Motif ID: Foxk1_Foxj1

Z-value: 0.946

Transcription factors associated with Foxk1_Foxj1:

Gene SymbolEntrez IDGene Name
Foxj1 ENSMUSG00000034227.7 Foxj1
Foxk1 ENSMUSG00000056493.8 Foxk1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Foxj1mm10_v2_chr11_-_116335384_1163353990.771.6e-04Click!
Foxk1mm10_v2_chr5_+_142401484_142401532-0.484.4e-02Click!


Activity profile for motif Foxk1_Foxj1.

activity profile for motif Foxk1_Foxj1


Sorted Z-values histogram for motif Foxk1_Foxj1

Sorted Z-values for motif Foxk1_Foxj1



Network of associatons between targets according to the STRING database.



First level regulatory network of Foxk1_Foxj1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_92165159 2.992 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr4_-_154097105 2.473 ENSMUST00000105643.1
ENSMUST00000133533.1
ENSMUST00000097762.4
 Trp73


transformation related protein 73


chr4_-_55532453 2.430 ENSMUST00000132746.1
ENSMUST00000107619.2
 Klf4

Kruppel-like factor 4 (gut)

chr11_+_119022962 2.423 ENSMUST00000026662.7
 Cbx2
chromobox 2
chr10_+_97482350 2.364 ENSMUST00000163448.2
 Dcn
decorin
chr10_-_37138863 2.164 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chr10_-_92164666 2.125 ENSMUST00000183123.1
ENSMUST00000182033.1
 Rmst

rhabdomyosarcoma 2 associated transcript (non-coding RNA)

chr9_-_100506844 2.097 ENSMUST00000112874.3
 Nck1
non-catalytic region of tyrosine kinase adaptor protein 1
chr1_+_110099295 1.915 ENSMUST00000134301.1
 Cdh7
cadherin 7, type 2
chr1_+_45311538 1.858 ENSMUST00000087883.6
 Col3a1
collagen, type III, alpha 1
chr18_-_62756275 1.832 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chrX_+_56786527 1.690 ENSMUST00000144600.1
 Fhl1
four and a half LIM domains 1
chr1_-_72212249 1.669 ENSMUST00000048860.7
 Mreg
melanoregulin
chr3_+_131110350 1.640 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr12_-_10900296 1.439 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr1_-_144177259 1.419 ENSMUST00000111941.1
ENSMUST00000052375.1
 Rgs13

regulator of G-protein signaling 13

chr2_+_164486455 1.375 ENSMUST00000069385.8
ENSMUST00000143690.1
 Dbndd2

dysbindin (dystrobrevin binding protein 1) domain containing 2

chr17_+_9422060 1.346 ENSMUST00000076982.6
 Gm17728
predicted gene, 17728
chr16_-_22161450 1.315 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr10_+_4611971 1.298 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 163 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.5 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.8 2.4 GO:0014738 regulation of muscle hyperplasia(GO:0014738) muscle hyperplasia(GO:0014900)
0.3 2.4 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.7 2.1 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.0 2.0 GO:0045137 development of primary sexual characteristics(GO:0045137)
0.4 1.9 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 1.8 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.1 1.8 GO:0034390 smooth muscle cell apoptotic process(GO:0034390) regulation of smooth muscle cell apoptotic process(GO:0034391)
0.0 1.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.7 GO:0032402 melanosome transport(GO:0032402) anagen(GO:0042640)
0.5 1.6 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 1.5 GO:0071459 protein localization to chromosome, centromeric region(GO:0071459)
0.0 1.5 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.5 1.4 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 1.4 GO:0021670 lateral ventricle development(GO:0021670)
0.0 1.4 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.3 1.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 1.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.4 1.1 GO:1990523 bone regeneration(GO:1990523)
0.1 1.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 79 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0005667 transcription factor complex(GO:0005667)
0.2 4.3 GO:0098644 complex of collagen trimers(GO:0098644)
0.1 2.9 GO:0097546 ciliary base(GO:0097546)
0.1 2.4 GO:0035102 PRC1 complex(GO:0035102)
0.1 2.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.7 2.2 GO:0042585 germinal vesicle(GO:0042585)
0.2 2.1 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 2.1 GO:0070469 respiratory chain(GO:0070469)
0.1 1.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.4 1.6 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.1 1.6 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 1.5 GO:0005902 microvillus(GO:0005902)
0.2 1.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.2 1.2 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 1.2 GO:0044295 axonal growth cone(GO:0044295)
0.2 1.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.1 1.1 GO:0031527 filopodium membrane(GO:0031527)
0.0 1.1 GO:0002102 podosome(GO:0002102)
0.0 1.1 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.1 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 122 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.0 GO:0035064 methylated histone binding(GO:0035064)
0.5 2.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 2.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.5 2.4 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 2.2 GO:0005518 collagen binding(GO:0005518)
0.3 2.1 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 2.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 2.0 GO:0008186 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.1 1.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 1.9 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 1.5 GO:0004386 helicase activity(GO:0004386)
0.2 1.4 GO:0048101 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 1.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 1.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 1.2 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 1.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.1 GO:0001671 ATPase activator activity(GO:0001671)
0.2 1.0 GO:0003681 bent DNA binding(GO:0003681)
0.1 1.0 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)

Gene overrepresentation in C2:CP category:

Showing 1 to 17 of 17 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.4 PID_FRA_PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.1 PID_ARF6_PATHWAY Arf6 signaling events
0.1 2.0 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 1.9 NABA_COLLAGENS Genes encoding collagen proteins
0.0 1.5 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.3 PID_ATR_PATHWAY ATR signaling pathway
0.0 1.3 PID_AURORA_B_PATHWAY Aurora B signaling
0.0 1.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.8 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.6 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.0 0.6 PID_AR_TF_PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.5 PID_RET_PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.3 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.4 REACTOME_CS_DS_DEGRADATION Genes involved in CS/DS degradation
0.1 2.4 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.1 2.4 REACTOME_SYNTHESIS_SECRETION_AND_DEACYLATION_OF_GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 2.4 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.3 2.2 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.7 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.1 1.6 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.1 1.5 REACTOME_KINESINS Genes involved in Kinesins
0.0 1.5 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.5 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.5 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 1.4 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 1.4 REACTOME_CGMP_EFFECTS Genes involved in cGMP effects
0.0 1.3 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 1.3 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 1.1 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.0 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT Genes involved in Respiratory electron transport
0.0 0.9 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.0 0.9 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 0.8 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism