Motif ID: Gata6

Z-value: 0.541


Transcription factors associated with Gata6:

Gene SymbolEntrez IDGene Name
Gata6 ENSMUSG00000005836.8 Gata6



Activity profile for motif Gata6.

activity profile for motif Gata6


Sorted Z-values histogram for motif Gata6

Sorted Z-values for motif Gata6



Network of associatons between targets according to the STRING database.



First level regulatory network of Gata6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_-_86732409 1.317 ENSMUST00000070435.4
 Fabp3-ps1
fatty acid binding protein 3, muscle and heart, pseudogene 1
chr10_-_62342674 1.067 ENSMUST00000143179.1
ENSMUST00000130422.1
 Hk1

hexokinase 1

chr6_+_58833689 1.042 ENSMUST00000041401.8
 Herc3
hect domain and RLD 3
chr9_-_29963112 1.014 ENSMUST00000075069.4
 Ntm
neurotrimin
chr12_+_95692212 0.972 ENSMUST00000057324.3
 Flrt2
fibronectin leucine rich transmembrane protein 2
chr11_+_67586675 0.944 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr2_+_65930117 0.900 ENSMUST00000176109.1
 Csrnp3
cysteine-serine-rich nuclear protein 3
chr4_+_13751297 0.861 ENSMUST00000105566.2
 Runx1t1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr6_+_58831748 0.809 ENSMUST00000126292.1
ENSMUST00000031823.5
 Herc3

hect domain and RLD 3

chr1_+_152954966 0.804 ENSMUST00000043313.8
 Nmnat2
nicotinamide nucleotide adenylyltransferase 2
chr3_-_154330543 0.800 ENSMUST00000184966.1
ENSMUST00000177846.2
 Lhx8

LIM homeobox protein 8

chr19_+_58670358 0.750 ENSMUST00000057270.7
 Pnlip
pancreatic lipase
chr9_+_66350465 0.742 ENSMUST00000042824.6
 Herc1
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
chr6_+_86078070 0.705 ENSMUST00000032069.5
 Add2
adducin 2 (beta)
chr1_-_162866502 0.628 ENSMUST00000046049.7
 Fmo1
flavin containing monooxygenase 1
chr5_+_76840597 0.601 ENSMUST00000120639.2
ENSMUST00000163347.1
ENSMUST00000121851.1
 C530008M17Rik


RIKEN cDNA C530008M17 gene


chr2_-_7081207 0.598 ENSMUST00000114923.2
ENSMUST00000182706.1
 Celf2

CUGBP, Elav-like family member 2

chr2_-_7396192 0.589 ENSMUST00000137733.2
 Celf2
CUGBP, Elav-like family member 2
chr2_+_68104671 0.582 ENSMUST00000042456.3
 B3galt1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr15_+_18818895 0.467 ENSMUST00000166873.2
 Cdh10
cadherin 10
chr11_+_3330781 0.456 ENSMUST00000136536.1
ENSMUST00000093399.4
 Pik3ip1

phosphoinositide-3-kinase interacting protein 1

chr2_-_7395879 0.454 ENSMUST00000182404.1
 Celf2
CUGBP, Elav-like family member 2
chr2_-_7081256 0.419 ENSMUST00000183209.1
 Celf2
CUGBP, Elav-like family member 2
chr2_-_77170592 0.349 ENSMUST00000164114.2
ENSMUST00000049544.7
 Ccdc141

coiled-coil domain containing 141

chr19_-_42202150 0.346 ENSMUST00000018966.7
 Sfrp5
secreted frizzled-related sequence protein 5
chr2_-_59948155 0.336 ENSMUST00000153136.1
 Baz2b
bromodomain adjacent to zinc finger domain, 2B
chr5_-_73191848 0.325 ENSMUST00000176910.1
 Fryl
furry homolog-like (Drosophila)
chr2_-_33087169 0.315 ENSMUST00000102810.3
 Garnl3
GTPase activating RANGAP domain-like 3
chr1_+_179803376 0.301 ENSMUST00000097454.2
 Gm10518
predicted gene 10518
chr18_+_76059458 0.299 ENSMUST00000167921.1
 Zbtb7c
zinc finger and BTB domain containing 7C
chr5_+_121777929 0.290 ENSMUST00000160821.1
 Atxn2
ataxin 2
chr7_+_110627650 0.288 ENSMUST00000033054.8
 Adm
adrenomedullin
chr17_-_33713372 0.262 ENSMUST00000173392.1
 March2
membrane-associated ring finger (C3HC4) 2
chr9_-_65827544 0.249 ENSMUST00000159109.1
 Zfp609
zinc finger protein 609
chr11_-_53707269 0.244 ENSMUST00000124352.1
ENSMUST00000020649.7
 Rad50

RAD50 homolog (S. cerevisiae)

chr5_-_30461902 0.239 ENSMUST00000133509.1
ENSMUST00000074171.6
ENSMUST00000114747.2
ENSMUST00000144125.1
 Otof



otoferlin



chr11_+_87581041 0.239 ENSMUST00000018544.5
ENSMUST00000063156.4
ENSMUST00000107960.1
 Sept4


septin 4


chr6_-_122609964 0.237 ENSMUST00000032211.4
 Gdf3
growth differentiation factor 3
chr5_+_19907502 0.233 ENSMUST00000101558.3
 Magi2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr19_+_4711153 0.219 ENSMUST00000008991.6
 Sptbn2
spectrin beta, non-erythrocytic 2
chr16_+_36041184 0.215 ENSMUST00000042203.8
 Wdr5b
WD repeat domain 5B
chr9_-_95815389 0.205 ENSMUST00000119760.1
 Pls1
plastin 1 (I-isoform)
chr2_-_33086366 0.205 ENSMUST00000049618.2
 Garnl3
GTPase activating RANGAP domain-like 3
chr1_-_173333503 0.198 ENSMUST00000038227.4
 Darc
Duffy blood group, chemokine receptor
chr2_-_7395968 0.193 ENSMUST00000002176.6
 Celf2
CUGBP, Elav-like family member 2
chr3_+_79885930 0.190 ENSMUST00000029567.8
 Fam198b
family with sequence similarity 198, member B
chr8_-_64205970 0.186 ENSMUST00000066166.4
 Tll1
tolloid-like
chr7_-_139582790 0.180 ENSMUST00000106095.2
 Nkx6-2
NK6 homeobox 2
chr16_-_34262945 0.179 ENSMUST00000114953.1
 Kalrn
kalirin, RhoGEF kinase
chr7_+_28833975 0.172 ENSMUST00000066723.8
 Lgals4
lectin, galactose binding, soluble 4
chrX_-_37110257 0.169 ENSMUST00000076265.6
 Upf3b
UPF3 regulator of nonsense transcripts homolog B (yeast)
chr1_-_25829511 0.167 ENSMUST00000135518.1
ENSMUST00000151309.1
 Bai3

brain-specific angiogenesis inhibitor 3

chr9_+_65032413 0.141 ENSMUST00000034960.6
 Dpp8
dipeptidylpeptidase 8
chr6_-_38124568 0.137 ENSMUST00000040259.4
 Atp6v0a4
ATPase, H+ transporting, lysosomal V0 subunit A4
chr5_-_111761697 0.131 ENSMUST00000129146.1
ENSMUST00000137398.1
ENSMUST00000129065.1
 E130006D01Rik


RIKEN cDNA E130006D01 gene


chr2_+_72476225 0.123 ENSMUST00000157019.1
 Cdca7
cell division cycle associated 7
chrX_+_10485121 0.118 ENSMUST00000076354.6
ENSMUST00000115526.1
 Tspan7

tetraspanin 7

chr16_+_91647859 0.111 ENSMUST00000119368.1
ENSMUST00000114037.2
ENSMUST00000114036.2
ENSMUST00000122302.1
 Son



Son DNA binding protein



chr16_-_64786321 0.111 ENSMUST00000052588.4
 Zfp654
zinc finger protein 654
chr17_+_71204647 0.105 ENSMUST00000126681.1
 Lpin2
lipin 2
chr4_-_46404224 0.100 ENSMUST00000107764.2
 Hemgn
hemogen
chr11_+_95712673 0.094 ENSMUST00000107717.1
 Zfp652
zinc finger protein 652
chr10_+_53337686 0.073 ENSMUST00000046221.6
ENSMUST00000163319.1
 Pln

phospholamban

chr16_+_58670208 0.040 ENSMUST00000060077.5
 Cpox
coproporphyrinogen oxidase
chr18_-_43477764 0.032 ENSMUST00000057110.9
 Eif3j2
eukaryotic translation initiation factor 3, subunit J2
chr15_-_83170498 0.032 ENSMUST00000162178.1
 Cyb5r3
cytochrome b5 reductase 3
chr15_-_83170168 0.023 ENSMUST00000162834.1
 Cyb5r3
cytochrome b5 reductase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.2 1.1 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.1 0.7 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.1 0.3 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.1 1.0 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.1 0.2 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.1 0.5 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.6 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 2.3 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.6 GO:0070995 toxin metabolic process(GO:0009404) NADPH oxidation(GO:0070995)
0.0 0.2 GO:0000019 regulation of mitotic recombination(GO:0000019) telomeric 3' overhang formation(GO:0031860)
0.0 0.3 GO:0097646 calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0 0.2 GO:0045605 negative regulation of epidermal cell differentiation(GO:0045605)
0.0 1.2 GO:0021692 cerebellar Purkinje cell layer morphogenesis(GO:0021692)
0.0 0.7 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 0.2 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.3 GO:1903025 regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0 0.3 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.2 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912) regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.2 GO:0061368 maternal process involved in parturition(GO:0060137) behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.1 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.9 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.2 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.0 0.8 GO:0021884 forebrain neuron development(GO:0021884)
0.0 0.9 GO:0010923 negative regulation of phosphatase activity(GO:0010923)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 0.4 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 1.1 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.2 GO:1990357 terminal web(GO:1990357)
0.0 0.2 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0097227 sperm annulus(GO:0097227)
0.0 0.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.2 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 0.8 GO:0004515 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.2 0.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.1 0.6 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 0.6 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.7 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 1.0 GO:0045499 chemorepellent activity(GO:0045499)
0.0 2.3 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0070699 type II activin receptor binding(GO:0070699)
0.0 0.2 GO:0051880 G-quadruplex DNA binding(GO:0051880)
0.0 0.1 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.2 GO:0016936 galactoside binding(GO:0016936)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.2 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.1 GO:0050733 RS domain binding(GO:0050733)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.7 GO:0030507 spectrin binding(GO:0030507)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0 0.6 REACTOME_PHASE1_FUNCTIONALIZATION_OF_COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.1 REACTOME_GLUCOSE_TRANSPORT Genes involved in Glucose transport
0.0 0.9 REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.2 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions