Motif ID: Tcf3

Z-value: 0.960


Transcription factors associated with Tcf3:

Gene SymbolEntrez IDGene Name
Tcf3 ENSMUSG00000020167.8 Tcf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf3mm10_v2_chr10_-_80433615_804336550.672.3e-03Click!


Activity profile for motif Tcf3.

activity profile for motif Tcf3


Sorted Z-values histogram for motif Tcf3

Sorted Z-values for motif Tcf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_28302238 3.751 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chr1_+_74791516 3.120 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr14_-_20181773 2.877 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr12_+_109459843 2.695 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr15_+_34238026 2.643 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr7_+_121707189 2.451 ENSMUST00000065310.2
 1700069B07Rik
RIKEN cDNA 1700069B07 gene
chr19_+_25610533 2.279 ENSMUST00000048935.4
 Dmrt3
doublesex and mab-3 related transcription factor 3
chr6_+_17307272 2.262 ENSMUST00000115454.1
 Cav1
caveolin 1, caveolae protein
chr6_+_17307632 2.246 ENSMUST00000115453.1
 Cav1
caveolin 1, caveolae protein
chr6_-_72235559 2.229 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr13_-_116309639 1.989 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr6_+_29694204 1.985 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr1_+_129273344 1.976 ENSMUST00000073527.6
ENSMUST00000040311.7
 Thsd7b

thrombospondin, type I, domain containing 7B

chr7_-_17056669 1.838 ENSMUST00000037762.4
 Hif3a
hypoxia inducible factor 3, alpha subunit
chr17_-_35703971 1.827 ENSMUST00000148065.1
 Ddr1
discoidin domain receptor family, member 1
chr12_+_110279228 1.789 ENSMUST00000097228.4
 Dio3
deiodinase, iodothyronine type III
chr5_-_98566762 1.787 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chr8_-_122699066 1.784 ENSMUST00000127984.1
 Cbfa2t3
core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)
chr13_-_60177357 1.773 ENSMUST00000065086.4
 Gas1
growth arrest specific 1
chr7_+_19094594 1.757 ENSMUST00000049454.5
 Six5
sine oculis-related homeobox 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 215 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 5.4 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.9 4.5 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.4 4.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.8 3.8 GO:0007386 compartment pattern specification(GO:0007386)
0.4 3.6 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 3.3 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.4 3.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 2.8 GO:0048194 Golgi vesicle budding(GO:0048194)
0.1 2.7 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.1 2.7 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 2.6 GO:0035329 hippo signaling(GO:0035329)
0.3 2.4 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.5 2.2 GO:0060032 notochord regression(GO:0060032)
0.2 2.2 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.7 2.0 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
0.7 2.0 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.1 2.0 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 1.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.3 1.8 GO:0046549 phenol-containing compound catabolic process(GO:0019336) retinal cone cell development(GO:0046549)
0.3 1.8 GO:1903715 regulation of aerobic respiration(GO:1903715)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 102 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 4.5 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 4.5 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.6 GO:0031985 Golgi cisterna(GO:0031985)
0.8 2.4 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.2 2.4 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 2.4 GO:0044295 axonal growth cone(GO:0044295)
0.0 2.4 GO:0005819 spindle(GO:0005819)
0.0 2.3 GO:0000922 spindle pole(GO:0000922)
0.2 2.2 GO:0097542 ciliary tip(GO:0097542)
0.1 2.1 GO:0001891 phagocytic cup(GO:0001891)
0.2 2.0 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 1.7 GO:0016324 apical plasma membrane(GO:0016324)
0.0 1.6 GO:0031225 anchored component of membrane(GO:0031225)
0.3 1.4 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.4 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 4.5 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.5 4.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 4.3 GO:0002039 p53 binding(GO:0002039)
0.1 4.2 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 3.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 3.9 GO:0070888 E-box binding(GO:0070888)
0.1 3.7 GO:0005112 Notch binding(GO:0005112)
0.3 3.6 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 3.6 GO:0005109 frizzled binding(GO:0005109)
0.8 3.2 GO:0050436 microfibril binding(GO:0050436)
0.1 2.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 2.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.5 2.5 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 2.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 2.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.3 2.1 GO:0001849 complement component C1q binding(GO:0001849)
0.3 2.0 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 2.0 GO:0003774 motor activity(GO:0003774)
0.1 1.9 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.4 1.8 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 52 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.2 4.7 PID_WNT_CANONICAL_PATHWAY Canonical Wnt signaling pathway
0.0 3.7 NABA_ECM_GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.2 PID_NOTCH_PATHWAY Notch signaling pathway
0.1 2.7 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 2.6 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.1 2.5 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 2.0 PID_VEGF_VEGFR_PATHWAY VEGF and VEGFR signaling network
0.1 2.0 PID_INTEGRIN1_PATHWAY Beta1 integrin cell surface interactions
0.1 1.8 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.6 PID_FGF_PATHWAY FGF signaling pathway
0.2 1.4 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 1.2 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 1.2 PID_BARD1_PATHWAY BARD1 signaling events
0.0 1.2 PID_FOXO_PATHWAY FoxO family signaling
0.0 1.1 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.0 1.1 PID_IGF1_PATHWAY IGF1 pathway
0.0 1.1 PID_P38_ALPHA_BETA_PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.0 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 0.9 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 5.0 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 4.7 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 4.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.0 3.9 REACTOME_G_ALPHA_I_SIGNALLING_EVENTS Genes involved in G alpha (i) signalling events
0.1 3.7 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.2 3.4 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.0 3.1 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
0.1 2.7 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.5 REACTOME_ERK_MAPK_TARGETS Genes involved in ERK/MAPK targets
0.1 2.2 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 2.0 REACTOME_VEGF_LIGAND_RECEPTOR_INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 1.8 REACTOME_AMINE_DERIVED_HORMONES Genes involved in Amine-derived hormones
0.1 1.8 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 1.6 REACTOME_CA_DEPENDENT_EVENTS Genes involved in Ca-dependent events
0.0 1.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.4 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 1.4 REACTOME_INTERFERON_GAMMA_SIGNALING Genes involved in Interferon gamma signaling
0.0 1.3 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.2 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.2 REACTOME_SMOOTH_MUSCLE_CONTRACTION Genes involved in Smooth Muscle Contraction