Motif ID: Isl2

Z-value: 0.641


Transcription factors associated with Isl2:

Gene SymbolEntrez IDGene Name
Isl2 ENSMUSG00000032318.6 Isl2



Activity profile for motif Isl2.

activity profile for motif Isl2


Sorted Z-values histogram for motif Isl2

Sorted Z-values for motif Isl2



Network of associatons between targets according to the STRING database.



First level regulatory network of Isl2

PNG image of the network

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Top targets:


Showing 1 to 20 of 160 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_48432723 2.130 ENSMUST00000046549.3
Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr1_+_12718496 2.122 ENSMUST00000088585.3
Sulf1
sulfatase 1
chr10_-_77166545 1.769 ENSMUST00000081654.6
Col18a1
collagen, type XVIII, alpha 1
chrX_-_60893430 1.639 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr1_-_163289214 1.319 ENSMUST00000183691.1
Prrx1
paired related homeobox 1
chr12_-_10900296 1.171 ENSMUST00000085735.2
Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr3_-_79841729 1.153 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chrX_+_136245065 1.103 ENSMUST00000048687.4
Wbp5
WW domain binding protein 5
chr9_-_100506844 1.086 ENSMUST00000112874.3
Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr4_+_3940747 1.047 ENSMUST00000119403.1
Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr17_+_17402672 1.014 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chrX_+_96455359 1.007 ENSMUST00000033553.7
Heph
hephaestin
chr7_+_100159241 0.988 ENSMUST00000032967.3
Lipt2
lipoyl(octanoyl) transferase 2 (putative)
chr8_-_61902669 0.978 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr13_-_58354862 0.953 ENSMUST00000043605.5
Kif27
kinesin family member 27
chr17_+_20570362 0.921 ENSMUST00000095633.3
Gm5145
predicted pseudogene 5145
chrM_+_8600 0.907 ENSMUST00000082409.1
mt-Co3
mitochondrially encoded cytochrome c oxidase III
chrM_+_9452 0.888 ENSMUST00000082411.1
mt-Nd3
mitochondrially encoded NADH dehydrogenase 3
chr1_+_110099295 0.840 ENSMUST00000134301.1
Cdh7
cadherin 7, type 2
chr3_-_33082004 0.837 ENSMUST00000108225.3
Pex5l
peroxisomal biogenesis factor 5-like

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 56 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.5 2.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.1 1.9 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 1.6 GO:0007530 sex determination(GO:0007530)
0.5 1.5 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) acetyl-CoA catabolic process(GO:0046356)
0.1 1.3 GO:0048664 neuron fate determination(GO:0048664)
0.0 1.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.4 1.1 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 1.1 GO:0003351 epithelial cilium movement(GO:0003351)
0.3 1.0 GO:0009106 lipoate metabolic process(GO:0009106)
0.1 1.0 GO:0003334 keratinocyte development(GO:0003334)
0.1 1.0 GO:0006825 copper ion transport(GO:0006825)
0.0 1.0 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.0 GO:0097352 autophagosome maturation(GO:0097352)
0.1 0.9 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.0 0.9 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.8 GO:0051461 protein import into peroxisome matrix, docking(GO:0016560) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 0.8 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.2 0.7 GO:0036292 DNA rewinding(GO:0036292)
0.2 0.7 GO:0072592 regulation of integrin biosynthetic process(GO:0045113) oxygen metabolic process(GO:0072592)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 2.3 GO:0070469 respiratory chain(GO:0070469)
0.0 1.8 GO:0005581 collagen trimer(GO:0005581)
0.1 1.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 1.0 GO:0002102 podosome(GO:0002102)
0.0 1.0 GO:0005871 kinesin complex(GO:0005871)
0.2 0.8 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.2 0.7 GO:0071438 invadopodium membrane(GO:0071438)
0.2 0.6 GO:0060187 cell pole(GO:0060187)
0.1 0.6 GO:0001740 Barr body(GO:0001740)
0.1 0.5 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.5 GO:0000974 Prp19 complex(GO:0000974)
0.0 0.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 0.5 GO:0043596 nuclear replication fork(GO:0043596)
0.1 0.4 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.3 GO:0061617 MICOS complex(GO:0061617)
0.0 0.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 0.2 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.4 2.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 1.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.6 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 1.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.5 1.5 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 1.3 GO:0071837 HMG box domain binding(GO:0071837)
0.2 1.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.2 1.0 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 1.0 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.9 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.3 0.8 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.2 0.8 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.2 0.7 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.2 0.7 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 0.7 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0 0.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.5 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)

Gene overrepresentation in C2:CP category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.8 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 1.2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.1 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.8 PID_FGF_PATHWAY FGF signaling pathway
0.0 0.4 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.2 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.2 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.1 1.1 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 1.0 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 0.8 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 0.7 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.7 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.6 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 0.5 REACTOME_THE_ACTIVATION_OF_ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.1 0.5 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.5 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME_SYNTHESIS_OF_PA Genes involved in Synthesis of PA
0.0 0.4 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 0.3 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.3 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.3 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.2 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha