Motif ID: Vsx2_Dlx3

Z-value: 1.274

Transcription factors associated with Vsx2_Dlx3:

Gene SymbolEntrez IDGene Name
Dlx3 ENSMUSG00000001510.7 Dlx3
Vsx2 ENSMUSG00000021239.6 Vsx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vsx2mm10_v2_chr12_+_84569762_84569840-0.155.5e-01Click!





Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx2_Dlx3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_139543889 23.886 ENSMUST00000174792.1
ENSMUST00000031523.8
Uncx

UNC homeobox

chr6_-_23248264 13.816 ENSMUST00000031709.5
Fezf1
Fez family zinc finger 1
chr2_-_168767136 7.941 ENSMUST00000029061.5
ENSMUST00000103074.1
Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 6.111 ENSMUST00000075044.3
Sall4
sal-like 4 (Drosophila)
chr3_-_154328634 5.780 ENSMUST00000167744.1
Lhx8
LIM homeobox protein 8
chr3_-_116253467 4.576 ENSMUST00000090473.5
Gpr88
G-protein coupled receptor 88
chr3_+_159839729 4.513 ENSMUST00000068952.5
Wls
wntless homolog (Drosophila)
chr17_-_70853482 4.417 ENSMUST00000118283.1
Tgif1
TGFB-induced factor homeobox 1
chr3_-_79841729 4.276 ENSMUST00000168038.1
Tmem144
transmembrane protein 144
chr14_-_48662740 4.118 ENSMUST00000122009.1
Otx2
orthodenticle homolog 2 (Drosophila)
chr12_-_56535047 3.728 ENSMUST00000178477.2
Nkx2-1
NK2 homeobox 1
chr7_-_49636847 3.012 ENSMUST00000032717.6
Dbx1
developing brain homeobox 1
chr17_+_43952999 2.813 ENSMUST00000177857.1
Rcan2
regulator of calcineurin 2
chr6_-_147264124 2.514 ENSMUST00000052296.6
Pthlh
parathyroid hormone-like peptide
chr9_-_79977782 2.383 ENSMUST00000093811.4
Filip1
filamin A interacting protein 1
chr3_+_55782500 2.226 ENSMUST00000075422.4
Mab21l1
mab-21-like 1 (C. elegans)
chrM_+_7005 2.189 ENSMUST00000082405.1
mt-Co2
mitochondrially encoded cytochrome c oxidase II
chrX_-_60893430 2.141 ENSMUST00000135107.2
Sox3
SRY-box containing gene 3
chr7_+_144838590 2.136 ENSMUST00000105898.1
Fgf3
fibroblast growth factor 3
chr14_-_12345847 1.960 ENSMUST00000022262.4
Fezf2
Fez family zinc finger 2
chr8_-_57653023 1.937 ENSMUST00000034021.5
Galnt7
UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 7
chr5_-_98566762 1.933 ENSMUST00000086912.4
1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr9_+_119063429 1.858 ENSMUST00000141185.1
ENSMUST00000126251.1
ENSMUST00000136561.1
Vill


villin-like


chr3_-_88410295 1.740 ENSMUST00000056370.7
Pmf1
polyamine-modulated factor 1
chr10_+_128337761 1.705 ENSMUST00000005826.7
Cs
citrate synthase
chr1_+_109983737 1.671 ENSMUST00000172005.1
Cdh7
cadherin 7, type 2
chr8_-_61902669 1.668 ENSMUST00000121785.1
ENSMUST00000034057.7
Palld

palladin, cytoskeletal associated protein

chr18_+_82914632 1.663 ENSMUST00000071233.6
Zfp516
zinc finger protein 516
chr14_-_122451109 1.639 ENSMUST00000081580.2
Gm5089
predicted gene 5089
chr10_-_6980376 1.587 ENSMUST00000105617.1
Ipcef1
interaction protein for cytohesin exchange factors 1
chr8_-_45382198 1.558 ENSMUST00000093526.6
Fam149a
family with sequence similarity 149, member A
chr2_+_109917639 1.372 ENSMUST00000046548.7
ENSMUST00000111037.2
Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr17_-_70998010 1.303 ENSMUST00000024846.6
Myl12a
myosin, light chain 12A, regulatory, non-sarcomeric
chr1_+_10993452 1.272 ENSMUST00000027056.5
Prex2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr11_-_102579461 1.238 ENSMUST00000107081.1
Gm11627
predicted gene 11627
chr4_+_62583568 1.218 ENSMUST00000098031.3
Rgs3
regulator of G-protein signaling 3
chr4_-_132510493 1.208 ENSMUST00000030724.8
Sesn2
sestrin 2
chr9_-_106891401 1.190 ENSMUST00000069036.7
Manf
mesencephalic astrocyte-derived neurotrophic factor
chr17_+_17402672 1.137 ENSMUST00000115576.2
Lix1
limb expression 1 homolog (chicken)
chr6_+_73248382 1.099 ENSMUST00000064740.6
Suclg1
succinate-CoA ligase, GDP-forming, alpha subunit
chr13_-_102906046 1.046 ENSMUST00000171791.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102905740 1.043 ENSMUST00000167462.1
Mast4
microtubule associated serine/threonine kinase family member 4
chr11_-_102185239 0.988 ENSMUST00000021297.5
Lsm12
LSM12 homolog (S. cerevisiae)
chr4_+_8690399 0.966 ENSMUST00000127476.1
Chd7
chromodomain helicase DNA binding protein 7
chr9_+_75775355 0.961 ENSMUST00000012281.7
Bmp5
bone morphogenetic protein 5
chr5_-_138187177 0.944 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr13_-_100616911 0.938 ENSMUST00000168772.1
ENSMUST00000163163.1
ENSMUST00000022137.7
Marveld2


MARVEL (membrane-associating) domain containing 2


chr11_-_102579071 0.914 ENSMUST00000107080.1
Gm11627
predicted gene 11627
chr12_+_55598917 0.904 ENSMUST00000051857.3
Insm2
insulinoma-associated 2
chr1_-_79440039 0.882 ENSMUST00000049972.4
Scg2
secretogranin II
chr2_+_9882622 0.861 ENSMUST00000114919.1
4930412O13Rik
RIKEN cDNA 4930412O13 gene
chr4_-_129261394 0.819 ENSMUST00000145261.1
C77080
expressed sequence C77080
chr3_-_130730310 0.803 ENSMUST00000062601.7
Rpl34
ribosomal protein L34
chr11_+_94327984 0.796 ENSMUST00000107818.2
ENSMUST00000051221.6
Ankrd40

ankyrin repeat domain 40

chr9_-_71163224 0.795 ENSMUST00000074465.2
Aqp9
aquaporin 9
chr1_-_78968079 0.789 ENSMUST00000049117.5
Gm5830
predicted pseudogene 5830
chr1_-_72874877 0.778 ENSMUST00000027377.8
Igfbp5
insulin-like growth factor binding protein 5
chr11_-_33203588 0.774 ENSMUST00000037746.6
Tlx3
T cell leukemia, homeobox 3
chr1_-_172027269 0.762 ENSMUST00000027837.6
ENSMUST00000111264.1
Vangl2

vang-like 2 (van gogh, Drosophila)

chr3_-_130730375 0.751 ENSMUST00000079085.6
Rpl34
ribosomal protein L34
chr5_+_138187485 0.720 ENSMUST00000110934.2
Cnpy4
canopy 4 homolog (zebrafish)
chr1_-_190170671 0.714 ENSMUST00000175916.1
Prox1
prospero-related homeobox 1
chr12_+_108605757 0.652 ENSMUST00000109854.2
Evl
Ena-vasodilator stimulated phosphoprotein
chr18_-_66022580 0.652 ENSMUST00000143990.1
Lman1
lectin, mannose-binding, 1
chr17_-_35697971 0.615 ENSMUST00000146472.1
Ddr1
discoidin domain receptor family, member 1
chr1_-_182282738 0.581 ENSMUST00000035295.5
Degs1
degenerative spermatocyte homolog 1 (Drosophila)
chr2_-_27475622 0.548 ENSMUST00000138693.1
ENSMUST00000113941.2
ENSMUST00000077737.6
Brd3


bromodomain containing 3


chr9_-_21312255 0.544 ENSMUST00000115433.3
ENSMUST00000003397.7
Ap1m2

adaptor protein complex AP-1, mu 2 subunit

chr10_+_73821857 0.543 ENSMUST00000177128.1
ENSMUST00000064562.7
ENSMUST00000129404.2
ENSMUST00000105426.3
ENSMUST00000131321.2
ENSMUST00000126920.2
ENSMUST00000147189.2
ENSMUST00000105424.3
ENSMUST00000092420.6
ENSMUST00000105429.3
ENSMUST00000131724.2
ENSMUST00000152655.2
ENSMUST00000151116.2
ENSMUST00000155701.2
ENSMUST00000152819.2
ENSMUST00000125517.2
ENSMUST00000124046.1
ENSMUST00000149977.2
ENSMUST00000146682.1
ENSMUST00000177107.1
Pcdh15



















protocadherin 15



















chr4_-_110292719 0.509 ENSMUST00000106601.1
Elavl4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr4_+_99955715 0.491 ENSMUST00000102783.4
Pgm2
phosphoglucomutase 2
chr4_-_45532470 0.467 ENSMUST00000147448.1
Shb
src homology 2 domain-containing transforming protein B
chr7_-_116031047 0.465 ENSMUST00000106612.1
Sox6
SRY-box containing gene 6
chr4_+_5724304 0.460 ENSMUST00000108380.1
Fam110b
family with sequence similarity 110, member B
chr6_+_63255971 0.446 ENSMUST00000159561.1
ENSMUST00000095852.3
Grid2

glutamate receptor, ionotropic, delta 2

chr6_+_30541582 0.437 ENSMUST00000096066.4
Cpa2
carboxypeptidase A2, pancreatic
chr7_-_5014645 0.414 ENSMUST00000165320.1
Fiz1
Flt3 interacting zinc finger protein 1
chr5_-_137531952 0.404 ENSMUST00000140139.1
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr17_-_24073479 0.399 ENSMUST00000017090.5
Kctd5
potassium channel tetramerisation domain containing 5
chr1_+_87183310 0.392 ENSMUST00000044533.8
Prss56
protease, serine 56
chr8_-_84846860 0.389 ENSMUST00000003912.6
Calr
calreticulin
chrX_+_107255878 0.360 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
Gpr174


G protein-coupled receptor 174


chr2_+_49787675 0.336 ENSMUST00000028103.6
Lypd6b
LY6/PLAUR domain containing 6B
chr11_+_60537978 0.336 ENSMUST00000044250.3
Alkbh5
alkB, alkylation repair homolog 5 (E. coli)
chr4_-_83285141 0.335 ENSMUST00000150522.1
Ttc39b
tetratricopeptide repeat domain 39B
chr10_-_53647080 0.333 ENSMUST00000169866.1
Fam184a
family with sequence similarity 184, member A
chr2_-_121235689 0.325 ENSMUST00000142400.1
Trp53bp1
transformation related protein 53 binding protein 1
chr11_+_62077018 0.321 ENSMUST00000092415.5
Specc1
sperm antigen with calponin homology and coiled-coil domains 1
chr5_-_137531204 0.303 ENSMUST00000150063.2
Gnb2
guanine nucleotide binding protein (G protein), beta 2
chr1_-_84839304 0.294 ENSMUST00000027421.6
Trip12
thyroid hormone receptor interactor 12
chr9_+_94669876 0.293 ENSMUST00000033463.9
Slc9a9
solute carrier family 9 (sodium/hydrogen exchanger), member 9
chr5_+_27261916 0.281 ENSMUST00000101471.3
Dpp6
dipeptidylpeptidase 6
chr2_-_79456750 0.260 ENSMUST00000041099.4
Neurod1
neurogenic differentiation 1
chr18_+_37300799 0.257 ENSMUST00000051754.1
Pcdhb3
protocadherin beta 3
chr1_-_140183283 0.245 ENSMUST00000111977.1
Cfh
complement component factor h
chr7_-_115846080 0.232 ENSMUST00000166207.1
Sox6
SRY-box containing gene 6
chr3_-_50443603 0.232 ENSMUST00000029297.4
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr1_-_140183404 0.204 ENSMUST00000066859.6
ENSMUST00000111976.2
Cfh

complement component factor h

chr1_-_172027251 0.204 ENSMUST00000138714.1
Vangl2
vang-like 2 (van gogh, Drosophila)
chr12_-_31713873 0.196 ENSMUST00000057783.4
ENSMUST00000174480.2
ENSMUST00000176710.1
Gpr22


G protein-coupled receptor 22


chr4_-_41464816 0.188 ENSMUST00000108055.2
ENSMUST00000154535.1
ENSMUST00000030148.5
Kif24


kinesin family member 24


chr15_+_44428073 0.157 ENSMUST00000060652.3
Eny2
enhancer of yellow 2 homolog (Drosophila)
chr2_-_69712461 0.155 ENSMUST00000102706.3
ENSMUST00000073152.6
Fastkd1

FAST kinase domains 1

chr16_+_34690548 0.145 ENSMUST00000023532.6
Ccdc14
coiled-coil domain containing 14
chr15_+_98571004 0.136 ENSMUST00000023728.6
4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr14_+_32321987 0.126 ENSMUST00000022480.7
Ogdhl
oxoglutarate dehydrogenase-like
chr16_-_89818338 0.106 ENSMUST00000164263.2
Tiam1
T cell lymphoma invasion and metastasis 1
chr3_+_122274371 0.081 ENSMUST00000035776.8
Dnttip2
deoxynucleotidyltransferase, terminal, interacting protein 2
chr2_+_36230426 0.074 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr11_-_82890541 0.061 ENSMUST00000092844.6
ENSMUST00000021033.9
ENSMUST00000018985.8
Rad51d


RAD51 homolog D


chr2_-_71055534 0.054 ENSMUST00000090849.5
ENSMUST00000100037.2
ENSMUST00000112186.2
Mettl8


methyltransferase like 8


chr18_-_75697639 0.050 ENSMUST00000165559.1
Ctif
CBP80/20-dependent translation initiation factor
chr10_+_127420867 0.038 ENSMUST00000064793.6
R3hdm2
R3H domain containing 2
chr7_-_100855403 0.034 ENSMUST00000156855.1
Relt
RELT tumor necrosis factor receptor
chr15_+_81744848 0.023 ENSMUST00000109554.1
Zc3h7b
zinc finger CCCH type containing 7B
chr19_+_5088534 0.016 ENSMUST00000025811.4
Yif1a
Yip1 interacting factor homolog A (S. cerevisiae)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 23.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
2.6 15.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.5 4.5 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
1.2 3.7 GO:0021759 globus pallidus development(GO:0021759)
1.1 4.6 GO:0061743 motor learning(GO:0061743)
1.0 4.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.8 14.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.5 2.5 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.5 1.4 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.4 1.2 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.4 1.2 GO:0002014 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014)
0.4 2.5 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.3 4.3 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.3 1.0 GO:0060489 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.3 4.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 1.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 0.7 GO:0090425 hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.2 0.9 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.2 3.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 2.6 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.1 1.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.1 1.7 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 0.8 GO:0032782 bile acid secretion(GO:0032782)
0.1 0.7 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 2.1 GO:0007530 sex determination(GO:0007530)
0.1 0.7 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.3 GO:1902915 negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1 1.7 GO:0071803 keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803)
0.1 0.3 GO:0060729 intestinal epithelial structure maintenance(GO:0060729)
0.1 0.3 GO:0035553 oxidative single-stranded RNA demethylation(GO:0035553)
0.1 5.7 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.1 0.4 GO:0045919 complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919)
0.1 0.5 GO:0019388 galactose catabolic process(GO:0019388)
0.1 0.5 GO:0050957 equilibrioception(GO:0050957)
0.1 0.5 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.8 GO:0048665 neuron fate specification(GO:0048665)
0.1 0.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 1.7 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 1.9 GO:0051693 actin filament capping(GO:0051693)
0.0 1.9 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.0 2.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.0 0.1 GO:1903977 positive regulation of Schwann cell migration(GO:1900149) positive regulation of glial cell migration(GO:1903977)
0.0 1.1 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.4 GO:1904861 prepulse inhibition(GO:0060134) excitatory synapse assembly(GO:1904861)
0.0 0.3 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 1.3 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.9 GO:0061028 establishment of endothelial barrier(GO:0061028)
0.0 0.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.4 GO:1900006 positive regulation of dendrite development(GO:1900006)
0.0 0.1 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.0 0.2 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.7 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 0.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 5.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.3 1.7 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.2 1.0 GO:0060187 cell pole(GO:0060187)
0.2 0.8 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 1.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 0.9 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.2 2.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 4.5 GO:0032590 dendrite membrane(GO:0032590)
0.1 14.1 GO:0000792 heterochromatin(GO:0000792)
0.1 1.3 GO:0016460 myosin II complex(GO:0016460)
0.1 0.9 GO:0031045 dense core granule(GO:0031045)
0.0 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 0.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.7 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 1.7 GO:0002102 podosome(GO:0002102)
0.0 0.4 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.2 GO:0000124 SAGA complex(GO:0000124)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.1 GO:0045252 dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.0 0.1 GO:0060091 kinocilium(GO:0060091)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.4 2.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.4 1.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.3 3.7 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.3 1.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 2.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.2 1.2 GO:0070728 leucine binding(GO:0070728)
0.2 4.4 GO:0070410 co-SMAD binding(GO:0070410)
0.2 0.8 GO:0015254 glycerol channel activity(GO:0015254)
0.2 0.6 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
0.1 1.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 0.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.1 0.4 GO:0001851 complement component C3b binding(GO:0001851)
0.1 1.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 4.3 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.1 2.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.0 GO:0070700 BMP receptor binding(GO:0070700)
0.1 0.3 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.1 0.7 GO:0050693 LBD domain binding(GO:0050693)
0.1 0.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 2.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.2 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1 10.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.7 GO:0005522 profilin binding(GO:0005522)
0.1 0.7 GO:0005537 mannose binding(GO:0005537)
0.0 0.9 GO:0042056 chemoattractant activity(GO:0042056)
0.0 47.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 0.3 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.5 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 4.4 GO:0003774 motor activity(GO:0003774)
0.0 0.4 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 0.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.3 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 2.2 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.0 1.2 GO:0008083 growth factor activity(GO:0008083)
0.0 0.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.0 0.4 GO:0097602 cullin family protein binding(GO:0097602)
0.0 1.3 GO:0035254 glutamate receptor binding(GO:0035254)
0.0 0.4 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 12.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 2.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 1.6 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.1 4.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.0 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.7 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.1 2.8 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 4.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 0.8 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 3.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.7 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.5 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.9 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.7 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis