Motif ID: Hoxb7

Z-value: 4.531


Transcription factors associated with Hoxb7:

Gene SymbolEntrez IDGene Name
Hoxb7 ENSMUSG00000038721.8 Hoxb7



Activity profile for motif Hoxb7.

activity profile for motif Hoxb7


Sorted Z-values histogram for motif Hoxb7

Sorted Z-values for motif Hoxb7



Network of associatons between targets according to the STRING database.



First level regulatory network of Hoxb7

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_83504032 35.830 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr4_+_102589687 27.593 ENSMUST00000097949.4
ENSMUST00000106901.1
 Pde4b

phosphodiesterase 4B, cAMP specific

chr2_+_71528657 23.096 ENSMUST00000126400.1
 Dlx1
distal-less homeobox 1
chr16_+_42907563 22.493 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr5_+_117841839 20.965 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr1_+_19103022 20.657 ENSMUST00000037294.7
 Tfap2d
transcription factor AP-2, delta
chr15_+_21111452 19.140 ENSMUST00000075132.6
 Cdh12
cadherin 12
chr1_-_56969827 19.072 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969864 18.618 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr6_-_136171722 18.409 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr16_+_43247278 17.716 ENSMUST00000114691.1
ENSMUST00000079441.6
 Zbtb20

zinc finger and BTB domain containing 20

chr17_-_81649607 17.373 ENSMUST00000163680.2
ENSMUST00000086538.3
ENSMUST00000163123.1
 Slc8a1


solute carrier family 8 (sodium/calcium exchanger), member 1


chr19_-_28911879 16.445 ENSMUST00000179171.1
 AC163993.1
AC163993.1
chr6_-_13839916 16.433 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr2_+_65930117 15.453 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr9_-_40346290 15.263 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr8_+_54954728 15.240 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr2_-_7396192 15.121 ENSMUST00000137733.2
 Celf2
CUGBP, Elav-like family member 2
chr7_+_91090697 15.034 ENSMUST00000107196.2
 Dlg2
discs, large homolog 2 (Drosophila)
chr12_+_29528382 14.980 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 430 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.1 86.2 GO:0006376 mRNA splice site selection(GO:0006376)
4.8 62.1 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.4 60.1 GO:0031032 actomyosin structure organization(GO:0031032)
1.4 58.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
5.7 51.3 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
14.3 43.0 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
3.6 40.1 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.9 37.2 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
2.5 35.6 GO:0045161 neuronal ion channel clustering(GO:0045161)
2.1 34.2 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.3 33.2 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
5.3 31.8 GO:1903056 positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
10.1 30.3 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923)
2.3 28.2 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
2.2 28.0 GO:0070842 aggresome assembly(GO:0070842)
3.3 26.5 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
2.9 26.5 GO:0098907 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
8.6 25.8 GO:0061075 cerebral cortex GABAergic interneuron fate commitment(GO:0021893) positive regulation of neural retina development(GO:0061075) positive regulation of retina development in camera-type eye(GO:1902868) positive regulation of amacrine cell differentiation(GO:1902871)
0.4 23.9 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 23.7 GO:0034605 cellular response to heat(GO:0034605)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 159.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 101.9 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
1.9 78.6 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.6 58.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.4 51.4 GO:0031225 anchored component of membrane(GO:0031225)
2.7 51.3 GO:0071564 npBAF complex(GO:0071564)
2.2 44.5 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.3 41.3 GO:0030017 sarcomere(GO:0030017)
0.2 36.4 GO:0098794 postsynapse(GO:0098794)
1.7 33.5 GO:0044224 juxtaparanode region of axon(GO:0044224)
2.2 32.4 GO:0043083 synaptic cleft(GO:0043083)
3.2 29.2 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
1.4 28.9 GO:0031430 M band(GO:0031430)
1.8 26.8 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.3 26.7 GO:0042641 actomyosin(GO:0042641)
2.9 26.5 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 25.6 GO:0045202 synapse(GO:0045202)
1.7 22.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
1.9 21.0 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
1.2 20.8 GO:0031045 dense core granule(GO:0031045)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 275 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 87.9 GO:0036002 pre-mRNA binding(GO:0036002)
1.2 71.4 GO:0030507 spectrin binding(GO:0030507)
1.8 60.5 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.2 58.1 GO:0008017 microtubule binding(GO:0008017)
0.3 56.5 GO:0004386 helicase activity(GO:0004386)
1.4 41.6 GO:0008157 protein phosphatase 1 binding(GO:0008157)
2.3 36.5 GO:0003680 AT DNA binding(GO:0003680)
5.7 34.0 GO:0070699 type II activin receptor binding(GO:0070699)
1.4 33.5 GO:0004385 guanylate kinase activity(GO:0004385)
1.3 33.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
3.8 30.3 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
1.0 30.1 GO:0070412 R-SMAD binding(GO:0070412)
0.3 29.9 GO:0005057 receptor signaling protein activity(GO:0005057)
0.9 28.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 27.4 GO:0005096 GTPase activator activity(GO:0005096)
0.5 26.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 25.6 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
3.2 25.4 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.4 23.4 GO:0005262 calcium channel activity(GO:0005262)
2.2 22.1 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 70 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 81.2 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
1.0 43.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.9 31.1 PID_IL3_PATHWAY IL3-mediated signaling events
0.8 29.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.4 24.3 PID_LKB1_PATHWAY LKB1 signaling events
0.4 21.8 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.5 19.9 PID_LIS1_PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.5 19.4 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.4 18.9 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.5 17.9 PID_ALK1_PATHWAY ALK1 signaling events
0.5 16.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 16.4 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.3 15.1 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 15.1 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 14.9 PID_TGFBR_PATHWAY TGF-beta receptor signaling
0.3 14.9 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.4 12.7 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.3 11.1 PID_FGF_PATHWAY FGF signaling pathway
0.3 10.8 PID_TNF_PATHWAY TNF receptor signaling pathway
0.3 9.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 97 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 84.0 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
2.0 71.9 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.7 46.6 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.6 45.3 REACTOME_L1CAM_INTERACTIONS Genes involved in L1CAM interactions
1.4 37.6 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.4 35.2 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
2.5 25.4 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.6 24.6 REACTOME_RNA_POL_III_TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
1.2 22.9 REACTOME_LIGAND_GATED_ION_CHANNEL_TRANSPORT Genes involved in Ligand-gated ion channel transport
0.8 21.4 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.3 21.3 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
1.5 18.9 REACTOME_PLATELET_CALCIUM_HOMEOSTASIS Genes involved in Platelet calcium homeostasis
4.0 16.2 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.6 16.0 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.7 12.9 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 11.2 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 10.6 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.7 9.0 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.6 8.4 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.6 8.1 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors