Motif ID: Pknox2_Pknox1

Z-value: 0.751

Transcription factors associated with Pknox2_Pknox1:

Gene SymbolEntrez IDGene Name
Pknox1 ENSMUSG00000006705.6 Pknox1
Pknox2 ENSMUSG00000035934.9 Pknox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pknox2mm10_v2_chr9_-_37147257_371473230.253.2e-01Click!
Pknox1mm10_v2_chr17_+_31564749_315648540.048.8e-01Click!


Activity profile for motif Pknox2_Pknox1.

activity profile for motif Pknox2_Pknox1


Sorted Z-values histogram for motif Pknox2_Pknox1

Sorted Z-values for motif Pknox2_Pknox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 122 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_113758638 1.648 ENSMUST00000099575.3
 Grem1
gremlin 1
chr15_-_100599864 1.093 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr18_+_49832622 1.071 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr16_-_11176056 1.033 ENSMUST00000142389.1
ENSMUST00000138185.1
 Zc3h7a

zinc finger CCCH type containing 7 A

chr5_-_138619653 1.019 ENSMUST00000129832.1
 Zfp68
zinc finger protein 68
chr9_+_123366921 0.925 ENSMUST00000038863.7
 Lars2
leucyl-tRNA synthetase, mitochondrial
chr7_-_131410325 0.900 ENSMUST00000154602.1
 Ikzf5
IKAROS family zinc finger 5
chr9_-_44134481 0.866 ENSMUST00000180670.1
 Gm10687
predicted gene 10687
chr13_+_63815240 0.785 ENSMUST00000021926.5
ENSMUST00000095724.3
ENSMUST00000143449.1
ENSMUST00000067821.5
 Ercc6l2



excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2



chr9_+_113930934 0.753 ENSMUST00000084885.5
ENSMUST00000009885.7
 Ubp1

upstream binding protein 1

chr2_-_31141802 0.739 ENSMUST00000073879.5
ENSMUST00000100208.2
ENSMUST00000100207.2
ENSMUST00000113555.1
ENSMUST00000075326.4
ENSMUST00000113552.2
ENSMUST00000136181.1
 Fnbp1






formin binding protein 1






chr3_-_67375163 0.683 ENSMUST00000166353.1
 Gm17402
predicted gene, 17402
chr1_-_52727457 0.632 ENSMUST00000156876.1
ENSMUST00000087701.3
 Mfsd6

major facilitator superfamily domain containing 6

chr5_+_150673739 0.622 ENSMUST00000016569.4
ENSMUST00000038900.8
 Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chr5_-_109558957 0.599 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr14_+_54640952 0.571 ENSMUST00000169818.2
 Gm17606
predicted gene, 17606
chr17_-_66077022 0.561 ENSMUST00000150766.1
ENSMUST00000038116.5
 Ankrd12

ankyrin repeat domain 12

chr7_-_131410495 0.561 ENSMUST00000121033.1
ENSMUST00000046306.8
 Ikzf5

IKAROS family zinc finger 5

chr8_+_20136455 0.538 ENSMUST00000179299.1
ENSMUST00000096485.4
 Gm21811

predicted gene, 21811

chr5_-_25498702 0.530 ENSMUST00000173073.1
ENSMUST00000045291.7
 Kmt2c

lysine (K)-specific methyltransferase 2C


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 1.6 GO:1901228 regulation of osteoclast proliferation(GO:0090289) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228) negative regulation of bone development(GO:1903011)
0.2 1.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 1.1 GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.9 GO:0032543 mitochondrial translation(GO:0032543)
0.0 0.8 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 0.6 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.0 0.6 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.5 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.0 0.5 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.1 0.4 GO:1904580 quinolinate biosynthetic process(GO:0019805) regulation of intracellular mRNA localization(GO:1904580)
0.1 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.4 GO:0042701 progesterone secretion(GO:0042701)
0.1 0.4 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.4 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
0.1 0.4 GO:1901525 negative regulation of macromitophagy(GO:1901525) regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.1 0.4 GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300)
0.1 0.4 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.4 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.0 0.4 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.6 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.4 GO:0071953 elastic fiber(GO:0071953)
0.0 0.4 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.4 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.2 GO:0098536 deuterosome(GO:0098536)
0.0 0.2 GO:0031415 NatA complex(GO:0031415)
0.0 0.0 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.6 GO:0036122 BMP binding(GO:0036122)
0.3 1.2 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.1 0.9 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.5 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.4 GO:0004092 carnitine O-acetyltransferase activity(GO:0004092)
0.1 0.4 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.4 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.4 GO:0034452 dynactin binding(GO:0034452)
0.0 0.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.4 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.4 GO:0071949 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) FAD binding(GO:0071949)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.4 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 0.2 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.0 0.2 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)

Gene overrepresentation in C2:CP category:

Showing 1 to 3 of 3 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.9 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.4 REACTOME_SYNTHESIS_SECRETION_AND_INACTIVATION_OF_GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.4 REACTOME_SIGNALING_BY_NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME_CIRCADIAN_REPRESSION_OF_EXPRESSION_BY_REV_ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.4 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism