Motif ID: Tcf7_Tcf7l2

Z-value: 0.931

Transcription factors associated with Tcf7_Tcf7l2:

Gene SymbolEntrez IDGene Name
Tcf7 ENSMUSG00000000782.9 Tcf7
Tcf7l2 ENSMUSG00000024985.12 Tcf7l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l2mm10_v2_chr19_+_55741884_557419190.391.0e-01Click!
Tcf7mm10_v2_chr11_-_52282564_522825790.253.2e-01Click!


Activity profile for motif Tcf7_Tcf7l2.

activity profile for motif Tcf7_Tcf7l2


Sorted Z-values histogram for motif Tcf7_Tcf7l2

Sorted Z-values for motif Tcf7_Tcf7l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7_Tcf7l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_65512678 1.516 ENSMUST00000081471.2
 Gm10139
predicted gene 10139
chr2_+_20737306 1.205 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr10_-_116972609 1.187 ENSMUST00000092165.4
 Gm10271
predicted gene 10271
chrX_-_134161928 1.165 ENSMUST00000033611.4
 Xkrx
X Kell blood group precursor related X linked
chr7_+_67655414 0.990 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr5_+_90759299 0.850 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5
chr1_+_157458554 0.840 ENSMUST00000046743.4
ENSMUST00000119891.1
 BC026585

cDNA sequence BC026585

chr6_-_85762480 0.839 ENSMUST00000168531.1
 Cml3
camello-like 3
chr15_+_102296256 0.832 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr3_+_137671524 0.792 ENSMUST00000166899.2
 Gm21962
predicted gene, 21962
chr7_+_45216671 0.725 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr4_+_121039385 0.707 ENSMUST00000030372.5
 Col9a2
collagen, type IX, alpha 2
chr6_+_117168535 0.688 ENSMUST00000112866.1
ENSMUST00000112871.1
ENSMUST00000073043.4
 Cxcl12


chemokine (C-X-C motif) ligand 12


chr7_-_144939823 0.685 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr17_-_47016956 0.681 ENSMUST00000165525.1
 Gm16494
predicted gene 16494
chr15_+_85859689 0.664 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr16_+_10812915 0.662 ENSMUST00000115822.1
 Gm11172
predicted gene 11172
chr1_+_88227005 0.654 ENSMUST00000061013.6
ENSMUST00000113130.1
 Mroh2a

maestro heat-like repeat family member 2A

chr5_-_44102032 0.648 ENSMUST00000171543.1
 Prom1
prominin 1
chr7_+_27499315 0.635 ENSMUST00000098644.2
ENSMUST00000108355.1
 Prx

periaxin


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0048706 embryonic skeletal system development(GO:0048706)
0.4 1.2 GO:0061181 regulation of chondrocyte development(GO:0061181)
0.1 1.2 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 1.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 1.0 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.3 0.9 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.0 0.8 GO:0001947 heart looping(GO:0001947)
0.2 0.7 GO:0006982 response to lipid hydroperoxide(GO:0006982) cellular response to lipid hydroperoxide(GO:0071449)
0.2 0.7 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.7 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.0 0.7 GO:0048368 lateral mesoderm development(GO:0048368)
0.2 0.6 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.2 0.6 GO:0030421 defecation(GO:0030421)
0.1 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.6 GO:0060539 diaphragm development(GO:0060539)
0.2 0.5 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
0.2 0.5 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.1 0.5 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.1 0.5 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.5 GO:0038092 nodal signaling pathway(GO:0038092)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 GO:0010369 chromocenter(GO:0010369)
0.0 0.8 GO:0072686 mitotic spindle(GO:0072686)
0.2 0.7 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 0.6 GO:0071914 prominosome(GO:0071914)
0.2 0.6 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.5 GO:0072687 meiotic spindle(GO:0072687)
0.0 0.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.5 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.5 GO:0031105 septin complex(GO:0031105)
0.0 0.5 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.1 0.4 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.1 0.4 GO:0033269 internode region of axon(GO:0033269)
0.1 0.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.1 0.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.3 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.3 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.1 1.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.9 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.8 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.8 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 0.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 0.6 GO:0070087 chromo shadow domain binding(GO:0070087)
0.1 0.6 GO:0015197 peptide transporter activity(GO:0015197)
0.2 0.5 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.1 0.5 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.0 0.5 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0 0.5 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.5 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.1 0.4 GO:0036132 13-prostaglandin reductase activity(GO:0036132) 15-oxoprostaglandin 13-oxidase activity(GO:0047522)
0.1 0.4 GO:0004458 D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.1 0.4 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.4 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.1 PID_SYNDECAN_4_PATHWAY Syndecan-4-mediated signaling events
0.0 1.0 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 PID_P38_MK2_PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 0.8 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.7 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.7 PID_SYNDECAN_1_PATHWAY Syndecan-1-mediated signaling events
0.0 0.6 PID_BETA_CATENIN_DEG_PATHWAY Degradation of beta catenin
0.0 0.5 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.5 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.5 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.5 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 0.3 PID_THROMBIN_PAR4_PATHWAY PAR4-mediated thrombin signaling events
0.0 0.3 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4
0.0 0.3 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 0.2 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods
0.0 0.2 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.1 PID_ERBB2_ERBB3_PATHWAY ErbB2/ErbB3 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.1 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.1 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.0 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.8 REACTOME_PRE_NOTCH_TRANSCRIPTION_AND_TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.8 REACTOME_SMAD2_SMAD3_SMAD4_HETEROTRIMER_REGULATES_TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 0.7 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.6 REACTOME_CHOLESTEROL_BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.6 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.4 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 0.3 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.3 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.3 REACTOME_BASE_FREE_SUGAR_PHOSPHATE_REMOVAL_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.3 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.3 REACTOME_ACYL_CHAIN_REMODELLING_OF_PC Genes involved in Acyl chain remodelling of PC
0.0 0.3 REACTOME_SULFUR_AMINO_ACID_METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.3 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.0 0.3 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)