Motif ID: E2f3

Z-value: 0.864


Transcription factors associated with E2f3:

Gene SymbolEntrez IDGene Name
E2f3 ENSMUSG00000016477.11 E2f3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f3mm10_v2_chr13_-_29984219_299843530.494.1e-02Click!


Activity profile for motif E2f3.

activity profile for motif E2f3


Sorted Z-values histogram for motif E2f3

Sorted Z-values for motif E2f3



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_+_46450892 2.294 ENSMUST00000102926.4
 Anp32b
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr7_-_137314394 1.966 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr5_+_114568016 1.524 ENSMUST00000043650.7
 Fam222a
family with sequence similarity 222, member A
chrX_-_51205773 1.230 ENSMUST00000114875.1
 Mbnl3
muscleblind-like 3 (Drosophila)
chr11_-_100759942 1.212 ENSMUST00000107363.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr1_+_187609028 1.065 ENSMUST00000110939.1
 Esrrg
estrogen-related receptor gamma
chr7_+_13278778 1.045 ENSMUST00000098814.4
ENSMUST00000146998.1
ENSMUST00000185145.1
 Lig1


ligase I, DNA, ATP-dependent


chr17_+_35841668 0.985 ENSMUST00000174124.1
 Mdc1
mediator of DNA damage checkpoint 1
chr15_-_79605084 0.972 ENSMUST00000023065.6
 Dmc1
DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination
chr19_+_41482632 0.875 ENSMUST00000067795.5
 Lcor
ligand dependent nuclear receptor corepressor
chr12_-_69228167 0.875 ENSMUST00000021359.5
 Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr18_+_11657349 0.817 ENSMUST00000047322.6
 Rbbp8
retinoblastoma binding protein 8
chr2_-_127133909 0.805 ENSMUST00000110387.3
 Ncaph
non-SMC condensin I complex, subunit H
chr3_-_84155762 0.794 ENSMUST00000047368.6
 Mnd1
meiotic nuclear divisions 1 homolog (S. cerevisiae)
chr5_-_100719675 0.793 ENSMUST00000112908.1
ENSMUST00000045617.8
 Hpse

heparanase

chr13_+_117220584 0.784 ENSMUST00000022242.7
 Emb
embigin
chr11_-_100759740 0.767 ENSMUST00000107361.2
 Kcnh4
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr6_+_7555053 0.754 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr19_+_21778325 0.754 ENSMUST00000096194.2
ENSMUST00000025663.6
 Tmem2

transmembrane protein 2

chr15_+_102296256 0.738 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 86 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0043486 histone exchange(GO:0043486)
0.1 1.8 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 1.1 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 1.0 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.1 1.0 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 1.0 GO:0042148 strand invasion(GO:0042148)
0.2 0.9 GO:0035624 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625) response to high density lipoprotein particle(GO:0055099)
0.1 0.9 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.3 0.8 GO:2000373 regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000371) positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity(GO:2000373)
0.3 0.8 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.3 0.8 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.2 0.8 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1 0.8 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.8 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.2 0.7 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.1 0.7 GO:0051307 meiotic chromosome separation(GO:0051307)
0.0 0.7 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.7 GO:0060033 anatomical structure regression(GO:0060033)
0.0 0.7 GO:0048511 rhythmic process(GO:0048511)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 45 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.0 GO:0000796 condensin complex(GO:0000796)
0.0 1.0 GO:0016592 mediator complex(GO:0016592)
0.2 0.9 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.3 0.8 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 0.7 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.6 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 0.6 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.6 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.1 0.5 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.5 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.5 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.4 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.4 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 51 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 1.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 1.1 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 1.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 1.0 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.1 1.0 GO:0000150 recombinase activity(GO:0000150)
0.1 0.9 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 0.8 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 0.8 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 0.8 GO:0045545 syndecan binding(GO:0045545)
0.0 0.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 0.7 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.7 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.7 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.7 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.7 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.6 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 0.5 GO:0001069 regulatory region RNA binding(GO:0001069)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.9 PID_ATM_PATHWAY ATM pathway
0.0 1.8 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.0 PID_E2F_PATHWAY E2F transcription factor network
0.0 0.9 PID_ERBB4_PATHWAY ErbB4 signaling events
0.0 0.9 PID_ERA_GENOMIC_PATHWAY Validated nuclear estrogen receptor alpha network
0.0 0.7 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.4 PID_S1P_S1P2_PATHWAY S1P2 pathway
0.0 0.2 PID_INTEGRIN4_PATHWAY Alpha6 beta4 integrin-ligand interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.3 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 2.6 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.0 2.0 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.1 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.9 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 0.9 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 0.9 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.8 REACTOME_HS_GAG_DEGRADATION Genes involved in HS-GAG degradation
0.0 0.6 REACTOME_KINESINS Genes involved in Kinesins
0.0 0.6 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.5 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.4 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.0 0.4 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.4 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.4 REACTOME_ELONGATION_ARREST_AND_RECOVERY Genes involved in Elongation arrest and recovery
0.0 0.3 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0 0.3 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.2 REACTOME_ERKS_ARE_INACTIVATED Genes involved in ERKs are inactivated