Motif ID: Gata2_Gata1

Z-value: 0.548

Transcription factors associated with Gata2_Gata1:

Gene SymbolEntrez IDGene Name
Gata1 ENSMUSG00000031162.8 Gata1
Gata2 ENSMUSG00000015053.8 Gata2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gata1mm10_v2_chrX_-_7967817_79679100.272.7e-01Click!
Gata2mm10_v2_chr6_+_88198656_881986750.029.2e-01Click!


Activity profile for motif Gata2_Gata1.

activity profile for motif Gata2_Gata1


Sorted Z-values histogram for motif Gata2_Gata1

Sorted Z-values for motif Gata2_Gata1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata2_Gata1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 155 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_84701430 1.170 ENSMUST00000037165.4
 Lyl1
lymphoblastomic leukemia 1
chr3_-_154330543 1.047 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr5_-_73191848 0.953 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr7_-_139582790 0.917 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr19_-_42202150 0.752 ENSMUST00000018966.7
 Sfrp5
secreted frizzled-related sequence protein 5
chr7_+_110627650 0.584 ENSMUST00000033054.8
 Adm
adrenomedullin
chr11_+_32276893 0.570 ENSMUST00000145569.1
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr11_+_32276400 0.542 ENSMUST00000020531.2
 Hba-x
hemoglobin X, alpha-like embryonic chain in Hba complex
chr1_-_162866502 0.479 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr11_+_90030295 0.463 ENSMUST00000092788.3
 Tmem100
transmembrane protein 100
chr11_-_64436653 0.456 ENSMUST00000177999.1
 F930015N05Rik
RIKEN cDNA F930015N05 gene
chr3_+_135825788 0.446 ENSMUST00000167390.1
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr9_-_32541589 0.441 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr11_-_102469839 0.415 ENSMUST00000103086.3
 Itga2b
integrin alpha 2b
chr3_+_79884576 0.414 ENSMUST00000145992.1
 Fam198b
family with sequence similarity 198, member B
chr8_+_13037308 0.397 ENSMUST00000063820.5
ENSMUST00000033821.4
 F10

coagulation factor X

chr13_+_38345716 0.360 ENSMUST00000171970.1
 Bmp6
bone morphogenetic protein 6
chr2_-_121037048 0.359 ENSMUST00000102490.3
 Epb4.2
erythrocyte protein band 4.2
chr2_-_153241402 0.349 ENSMUST00000056924.7
 Plagl2
pleiomorphic adenoma gene-like 2
chr15_-_103251465 0.341 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.2 GO:0001955 blood vessel maturation(GO:0001955)
0.2 1.1 GO:0015671 oxygen transport(GO:0015671)
0.1 1.0 GO:0090527 actin filament reorganization(GO:0090527)
0.1 0.9 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.9 GO:0021884 forebrain neuron development(GO:0021884)
0.3 0.8 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 0.7 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.1 0.6 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.1 0.5 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.5 GO:0070995 toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995)
0.1 0.4 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.0 0.4 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 0.4 GO:0034377 plasma lipoprotein particle assembly(GO:0034377)
0.0 0.4 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.3 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 0.3 GO:0019532 oxalate transport(GO:0019532)
0.0 0.3 GO:0002326 B cell lineage commitment(GO:0002326)
0.0 0.3 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.3 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0 0.3 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.1 GO:0005833 hemoglobin complex(GO:0005833)
0.2 1.0 GO:0001674 female germ cell nucleus(GO:0001674)
0.0 0.5 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.4 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 0.1 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0 0.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.1 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.1 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.5 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.4 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 0.4 GO:0070051 fibrinogen binding(GO:0070051)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.0 0.3 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.0 0.3 GO:0019531 secondary active sulfate transmembrane transporter activity(GO:0008271) oxalate transmembrane transporter activity(GO:0019531)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 0.2 GO:0016748 succinyltransferase activity(GO:0016748)
0.1 0.2 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.0 0.2 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.1 GO:0005119 smoothened binding(GO:0005119) hedgehog receptor activity(GO:0008158)
0.0 0.1 GO:0030172 troponin C binding(GO:0030172)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.5 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.4 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.1 PID_ALK2_PATHWAY ALK2 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.5 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.5 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 0.4 REACTOME_COMMON_PATHWAY Genes involved in Common Pathway
0.0 0.4 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.2 REACTOME_TRANSLOCATION_OF_ZAP_70_TO_IMMUNOLOGICAL_SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 0.2 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.2 REACTOME_REGULATION_OF_KIT_SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.1 REACTOME_GAMMA_CARBOXYLATION_TRANSPORT_AND_AMINO_TERMINAL_CLEAVAGE_OF_PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins