Motif ID: Vsx2_Dlx3
Z-value: 1.274
Transcription factors associated with Vsx2_Dlx3:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
Dlx3 | ENSMUSG00000001510.7 | Dlx3 |
Vsx2 | ENSMUSG00000021239.6 | Vsx2 |
Activity-expression correlation:
Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
---|---|---|---|---|
Vsx2 | mm10_v2_chr12_+_84569762_84569840 | -0.15 | 5.5e-01 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.0 | 23.9 | GO:0035726 | common myeloid progenitor cell proliferation(GO:0035726) |
2.6 | 15.8 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
1.5 | 4.5 | GO:0061357 | Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) positive regulation of Wnt protein secretion(GO:0061357) |
1.2 | 3.7 | GO:0021759 | globus pallidus development(GO:0021759) |
1.1 | 4.6 | GO:0061743 | motor learning(GO:0061743) |
1.0 | 4.1 | GO:0046552 | eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552) |
0.8 | 14.1 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
0.5 | 2.5 | GO:0060648 | mammary gland bud morphogenesis(GO:0060648) |
0.5 | 1.4 | GO:0072204 | cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204) |
0.4 | 1.2 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
0.4 | 1.2 | GO:0002014 | vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure(GO:0002014) |
0.4 | 2.5 | GO:0048752 | semicircular canal morphogenesis(GO:0048752) |
0.3 | 4.3 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
0.3 | 1.0 | GO:0060489 | orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490) |
0.3 | 4.8 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.2 | 1.7 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
0.2 | 0.7 | GO:0090425 | hepatocyte cell migration(GO:0002194) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979) |
0.2 | 0.9 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
0.2 | 3.0 | GO:0021521 | ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573) |
0.1 | 2.6 | GO:0031987 | locomotion involved in locomotory behavior(GO:0031987) |
0.1 | 1.1 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
0.1 | 1.7 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
0.1 | 0.8 | GO:0032782 | bile acid secretion(GO:0032782) |
0.1 | 0.7 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
0.1 | 2.1 | GO:0007530 | sex determination(GO:0007530) |
0.1 | 0.7 | GO:0021780 | oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) |
0.1 | 0.3 | GO:1902915 | negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915) |
0.1 | 1.7 | GO:0071803 | keratinocyte development(GO:0003334) positive regulation of podosome assembly(GO:0071803) |
0.1 | 0.3 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
0.1 | 0.3 | GO:0035553 | oxidative single-stranded RNA demethylation(GO:0035553) |
0.1 | 5.7 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
0.1 | 0.4 | GO:0045919 | complement activation, alternative pathway(GO:0006957) positive regulation of cytolysis(GO:0045919) |
0.1 | 0.5 | GO:0019388 | galactose catabolic process(GO:0019388) |
0.1 | 0.5 | GO:0050957 | equilibrioception(GO:0050957) |
0.1 | 0.5 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
0.1 | 0.8 | GO:0048665 | neuron fate specification(GO:0048665) |
0.1 | 0.6 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
0.0 | 1.7 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
0.0 | 1.9 | GO:0051693 | actin filament capping(GO:0051693) |
0.0 | 1.9 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
0.0 | 2.2 | GO:0042773 | ATP synthesis coupled electron transport(GO:0042773) |
0.0 | 0.1 | GO:1903977 | positive regulation of Schwann cell migration(GO:1900149) positive regulation of glial cell migration(GO:1903977) |
0.0 | 1.1 | GO:0097352 | autophagosome maturation(GO:0097352) |
0.0 | 0.4 | GO:1904861 | prepulse inhibition(GO:0060134) excitatory synapse assembly(GO:1904861) |
0.0 | 0.3 | GO:1990118 | sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118) |
0.0 | 1.3 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
0.0 | 0.9 | GO:0061028 | establishment of endothelial barrier(GO:0061028) |
0.0 | 0.3 | GO:2000042 | negative regulation of double-strand break repair via homologous recombination(GO:2000042) |
0.0 | 0.2 | GO:0089711 | L-glutamate transmembrane transport(GO:0089711) |
0.0 | 0.4 | GO:1900006 | positive regulation of dendrite development(GO:1900006) |
0.0 | 0.1 | GO:0010700 | negative regulation of norepinephrine secretion(GO:0010700) |
0.0 | 0.2 | GO:0061179 | negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179) |
0.0 | 0.7 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
0.0 | 0.1 | GO:0000707 | meiotic DNA recombinase assembly(GO:0000707) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 5.8 | GO:0001674 | female germ cell nucleus(GO:0001674) |
0.3 | 1.7 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
0.2 | 1.0 | GO:0060187 | cell pole(GO:0060187) |
0.2 | 0.8 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
0.2 | 1.1 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
0.2 | 0.9 | GO:0061689 | paranodal junction(GO:0033010) tricellular tight junction(GO:0061689) |
0.2 | 2.2 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
0.1 | 1.2 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
0.1 | 4.5 | GO:0032590 | dendrite membrane(GO:0032590) |
0.1 | 14.1 | GO:0000792 | heterochromatin(GO:0000792) |
0.1 | 1.3 | GO:0016460 | myosin II complex(GO:0016460) |
0.1 | 0.9 | GO:0031045 | dense core granule(GO:0031045) |
0.0 | 0.4 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
0.0 | 0.9 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
0.0 | 0.7 | GO:0033655 | host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655) |
0.0 | 1.7 | GO:0002102 | podosome(GO:0002102) |
0.0 | 0.4 | GO:0042788 | polysomal ribosome(GO:0042788) |
0.0 | 0.2 | GO:0000124 | SAGA complex(GO:0000124) |
0.0 | 1.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
0.0 | 0.7 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
0.0 | 0.1 | GO:0045252 | dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252) |
0.0 | 0.1 | GO:0060091 | kinocilium(GO:0060091) |
0.0 | 0.5 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
0.0 | 0.1 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
0.0 | 0.5 | GO:0032420 | stereocilium(GO:0032420) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 4.5 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
0.4 | 2.6 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
0.4 | 1.1 | GO:0004774 | succinate-CoA ligase activity(GO:0004774) |
0.3 | 3.7 | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) |
0.3 | 1.7 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
0.3 | 2.5 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.2 | 1.2 | GO:0070728 | leucine binding(GO:0070728) |
0.2 | 4.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.2 | 0.8 | GO:0015254 | glycerol channel activity(GO:0015254) |
0.2 | 0.6 | GO:0042284 | sphingolipid delta-4 desaturase activity(GO:0042284) |
0.1 | 1.7 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
0.1 | 0.9 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
0.1 | 1.4 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
0.1 | 0.4 | GO:0001851 | complement component C3b binding(GO:0001851) |
0.1 | 1.9 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
0.1 | 4.3 | GO:0015144 | carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476) |
0.1 | 2.2 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.1 | 0.8 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
0.1 | 1.0 | GO:0070700 | BMP receptor binding(GO:0070700) |
0.1 | 0.3 | GO:0035515 | oxidative RNA demethylase activity(GO:0035515) |
0.1 | 0.7 | GO:0050693 | LBD domain binding(GO:0050693) |
0.1 | 0.5 | GO:0004614 | phosphoglucomutase activity(GO:0004614) |
0.1 | 1.5 | GO:0005104 | fibroblast growth factor receptor binding(GO:0005104) |
0.1 | 0.6 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
0.1 | 2.1 | GO:0001106 | RNA polymerase II transcription corepressor activity(GO:0001106) |
0.1 | 0.2 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
0.1 | 10.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
0.1 | 0.3 | GO:0061649 | ubiquitinated histone binding(GO:0061649) |
0.1 | 0.7 | GO:0005522 | profilin binding(GO:0005522) |
0.1 | 0.7 | GO:0005537 | mannose binding(GO:0005537) |
0.0 | 0.9 | GO:0042056 | chemoattractant activity(GO:0042056) |
0.0 | 47.2 | GO:0043565 | sequence-specific DNA binding(GO:0043565) |
0.0 | 0.3 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
0.0 | 0.5 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
0.0 | 4.4 | GO:0003774 | motor activity(GO:0003774) |
0.0 | 0.4 | GO:0045125 | bioactive lipid receptor activity(GO:0045125) |
0.0 | 0.3 | GO:0099602 | acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602) |
0.0 | 0.1 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
0.0 | 0.3 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
0.0 | 2.2 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
0.0 | 1.2 | GO:0008083 | growth factor activity(GO:0008083) |
0.0 | 0.7 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
0.0 | 0.4 | GO:0097602 | cullin family protein binding(GO:0097602) |
0.0 | 1.3 | GO:0035254 | glutamate receptor binding(GO:0035254) |
0.0 | 0.4 | GO:0050681 | androgen receptor binding(GO:0050681) |
0.0 | 0.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.4 | GO:0017091 | AU-rich element binding(GO:0017091) |
0.0 | 0.5 | GO:0030971 | receptor tyrosine kinase binding(GO:0030971) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 12.3 | PID_BETA_CATENIN_NUC_PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
0.1 | 2.5 | PID_HEDGEHOG_2PATHWAY | Signaling events mediated by the Hedgehog family |
0.1 | 3.7 | PID_HNF3B_PATHWAY | FOXA2 and FOXA3 transcription factor networks |
0.1 | 2.6 | PID_TCR_CALCIUM_PATHWAY | Calcium signaling in the CD4+ TCR pathway |
0.1 | 1.6 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
0.1 | 4.4 | PID_AR_PATHWAY | Coregulation of Androgen receptor activity |
0.0 | 1.3 | PID_EPHRINB_REV_PATHWAY | Ephrin B reverse signaling |
0.0 | 1.0 | PID_WNT_NONCANONICAL_PATHWAY | Noncanonical Wnt signaling pathway |
0.0 | 0.5 | PID_PDGFRA_PATHWAY | PDGFR-alpha signaling pathway |
0.0 | 0.7 | PID_TCPTP_PATHWAY | Signaling events mediated by TCPTP |
Gene overrepresentation in C2:CP:REACTOME category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.5 | REACTOME_FGFR1_LIGAND_BINDING_AND_ACTIVATION | Genes involved in FGFR1 ligand binding and activation |
0.1 | 2.8 | REACTOME_CITRIC_ACID_CYCLE_TCA_CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
0.1 | 4.4 | REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
0.1 | 0.8 | REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS | Genes involved in Passive Transport by Aquaporins |
0.1 | 0.4 | REACTOME_REGULATION_OF_COMPLEMENT_CASCADE | Genes involved in Regulation of Complement cascade |
0.0 | 0.8 | REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
0.0 | 1.7 | REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS | Genes involved in Adherens junctions interactions |
0.0 | 1.9 | REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS | Genes involved in O-linked glycosylation of mucins |
0.0 | 0.4 | REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
0.0 | 0.5 | REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
0.0 | 3.2 | REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
0.0 | 0.7 | REACTOME_GENERATION_OF_SECOND_MESSENGER_MOLECULES | Genes involved in Generation of second messenger molecules |
0.0 | 0.5 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
0.0 | 0.9 | REACTOME_RNA_POL_II_TRANSCRIPTION_PRE_INITIATION_AND_PROMOTER_OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
0.0 | 0.7 | REACTOME_TRANSPORT_TO_THE_GOLGI_AND_SUBSEQUENT_MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
0.0 | 1.7 | REACTOME_MITOTIC_PROMETAPHASE | Genes involved in Mitotic Prometaphase |
0.0 | 1.6 | REACTOME_PEPTIDE_CHAIN_ELONGATION | Genes involved in Peptide chain elongation |
0.0 | 0.6 | REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |