ISMARA results: Ebf3

Motif ID: Ebf3

Z-value: 1.288

Transcription factors associated with Ebf3:

Gene Symbol	Entrez ID	Gene Name
Ebf3	ENSMUSG00000010476.7	Ebf3

Activity-expression correlation:

Gene Symbol	Promoter	Pearson corr. coef.	P-value	Plot
Ebf3	mm10_v2_chr7_-_137314394_137314445	-0.56	1.6e-02	Click!

View svg image
View png image

Top targets:

Search:

Show entries

Showing 1 to 20 of 200 entries

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr15_-_66812593	7.111	ENSMUST00000100572.3	Sla	src-like adaptor
chr5_+_117781017	6.061	ENSMUST00000138579.2	Nos1	nitric oxide synthase 1, neuronal
chr11_-_98053415	4.376	ENSMUST00000017544.2	Stac2	SH3 and cysteine rich domain 2
chr1_-_56969864	3.608	ENSMUST00000177424.1	Satb2	special AT-rich sequence binding protein 2
chr1_-_56969827	3.466	ENSMUST00000176759.1	Satb2	special AT-rich sequence binding protein 2
chr11_+_104231573	3.433	ENSMUST00000132977.1 ENSMUST00000132245.1 ENSMUST00000100347.4	Mapt	microtubule-associated protein tau
chr10_+_112271123	3.235	ENSMUST00000092175.2	Kcnc2	potassium voltage gated channel, Shaw-related subfamily, member 2
chr11_+_104231515	3.201	ENSMUST00000106993.3	Mapt	microtubule-associated protein tau
chr11_+_104231465	3.011	ENSMUST00000145227.1	Mapt	microtubule-associated protein tau
chr5_-_139130159	2.774	ENSMUST00000129851.1	Prkar1b	protein kinase, cAMP dependent regulatory, type I beta
chr1_-_154725920	2.644	ENSMUST00000004214.8	Cacna1e	calcium channel, voltage-dependent, R type, alpha 1E subunit
chr5_-_139129662	2.622	ENSMUST00000026973.7	Prkar1b	protein kinase, cAMP dependent regulatory, type I beta
chr11_+_104231390	2.568	ENSMUST00000106992.3	Mapt	microtubule-associated protein tau
chr1_-_173367638	2.479	ENSMUST00000005470.4 ENSMUST00000111220.1	Cadm3	cell adhesion molecule 3
chr8_+_70493156	2.448	ENSMUST00000008032.7	Crlf1	cytokine receptor-like factor 1
chr9_-_58313189	2.299	ENSMUST00000061799.8	Loxl1	lysyl oxidase-like 1
chr4_-_129121234	2.224	ENSMUST00000030572.3	Hpca	hippocalcin
chr7_+_123982799	2.138	ENSMUST00000106437.1	Hs3st4	heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr4_-_129121699	2.131	ENSMUST00000135763.1 ENSMUST00000149763.1 ENSMUST00000164649.1	Hpca	hippocalcin
chr14_-_60086832	2.095	ENSMUST00000080368.5	Atp8a2	ATPase, aminophospholipid transporter-like, class I, type 8A, member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Showing 1 to 20 of 124 entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	14.1	GO:1902474	positive regulation of protein localization to synapse(GO:1902474)
0.4	7.1	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.0	6.1	GO:0099548	drug catabolic process(GO:0042737) exogenous drug catabolic process(GO:0042738) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by nitric oxide(GO:0099548)
0.4	5.4	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
1.5	4.4	GO:0030827	negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.1	4.2	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5	4.1	GO:0050908	detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0	3.8	GO:0018107	peptidyl-threonine phosphorylation(GO:0018107)
0.2	3.5	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.5	3.3	GO:0097473	cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473)
0.3	3.2	GO:1903818	positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.4	2.8	GO:1990573	potassium ion import across plasma membrane(GO:1990573)
0.5	2.6	GO:0090273	regulation of somatostatin secretion(GO:0090273)
0.0	2.5	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.4	2.4	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.1	2.3	GO:0032288	myelin assembly(GO:0032288)
0.1	2.3	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1	2.0	GO:0035020	regulation of Rac protein signal transduction(GO:0035020)
0.2	1.8	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.1	1.8	GO:0051764	actin crosslink formation(GO:0051764)

Gene overrepresentation in cellular_component category:

Search:

Show entries

Showing 1 to 20 of 66 entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	12.2	GO:0045298	tubulin complex(GO:0045298)
0.1	7.3	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.6	6.1	GO:0042582	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1	5.8	GO:0000118	histone deacetylase complex(GO:0000118)
0.4	5.4	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.4	5.3	GO:0008385	IkappaB kinase complex(GO:0008385)
0.1	4.7	GO:0032809	neuronal cell body membrane(GO:0032809)
0.3	4.4	GO:0044327	dendritic spine head(GO:0044327)
0.1	4.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.1	4.2	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
0.2	3.3	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	2.8	GO:0005913	cell-cell adherens junction(GO:0005913)
0.8	2.4	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	2.3	GO:0001669	acrosomal vesicle(GO:0001669)
0.1	2.2	GO:0031941	filamentous actin(GO:0031941)
0.1	2.0	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.6	1.8	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.2	1.8	GO:0097433	dense body(GO:0097433)
0.0	1.8	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.4	1.7	GO:1990769	proximal neuron projection(GO:1990769)

Gene overrepresentation in molecular_function category:

Search:

Show entries

Showing 1 to 20 of 82 entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.7	12.2	GO:0099609	microtubule lateral binding(GO:0099609)
0.2	7.1	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
2.0	6.1	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.5	5.4	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	4.8	GO:0003779	actin binding(GO:0003779)
0.3	4.4	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	3.8	GO:0005080	protein kinase C binding(GO:0005080)
0.0	3.7	GO:0030165	PDZ domain binding(GO:0030165)
0.1	3.6	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.2	3.2	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.4	3.0	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.6	2.8	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.3	2.7	GO:0035374	chondroitin sulfate binding(GO:0035374)
0.0	2.6	GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.2	2.3	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.2	2.3	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1	2.1	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	2.0	GO:0004721	phosphoprotein phosphatase activity(GO:0004721)
0.2	1.8	GO:0008199	ferric iron binding(GO:0008199)
0.1	1.8	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)

Gene overrepresentation in C2:CP category:

Search:

Show entries

Showing 1 to 19 of 19 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	12.2	PID_P38_GAMMA_DELTA_PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	6.1	PID_PDGFRB_PATHWAY	PDGFR-beta signaling pathway
0.1	4.4	PID_IL1_PATHWAY	IL1-mediated signaling events
0.1	4.1	SA_TRKA_RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1	3.6	PID_INTEGRIN_A4B1_PATHWAY	Alpha4 beta1 integrin signaling events
0.0	3.3	NABA_ECM_REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	3.1	PID_A6B1_A6B4_INTEGRIN_PATHWAY	a6b1 and a6b4 Integrin signaling
0.1	2.9	ST_MYOCYTE_AD_PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	2.2	NABA_SECRETED_FACTORS	Genes encoding secreted soluble factors
0.1	2.0	PID_RET_PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.1	1.8	PID_RAS_PATHWAY	Regulation of Ras family activation
0.0	1.8	ST_JNK_MAPK_PATHWAY	JNK MAPK Pathway
0.2	1.6	SA_MMP_CYTOKINE_CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	1.5	PID_NETRIN_PATHWAY	Netrin-mediated signaling events
0.0	0.8	PID_ARF6_TRAFFICKING_PATHWAY	Arf6 trafficking events
0.0	0.6	PID_IL27_PATHWAY	IL27-mediated signaling events
0.0	0.5	PID_HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.4	PID_ARF6_DOWNSTREAM_PATHWAY	Arf6 downstream pathway
0.0	0.3	PID_SYNDECAN_2_PATHWAY	Syndecan-2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Showing 1 to 20 of 36 entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	11.9	REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.3	6.7	REACTOME_CRMPS_IN_SEMA3A_SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.2	5.7	REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.2	5.4	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.1	5.4	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	Genes involved in Voltage gated Potassium channels
0.2	3.3	REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.1	3.1	REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	2.8	REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1	2.4	REACTOME_RAS_ACTIVATION_UOPN_CA2_INFUX_THROUGH_NMDA_RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1	2.1	REACTOME_HS_GAG_BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	2.1	REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	1.9	REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.2	1.8	REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	1.7	REACTOME_NCAM1_INTERACTIONS	Genes involved in NCAM1 interactions
0.0	1.7	REACTOME_REGULATION_OF_INSULIN_SECRETION	Genes involved in Regulation of Insulin Secretion
0.1	1.5	REACTOME_ROLE_OF_DCC_IN_REGULATING_APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.1	1.5	REACTOME_ABCA_TRANSPORTERS_IN_LIPID_HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	1.5	REACTOME_LYSOSOME_VESICLE_BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	1.3	REACTOME_RAP1_SIGNALLING	Genes involved in Rap1 signalling
0.1	1.2	REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)