Motif ID: Tfcp2

Z-value: 2.113


Transcription factors associated with Tfcp2:

Gene SymbolEntrez IDGene Name
Tfcp2 ENSMUSG00000009733.8 Tfcp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfcp2mm10_v2_chr15_-_100551959_100552010-0.233.7e-01Click!


Activity profile for motif Tfcp2.

activity profile for motif Tfcp2


Sorted Z-values histogram for motif Tfcp2

Sorted Z-values for motif Tfcp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfcp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_87156127 8.613 ENSMUST00000160810.1
 Ecel1
endothelin converting enzyme-like 1
chr6_+_5390387 8.204 ENSMUST00000183358.1
 Asb4
ankyrin repeat and SOCS box-containing 4
chr11_-_89302545 6.061 ENSMUST00000061728.3
 Nog
noggin
chr16_-_26989974 6.048 ENSMUST00000089832.4
 Gmnc
geminin coiled-coil domain containing
chr8_+_57511833 5.995 ENSMUST00000067925.6
 Hmgb2
high mobility group box 2
chr1_+_107511489 5.875 ENSMUST00000064916.2
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr1_+_107511416 5.662 ENSMUST00000009356.4
 Serpinb2
serine (or cysteine) peptidase inhibitor, clade B, member 2
chr11_-_22001605 5.313 ENSMUST00000006071.7
 Otx1
orthodenticle homolog 1 (Drosophila)
chr8_+_69822429 5.236 ENSMUST00000164890.1
ENSMUST00000034325.4
 Lpar2

lysophosphatidic acid receptor 2

chr2_-_166155272 4.911 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr14_-_21989475 4.533 ENSMUST00000043409.7
 Zfp503
zinc finger protein 503
chr12_+_24708984 4.448 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr6_+_56017489 4.435 ENSMUST00000052827.4
 Ppp1r17
protein phosphatase 1, regulatory subunit 17
chr10_-_42583628 4.372 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr2_-_102186322 4.295 ENSMUST00000111222.1
ENSMUST00000058790.5
 Ldlrad3

low density lipoprotein receptor class A domain containing 3

chr5_+_92809372 4.245 ENSMUST00000113054.2
 Shroom3
shroom family member 3
chr2_-_166155624 4.172 ENSMUST00000109249.2
 Sulf2
sulfatase 2
chr1_-_131097535 4.020 ENSMUST00000016672.4
 Mapkapk2
MAP kinase-activated protein kinase 2
chr18_+_60925644 4.013 ENSMUST00000115297.1
 Camk2a
calcium/calmodulin-dependent protein kinase II alpha
chrX_+_56779437 4.011 ENSMUST00000114773.3
 Fhl1
four and a half LIM domains 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 124 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.0 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.2 9.4 GO:0006270 DNA replication initiation(GO:0006270)
2.3 9.1 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.7 8.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.6 7.8 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.2 7.5 GO:0003016 respiratory system process(GO:0003016)
1.5 6.1 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.9 6.0 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.5 5.6 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.7 5.3 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.2 5.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.2 4.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
1.5 4.5 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.2 4.5 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.9 4.4 GO:0021764 amygdala development(GO:0021764)
1.4 4.3 GO:0098974 postsynaptic actin cytoskeleton organization(GO:0098974)
0.1 4.2 GO:0002066 columnar/cuboidal epithelial cell development(GO:0002066)
1.3 4.0 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
1.0 4.0 GO:1902724 positive regulation of skeletal muscle satellite cell proliferation(GO:1902724) positive regulation of growth factor dependent skeletal muscle satellite cell proliferation(GO:1902728)
0.7 4.0 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) macropinocytosis(GO:0044351)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 29.4 GO:0005615 extracellular space(GO:0005615)
1.6 8.2 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
2.6 7.8 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.0 6.2 GO:0005912 adherens junction(GO:0005912)
0.0 6.0 GO:0000793 condensed chromosome(GO:0000793)
0.7 5.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 5.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 5.0 GO:0005813 centrosome(GO:0005813)
0.5 4.7 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 4.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 4.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 4.1 GO:0030139 endocytic vesicle(GO:0030139)
0.8 4.0 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 3.6 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.5 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.5 3.4 GO:0031298 replication fork protection complex(GO:0031298)
0.8 3.3 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.8 3.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 3.2 GO:0005923 bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0 3.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 94 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
1.0 11.8 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.3 11.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.8 9.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 9.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.6 8.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 7.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 7.3 GO:0048487 beta-tubulin binding(GO:0048487)
1.0 6.1 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 6.1 GO:0019955 cytokine binding(GO:0019955)
0.5 5.6 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 4.7 GO:0030165 PDZ domain binding(GO:0030165)
0.4 4.4 GO:0008199 ferric iron binding(GO:0008199)
0.1 4.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
1.4 4.3 GO:0098973 structural constituent of synapse(GO:0098918) structural constituent of postsynaptic actin cytoskeleton(GO:0098973)
0.1 4.2 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 4.1 GO:0044325 ion channel binding(GO:0044325)
0.8 4.0 GO:0035174 histone serine kinase activity(GO:0035174)
0.4 4.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 3.7 GO:0000900 translation repressor activity, nucleic acid binding(GO:0000900)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 19.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 11.0 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.1 9.0 PID_E2F_PATHWAY E2F transcription factor network
0.3 7.8 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.2 7.7 PID_AURORA_A_PATHWAY Aurora A signaling
0.1 7.4 PID_BMP_PATHWAY BMP receptor signaling
0.1 5.8 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.1 5.2 PID_LYSOPHOSPHOLIPID_PATHWAY LPA receptor mediated events
0.2 4.0 ST_STAT3_PATHWAY STAT3 Pathway
0.1 3.1 PID_HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 3.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.1 2.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 2.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.4 PID_RETINOIC_ACID_PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.4 NABA_SECRETED_FACTORS Genes encoding secreted soluble factors
0.1 2.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.1 1.9 PID_S1P_S1P1_PATHWAY S1P1 pathway
0.0 1.7 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 1.7 PID_AR_PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 7.8 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.2 7.4 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 7.4 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)
0.0 7.3 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 6.6 REACTOME_PREFOLDIN_MEDIATED_TRANSFER_OF_SUBSTRATE_TO_CCT_TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.3 6.5 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.1 6.5 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 6.1 REACTOME_TRANSLATION Genes involved in Translation
0.4 6.0 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 6.0 REACTOME_HEMOSTASIS Genes involved in Hemostasis
0.3 5.6 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 4.8 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.2 4.6 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.3 4.0 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.1 4.0 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0 3.5 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.3 3.4 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 3.3 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Activation of the pre-replicative complex
0.1 3.1 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 2.6 REACTOME_DNA_REPAIR Genes involved in DNA Repair