Motif ID: Tcf4_Mesp1

Z-value: 2.247

Transcription factors associated with Tcf4_Mesp1:

Gene SymbolEntrez IDGene Name
Mesp1 ENSMUSG00000030544.5 Mesp1
Tcf4 ENSMUSG00000053477.9 Tcf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4mm10_v2_chr18_+_69593361_695934500.744.4e-04Click!


Activity profile for motif Tcf4_Mesp1.

activity profile for motif Tcf4_Mesp1


Sorted Z-values histogram for motif Tcf4_Mesp1

Sorted Z-values for motif Tcf4_Mesp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf4_Mesp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 19.349 ENSMUST00000164163.1
 Sla
src-like adaptor
chr13_-_57907587 15.085 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr11_-_67922136 11.716 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr13_+_83504032 11.483 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr5_+_37028329 10.135 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr5_-_139130159 8.608 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr10_+_123264076 7.309 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr9_-_29411736 7.193 ENSMUST00000115236.1
 Ntm
neurotrimin
chr12_+_82616885 7.172 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr16_-_97170707 6.733 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr16_+_11984581 6.654 ENSMUST00000170672.2
ENSMUST00000023138.7
 Shisa9

shisa homolog 9 (Xenopus laevis)

chr14_+_101729907 6.651 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr10_+_89873497 6.599 ENSMUST00000183156.1
ENSMUST00000182936.1
ENSMUST00000099368.4
 Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr14_-_30353468 5.966 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr11_+_42419729 5.779 ENSMUST00000007797.4
 Gabrb2
gamma-aminobutyric acid (GABA) A receptor, subunit beta 2
chr1_-_158356258 5.628 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr11_+_103171081 5.613 ENSMUST00000042286.5
 Fmnl1
formin-like 1
chr12_-_79007276 5.394 ENSMUST00000056660.6
ENSMUST00000174721.1
 Tmem229b

transmembrane protein 229B

chr2_-_121806988 5.070 ENSMUST00000110592.1
 Frmd5
FERM domain containing 5
chr6_+_58831748 5.007 ENSMUST00000126292.1
ENSMUST00000031823.5
 Herc3

hect domain and RLD 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 575 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 13.4 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
1.3 12.5 GO:0048149 behavioral response to ethanol(GO:0048149)
0.7 12.2 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.6 11.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
3.9 11.6 GO:0007521 muscle cell fate determination(GO:0007521)
0.4 9.8 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.4 9.6 GO:0008209 androgen metabolic process(GO:0008209)
0.1 9.5 GO:0016579 protein deubiquitination(GO:0016579)
0.1 9.0 GO:0050890 cognition(GO:0050890)
0.7 8.8 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 8.7 GO:1903749 positive regulation of establishment of protein localization to mitochondrion(GO:1903749) positive regulation of protein targeting to mitochondrion(GO:1903955)
0.2 8.4 GO:0034605 cellular response to heat(GO:0034605)
0.2 8.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.9 7.9 GO:0071420 cellular response to histamine(GO:0071420)
0.1 7.8 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.1 7.8 GO:0031032 actomyosin structure organization(GO:0031032)
0.2 7.7 GO:0008333 endosome to lysosome transport(GO:0008333)
0.3 7.4 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.9 7.1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.7 7.0 GO:0046959 habituation(GO:0046959)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 193 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 42.4 GO:0060076 excitatory synapse(GO:0060076)
0.3 42.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 18.3 GO:0005802 trans-Golgi network(GO:0005802)
0.6 17.3 GO:0033268 node of Ranvier(GO:0033268)
0.1 17.1 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 14.5 GO:0030139 endocytic vesicle(GO:0030139)
0.2 14.0 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3 11.4 GO:0032809 neuronal cell body membrane(GO:0032809)
0.3 11.3 GO:0048786 presynaptic active zone(GO:0048786)
0.7 10.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.7 9.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 8.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 8.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 7.8 GO:0032587 ruffle membrane(GO:0032587)
0.1 7.5 GO:0030016 myofibril(GO:0030016)
0.4 7.4 GO:0032279 asymmetric synapse(GO:0032279)
0.1 7.4 GO:0005769 early endosome(GO:0005769)
0.7 7.0 GO:0032591 dendritic spine membrane(GO:0032591)
0.3 6.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.6 5.8 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 363 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 26.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 19.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.8 14.3 GO:0050811 GABA receptor binding(GO:0050811)
0.2 14.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 13.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.7 12.6 GO:0035198 miRNA binding(GO:0035198)
0.3 12.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 11.5 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.3 11.2 GO:0030552 cAMP binding(GO:0030552)
0.7 11.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.4 10.5 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 10.5 GO:0030695 GTPase regulator activity(GO:0030695)
0.9 10.3 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.3 9.3 GO:0042805 actinin binding(GO:0042805)
0.4 9.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.8 9.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.6 7.4 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.2 7.2 GO:0030507 spectrin binding(GO:0030507)
1.0 6.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 6.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 67 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 28.8 PID_PDGFRB_PATHWAY PDGFR-beta signaling pathway
0.4 17.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 14.7 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.2 12.4 PID_TRKR_PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.3 11.2 NABA_PROTEOGLYCANS Genes encoding proteoglycans
0.2 10.9 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.2 9.9 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.2 8.3 PID_REELIN_PATHWAY Reelin signaling pathway
0.2 8.1 PID_LKB1_PATHWAY LKB1 signaling events
0.2 7.5 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.2 6.4 PID_P38_MKK3_6PATHWAY p38 MAPK signaling pathway
0.2 6.2 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 5.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.2 5.0 PID_CD8_TCR_PATHWAY TCR signaling in naïve CD8+ T cells
0.2 4.9 PID_ARF6_DOWNSTREAM_PATHWAY Arf6 downstream pathway
0.2 4.6 PID_INTEGRIN_A4B1_PATHWAY Alpha4 beta1 integrin signaling events
0.2 4.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.4 4.3 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 4.0 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.5 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 13.2 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.3 12.4 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.4 11.4 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.6 10.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.4 9.5 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.4 9.0 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.2 8.9 REACTOME_EGFR_DOWNREGULATION Genes involved in EGFR downregulation
0.2 7.7 REACTOME_EFFECTS_OF_PIP2_HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 7.1 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.5 7.0 REACTOME_DSCAM_INTERACTIONS Genes involved in DSCAM interactions
0.4 6.3 REACTOME_POST_CHAPERONIN_TUBULIN_FOLDING_PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 6.3 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.4 5.8 REACTOME_NUCLEOTIDE_LIKE_PURINERGIC_RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.2 5.8 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.3 5.7 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.1 5.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
1.4 5.5 REACTOME_GLYCOPROTEIN_HORMONES Genes involved in Glycoprotein hormones
0.3 5.4 REACTOME_DCC_MEDIATED_ATTRACTIVE_SIGNALING Genes involved in DCC mediated attractive signaling
0.4 5.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 4.8 REACTOME_TIE2_SIGNALING Genes involved in Tie2 Signaling