Motif ID: Vsx2_Dlx3

Z-value: 1.274

Transcription factors associated with Vsx2_Dlx3:

Gene SymbolEntrez IDGene Name
Dlx3 ENSMUSG00000001510.7 Dlx3
Vsx2 ENSMUSG00000021239.6 Vsx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vsx2mm10_v2_chr12_+_84569762_84569840-0.155.5e-01Click!


Activity profile for motif Vsx2_Dlx3.

activity profile for motif Vsx2_Dlx3


Sorted Z-values histogram for motif Vsx2_Dlx3

Sorted Z-values for motif Vsx2_Dlx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Vsx2_Dlx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 23.886 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr6_-_23248264 13.816 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr2_-_168767136 7.941 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr2_-_168767029 6.111 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr3_-_154328634 5.780 ENSMUST00000167744.1
 Lhx8
LIM homeobox protein 8
chr3_-_116253467 4.576 ENSMUST00000090473.5
 Gpr88
G-protein coupled receptor 88
chr3_+_159839729 4.513 ENSMUST00000068952.5
 Wls
wntless homolog (Drosophila)
chr17_-_70853482 4.417 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr3_-_79841729 4.276 ENSMUST00000168038.1
 Tmem144
transmembrane protein 144
chr14_-_48662740 4.118 ENSMUST00000122009.1
 Otx2
orthodenticle homolog 2 (Drosophila)
chr12_-_56535047 3.728 ENSMUST00000178477.2
 Nkx2-1
NK2 homeobox 1
chr7_-_49636847 3.012 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr17_+_43952999 2.813 ENSMUST00000177857.1
 Rcan2
regulator of calcineurin 2
chr6_-_147264124 2.514 ENSMUST00000052296.6
 Pthlh
parathyroid hormone-like peptide
chr9_-_79977782 2.383 ENSMUST00000093811.4
 Filip1
filamin A interacting protein 1
chr3_+_55782500 2.226 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chrM_+_7005 2.189 ENSMUST00000082405.1
 mt-Co2
mitochondrially encoded cytochrome c oxidase II
chrX_-_60893430 2.141 ENSMUST00000135107.2
 Sox3
SRY-box containing gene 3
chr7_+_144838590 2.136 ENSMUST00000105898.1
 Fgf3
fibroblast growth factor 3
chr14_-_12345847 1.960 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 23.9 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
2.6 15.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.8 14.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 5.7 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.3 4.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.1 4.6 GO:0061743 motor learning(GO:0061743)
1.5 4.5 GO:0061357 Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357)
0.3 4.3 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
1.0 4.1 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
1.2 3.7 GO:0021759 globus pallidus development(GO:0021759)
0.2 3.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 2.6 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.5 2.5 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.4 2.5 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.0 2.2 GO:0042773 ATP synthesis coupled electron transport(GO:0042773)
0.1 2.1 GO:0007530 sex determination(GO:0007530)
0.0 1.9 GO:0051693 actin filament capping(GO:0051693)
0.0 1.9 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.2 1.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 1.7 GO:0006107 oxaloacetate metabolic process(GO:0006107)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 25 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 14.1 GO:0000792 heterochromatin(GO:0000792)
1.0 5.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.1 4.5 GO:0032590 dendrite membrane(GO:0032590)
0.2 2.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.3 1.7 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.0 1.7 GO:0002102 podosome(GO:0002102)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 1.3 GO:0016460 myosin II complex(GO:0016460)
0.1 1.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 1.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.2 1.0 GO:0060187 cell pole(GO:0060187)
0.2 0.9 GO:0061689 paranodal junction(GO:0033010) tricellular tight junction(GO:0061689)
0.1 0.9 GO:0031045 dense core granule(GO:0031045)
0.0 0.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.2 0.8 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.7 GO:0033655 host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0 0.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 0.5 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)
0.0 0.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 47.2 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.1 10.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.5 4.5 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.2 4.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 4.4 GO:0003774 motor activity(GO:0003774)
0.1 4.3 GO:0015144 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.3 3.7 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.4 2.6 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3 2.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 2.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.2 GO:0016779 nucleotidyltransferase activity(GO:0016779)
0.1 2.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 1.7 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.1 1.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.1 1.5 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.4 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.3 GO:0035254 glutamate receptor binding(GO:0035254)
0.2 1.2 GO:0070728 leucine binding(GO:0070728)
0.0 1.2 GO:0008083 growth factor activity(GO:0008083)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 12.3 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.4 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.1 3.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 2.6 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 2.5 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.6 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.3 PID_EPHRINB_REV_PATHWAY Ephrin B reverse signaling
0.0 1.0 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway
0.0 0.7 PID_TCPTP_PATHWAY Signaling events mediated by TCPTP
0.0 0.5 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 18 of 18 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.4 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 3.2 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.8 REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 1.9 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.7 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.7 REACTOME_MITOTIC_PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 1.6 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.1 1.5 REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 0.9 REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 0.8 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.8 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.7 REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.7 REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.6 REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.5 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 0.4 REACTOME_REGULATION_OF_COMPLEMENT_CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha