Motif ID: Fos

Z-value: 0.987


Transcription factors associated with Fos:

Gene SymbolEntrez IDGene Name
Fos ENSMUSG00000021250.7 Fos

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Fosmm10_v2_chr12_+_85473883_85473896-0.465.7e-02Click!


Activity profile for motif Fos.

activity profile for motif Fos


Sorted Z-values histogram for motif Fos

Sorted Z-values for motif Fos



Network of associatons between targets according to the STRING database.



First level regulatory network of Fos

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_+_43952999 3.743 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr2_+_20737306 3.567 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr17_+_43953191 3.432 ENSMUST00000044792.4
 Rcan2
regulator of calcineurin 2
chr18_+_82910863 3.332 ENSMUST00000171238.1
 Zfp516
zinc finger protein 516
chr16_-_44558864 3.201 ENSMUST00000023370.4
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr1_+_107511489 3.162 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 3.068 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr2_+_30078584 3.056 ENSMUST00000045246.7
 Pkn3
protein kinase N3
chr2_+_13573927 3.047 ENSMUST00000141365.1
ENSMUST00000028062.2
 Vim

vimentin

chr13_+_15463837 2.979 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chr16_-_44558879 2.875 ENSMUST00000114634.1
 Boc
biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein
chr2_+_167777467 2.799 ENSMUST00000139927.1
ENSMUST00000127441.1
 Gm14321

predicted gene 14321

chr7_-_126799163 2.581 ENSMUST00000032934.5
 Aldoa
aldolase A, fructose-bisphosphate
chr7_-_126799134 2.480 ENSMUST00000087566.4
 Aldoa
aldolase A, fructose-bisphosphate
chr13_-_23991158 2.422 ENSMUST00000021770.7
 Scgn
secretagogin, EF-hand calcium binding protein
chr7_-_45920830 2.411 ENSMUST00000164119.1
 Emp3
epithelial membrane protein 3
chr1_+_109993982 2.251 ENSMUST00000027542.6
 Cdh7
cadherin 7, type 2
chr6_+_7555053 2.240 ENSMUST00000090679.2
ENSMUST00000184986.1
 Tac1

tachykinin 1

chr5_+_42067960 2.187 ENSMUST00000087332.4
 Gm16223
predicted gene 16223
chr7_+_27486910 2.167 ENSMUST00000008528.7
 Sertad1
SERTA domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 7.2 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.2 6.1 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.0 5.7 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.5 5.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 3.9 GO:0007179 transforming growth factor beta receptor signaling pathway(GO:0007179)
0.1 3.8 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 3.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.0 3.0 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.6 3.0 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.9 2.8 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1 2.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 2.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.7 2.2 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.1 2.2 GO:0043486 histone exchange(GO:0043486)
0.0 2.1 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.0 GO:1902476 chloride transmembrane transport(GO:1902476)
0.5 1.9 GO:2001045 negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.4 1.9 GO:0072675 osteoclast fusion(GO:0072675)
0.1 1.9 GO:0006825 copper ion transport(GO:0006825)
0.6 1.8 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.4 GO:0044295 axonal growth cone(GO:0044295)
0.4 5.1 GO:0035686 sperm fibrous sheath(GO:0035686)
0.8 3.0 GO:0045098 type III intermediate filament(GO:0045098)
0.3 3.0 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 2.9 GO:0034707 chloride channel complex(GO:0034707)
0.1 2.7 GO:0016592 mediator complex(GO:0016592)
0.0 2.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 2.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.2 1.9 GO:0005915 zonula adherens(GO:0005915)
0.1 1.9 GO:0005839 proteasome core complex(GO:0005839)
0.0 1.9 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 1.7 GO:0031519 PcG protein complex(GO:0031519)
0.5 1.6 GO:1990047 spindle matrix(GO:1990047)
0.1 1.5 GO:0098644 complex of collagen trimers(GO:0098644)
0.1 1.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.3 1.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 1.3 GO:0009986 cell surface(GO:0009986)
0.0 1.3 GO:0000786 nucleosome(GO:0000786)
0.1 1.2 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 89 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.2 7.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 5.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.8 5.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.2 4.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.8 3.3 GO:1990254 keratin filament binding(GO:1990254)
0.2 3.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 3.1 GO:0004697 protein kinase C activity(GO:0004697)
0.0 3.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.2 2.8 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 2.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 2.2 GO:0019212 phosphatase inhibitor activity(GO:0019212)
0.0 2.0 GO:0005254 chloride channel activity(GO:0005254)
0.4 1.9 GO:0004322 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 1.9 GO:0017166 vinculin binding(GO:0017166)
0.1 1.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 1.9 GO:0001671 ATPase activator activity(GO:0001671)
0.4 1.8 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 1.8 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 6.4 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 6.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 4.6 PID_ECADHERIN_KERATINOCYTE_PATHWAY E-cadherin signaling in keratinocytes
0.1 3.2 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 3.0 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.1 2.4 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.1 1.5 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.2 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.1 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 1.1 PID_VEGFR1_2_PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.0 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.0 PID_FAK_PATHWAY Signaling events mediated by focal adhesion kinase
0.0 0.9 ST_G_ALPHA_S_PATHWAY G alpha s Pathway
0.0 0.8 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.8 PID_ECADHERIN_NASCENT_AJ_PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.8 PID_RAS_PATHWAY Regulation of Ras family activation
0.0 0.8 SIG_CD40PATHWAYMAP Genes related to CD40 signaling
0.0 0.8 NABA_COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 8.6 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.1 7.2 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 4.1 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 3.1 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 3.0 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.9 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 1.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 1.6 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.1 1.5 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.2 1.4 REACTOME_THE_NLRP3_INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.4 REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_DAI Genes involved in RIP-mediated NFkB activation via DAI
0.0 1.4 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 Genes involved in Signal transduction by L1
0.2 1.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 1.2 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.1 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 1.1 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.0 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.9 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 0.8 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.7 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks