Motif ID: Sox21

Z-value: 0.513


Transcription factors associated with Sox21:

Gene SymbolEntrez IDGene Name
Sox21 ENSMUSG00000061517.7 Sox21

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox21mm10_v2_chr14_-_118237016_1182370350.272.8e-01Click!


Activity profile for motif Sox21.

activity profile for motif Sox21


Sorted Z-values histogram for motif Sox21

Sorted Z-values for motif Sox21



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox21

PNG image of the network

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Top targets:


Showing 1 to 20 of 111 entries
PromoterScoreRefseqGene SymbolGene Name
chrM_-_14060 1.770 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr19_+_44493472 1.417 ENSMUST00000041163.4
 Wnt8b
wingless related MMTV integration site 8b
chr1_+_107511416 1.197 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_109993982 1.056 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr17_-_70998010 0.796 ENSMUST00000024846.6
 Myl12a
myosin, light chain 12A, regulatory, non-sarcomeric
chr10_+_56377300 0.742 ENSMUST00000068581.7
 Gja1
gap junction protein, alpha 1
chr19_+_7557473 0.655 ENSMUST00000141887.1
ENSMUST00000136756.1
 Pla2g16

phospholipase A2, group XVI

chr5_-_87490869 0.554 ENSMUST00000147854.1
 Ugt2a1
UDP glucuronosyltransferase 2 family, polypeptide A1
chr1_+_171113918 0.531 ENSMUST00000129651.1
ENSMUST00000151340.1
 1700009P17Rik

RIKEN cDNA 1700009P17 gene

chr8_-_111393810 0.523 ENSMUST00000038475.8
 Fa2h
fatty acid 2-hydroxylase
chr8_-_107439585 0.504 ENSMUST00000077208.4
 Rps26-ps1
ribosomal protein S26, pseudogene 1
chrM_+_11734 0.490 ENSMUST00000082418.1
 mt-Nd5
mitochondrially encoded NADH dehydrogenase 5
chr8_-_57652993 0.479 ENSMUST00000110316.2
 Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr3_-_10208569 0.472 ENSMUST00000029041.4
 Fabp4
fatty acid binding protein 4, adipocyte
chr16_-_59632520 0.466 ENSMUST00000118438.1
 Arl6
ADP-ribosylation factor-like 6
chr17_-_26099257 0.464 ENSMUST00000053575.3
 Gm8186
predicted gene 8186
chr15_+_31602106 0.453 ENSMUST00000042702.6
 Fam173b
family with sequence similarity 173, member B
chr6_+_120666388 0.433 ENSMUST00000112686.1
 Cecr2
cat eye syndrome chromosome region, candidate 2
chr2_-_72986716 0.429 ENSMUST00000112062.1
 Gm11084
predicted gene 11084
chr3_-_33082004 0.419 ENSMUST00000108225.3
 Pex5l
peroxisomal biogenesis factor 5-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:1904177 regulation of adipose tissue development(GO:1904177)
0.0 1.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.3 1.0 GO:0003347 epicardial cell to mesenchymal cell transition(GO:0003347)
0.1 0.6 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.6 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 0.5 GO:0046909 intermembrane transport(GO:0046909) protein transport from ciliary membrane to plasma membrane(GO:1903445)
0.1 0.5 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.5 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.5 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391) cGMP catabolic process(GO:0046069)
0.1 0.4 GO:0009814 defense response, incompatible interaction(GO:0009814)
0.1 0.4 GO:0044830 modulation by host of viral RNA genome replication(GO:0044830)
0.1 0.4 GO:0033762 response to glucagon(GO:0033762)
0.1 0.4 GO:0051461 regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.0 0.4 GO:0001842 neural fold formation(GO:0001842)
0.0 0.4 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.4 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.4 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291)
0.1 0.3 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 0.3 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.1 0.3 GO:0007412 axon target recognition(GO:0007412)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 GO:0070469 respiratory chain(GO:0070469)
0.0 0.8 GO:0016460 myosin II complex(GO:0016460)
0.1 0.7 GO:0005916 fascia adherens(GO:0005916)
0.1 0.4 GO:0090537 CERF complex(GO:0090537)
0.1 0.4 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 0.4 GO:0044305 calyx of Held(GO:0044305)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.1 0.3 GO:0060187 cell pole(GO:0060187)
0.0 0.3 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.2 GO:0042629 mast cell granule(GO:0042629)
0.0 0.2 GO:0032797 SMN complex(GO:0032797)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.6 GO:0005109 frizzled binding(GO:0005109)
0.0 1.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.4 1.1 GO:0052740 phosphatidylserine 1-acylhydrolase activity(GO:0052739) 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.2 0.7 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 0.5 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.5 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.5 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.4 GO:0001565 phorbol ester receptor activity(GO:0001565) non-kinase phorbol ester receptor activity(GO:0001566)
0.1 0.4 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.0 0.4 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.1 0.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.3 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 0.2 GO:0071568 UFM1 transferase activity(GO:0071568)
0.0 0.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.8 REACTOME_ACYL_CHAIN_REMODELLING_OF_PI Genes involved in Acyl chain remodelling of PI
0.1 0.7 REACTOME_GAP_JUNCTION_ASSEMBLY Genes involved in Gap junction assembly
0.1 0.6 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.5 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 0.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.0 0.4 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.1 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR Genes involved in Trafficking and processing of endosomal TLR