0.5 5.4 GO:0048664 neuron fate determination(GO:0048664)
1.0 5.1 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.2 4.7 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.5 4.5 GO:0060853 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.4 4.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.9 3.6 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.9 3.5 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
1.1 3.3 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
0.8 3.2 GO:0043973 histone H3-K4 acetylation(GO:0043973)
0.3 3.1 GO:0014807 regulation of somitogenesis(GO:0014807)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 26.6 GO:0000786 nucleosome(GO:0000786)
0.0 18.7 GO:0000790 nuclear chromatin(GO:0000790)
0.0 9.6 GO:0016607 nuclear speck(GO:0016607)
0.9 6.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
1.5 6.0 GO:0002111 BRCA2-BRAF35 complex(GO:0002111)
0.1 5.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 4.6 GO:0016324 apical plasma membrane(GO:0016324)
0.0 3.9 GO:0043025 neuronal cell body(GO:0043025)
0.5 3.6 GO:0042627 chylomicron(GO:0042627)
0.2 3.3 GO:0035102 PRC1 complex(GO:0035102)
0.0 3.3 GO:0030426 growth cone(GO:0030426)
0.0 3.1 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 3.0 GO:0043196 varicosity(GO:0043196)
0.0 3.0 GO:0043209 myelin sheath(GO:0043209)
0.0 2.9 GO:0030496 midbody(GO:0030496)
0.0 2.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 2.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.4 2.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.7 2.2 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.2 2.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 71 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 18.0 GO:0001047 core promoter binding(GO:0001047)
0.0 13.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.7 11.7 GO:0003680 AT DNA binding(GO:0003680)
0.0 10.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 6.8 GO:0019003 GDP binding(GO:0019003)
0.1 6.3 GO:0070888 E-box binding(GO:0070888)
2.0 6.1 GO:0003953 NAD+ nucleosidase activity(GO:0003953)
0.1 4.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.5 3.7 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.7 3.5 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.2 3.4 GO:0030957 Tat protein binding(GO:0030957)
0.1 3.4 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 3.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 3.3 GO:0051015 actin filament binding(GO:0051015)
0.4 3.2 GO:0030274 LIM domain binding(GO:0030274)
0.3 3.1 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 3.1 GO:0071837 HMG box domain binding(GO:0071837)
0.4 2.5 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 2.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 2.4 GO:0016500 protein-hormone receptor activity(GO:0016500)

Gene overrepresentation in C2:CP category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 11.1 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.1 7.4 PID_IL4_2PATHWAY IL4-mediated signaling events
0.2 6.5 PID_RAS_PATHWAY Regulation of Ras family activation
0.1 5.7 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.9 PID_PS1_PATHWAY Presenilin action in Notch and Wnt signaling
0.1 4.8 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 4.0 NABA_COLLAGENS Genes encoding collagen proteins
0.2 3.4 PID_IL27_PATHWAY IL27-mediated signaling events
0.0 3.3 PID_CDC42_PATHWAY CDC42 signaling events
0.1 2.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 2.3 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.0 2.2 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.0 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.1 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.7 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.6 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.5 PID_IL2_STAT5_PATHWAY IL2 signaling events mediated by STAT5
0.0 0.5 PID_ERBB4_PATHWAY ErbB4 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 33.2 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.4 6.8 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.8 6.6 REACTOME_APOBEC3G_MEDIATED_RESISTANCE_TO_HIV1_INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.2 5.8 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 5.1 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 4.3 REACTOME_AMYLOIDS Genes involved in Amyloids
0.1 4.0 REACTOME_COLLAGEN_FORMATION Genes involved in Collagen formation
0.3 3.6 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 3.4 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 3.1 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 3.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 2.1 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.9 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.4 1.8 REACTOME_ETHANOL_OXIDATION Genes involved in Ethanol oxidation
0.1 1.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.2 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.1 REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2_ Genes involved in Response to elevated platelet cytosolic Ca2+