Motif ID: E2f2_E2f5

Z-value: 3.815

Transcription factors associated with E2f2_E2f5:

Gene SymbolEntrez IDGene Name
E2f2 ENSMUSG00000018983.9 E2f2
E2f5 ENSMUSG00000027552.8 E2f5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
E2f2mm10_v2_chr4_+_136172367_1361723950.831.7e-05Click!
E2f5mm10_v2_chr3_+_14578609_145786870.814.4e-05Click!


Activity profile for motif E2f2_E2f5.

activity profile for motif E2f2_E2f5


Sorted Z-values histogram for motif E2f2_E2f5

Sorted Z-values for motif E2f2_E2f5



Network of associatons between targets according to the STRING database.



First level regulatory network of E2f2_E2f5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_139543889 31.777 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr7_-_137314394 21.276 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr4_+_136172367 15.906 ENSMUST00000061721.5
 E2f2
E2F transcription factor 2
chr13_-_24761440 12.651 ENSMUST00000176890.1
ENSMUST00000175689.1
 Gmnn

geminin

chr12_+_24708241 12.586 ENSMUST00000020980.5
 Rrm2
ribonucleotide reductase M2
chr13_-_24761861 11.742 ENSMUST00000006898.3
ENSMUST00000110382.2
 Gmnn

geminin

chr8_+_75109528 11.099 ENSMUST00000164309.1
 Mcm5
minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)
chr2_-_157204483 10.981 ENSMUST00000029170.7
 Rbl1
retinoblastoma-like 1 (p107)
chr10_-_69352886 10.720 ENSMUST00000119827.1
ENSMUST00000020099.5
 Cdk1

cyclin-dependent kinase 1

chr17_+_56304313 10.665 ENSMUST00000113035.1
ENSMUST00000113039.2
ENSMUST00000142387.1
 Uhrf1


ubiquitin-like, containing PHD and RING finger domains, 1


chrX_-_51205773 10.333 ENSMUST00000114875.1
 Mbnl3
muscleblind-like 3 (Drosophila)
chr1_-_128359610 9.585 ENSMUST00000027601.4
 Mcm6
minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)
chr1_-_20820213 9.577 ENSMUST00000053266.9
 Mcm3
minichromosome maintenance deficient 3 (S. cerevisiae)
chr2_+_119112793 9.468 ENSMUST00000140939.1
ENSMUST00000028795.3
 Rad51

RAD51 homolog

chr10_-_60219260 8.528 ENSMUST00000135158.2
 Chst3
carbohydrate (chondroitin 6/keratan) sulfotransferase 3
chr12_-_69228167 8.379 ENSMUST00000021359.5
 Pole2
polymerase (DNA directed), epsilon 2 (p59 subunit)
chr15_-_9140374 8.169 ENSMUST00000096482.3
ENSMUST00000110585.2
 Skp2

S-phase kinase-associated protein 2 (p45)

chr13_-_55329723 8.016 ENSMUST00000021941.7
 Mxd3
Max dimerization protein 3
chr6_-_88898664 7.761 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr5_+_114130386 7.634 ENSMUST00000031587.6
 Ung
uracil DNA glycosylase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 43.8 GO:0006270 DNA replication initiation(GO:0006270)
3.8 38.1 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
4.0 31.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
3.7 25.8 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
0.4 24.5 GO:0008156 negative regulation of DNA replication(GO:0008156)
1.3 21.6 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
1.5 21.4 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.2 19.2 GO:0006342 chromatin silencing(GO:0006342)
0.5 15.7 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
1.3 15.1 GO:0000076 DNA replication checkpoint(GO:0000076)
4.1 12.3 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 11.4 GO:0006260 DNA replication(GO:0006260)
0.3 10.5 GO:0043550 regulation of lipid kinase activity(GO:0043550)
1.1 9.9 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
1.4 9.5 GO:1902969 mitotic DNA replication(GO:1902969)
1.0 9.1 GO:0090166 Golgi disassembly(GO:0090166)
1.5 8.7 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.7 8.2 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.3 7.8 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
2.5 7.6 GO:0006285 base-excision repair, AP site formation(GO:0006285)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 71.0 GO:0005634 nucleus(GO:0005634)
3.7 55.5 GO:0042555 MCM complex(GO:0042555)
0.6 33.4 GO:0005657 replication fork(GO:0005657)
0.2 27.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 24.1 GO:0005667 transcription factor complex(GO:0005667)
0.3 23.4 GO:0000786 nucleosome(GO:0000786)
4.3 21.6 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.9 13.1 GO:0031298 replication fork protection complex(GO:0031298)
2.3 11.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 10.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
2.0 9.9 GO:0035189 Rb-E2F complex(GO:0035189)
0.5 8.2 GO:0000800 lateral element(GO:0000800)
0.1 7.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 7.2 GO:0000790 nuclear chromatin(GO:0000790)
0.8 7.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 7.0 GO:0005871 kinesin complex(GO:0005871)
0.9 6.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.3 5.3 GO:1904115 axon cytoplasm(GO:1904115)
0.5 5.0 GO:0034709 methylosome(GO:0034709)
0.1 4.9 GO:0032993 protein-DNA complex(GO:0032993)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 141 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 37.0 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.2 36.5 GO:0001047 core promoter binding(GO:0001047)
1.8 25.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 22.4 GO:0070491 repressing transcription factor binding(GO:0070491)
4.3 21.6 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.5 20.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
4.7 18.7 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.1 17.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.7 16.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.5 16.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 16.3 GO:0004386 helicase activity(GO:0004386)
1.9 13.6 GO:0000150 recombinase activity(GO:0000150)
0.9 12.9 GO:0035173 histone kinase activity(GO:0035173)
0.0 10.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 9.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
2.1 8.5 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.1 8.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 8.3 GO:0042393 histone binding(GO:0042393)
1.4 8.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
1.9 7.6 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 63.4 PID_E2F_PATHWAY E2F transcription factor network
1.2 51.4 PID_ATR_PATHWAY ATR signaling pathway
2.2 30.5 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
2.4 21.8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.2 15.7 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 10.6 PID_PLK1_PATHWAY PLK1 signaling events
0.4 10.5 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.1 9.9 PID_CMYB_PATHWAY C-MYB transcription factor network
0.1 9.8 PID_BETA_CATENIN_NUC_PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.2 8.3 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.2 5.9 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.2 5.9 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.1 3.5 PID_TAP63_PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 3.5 PID_ATF2_PATHWAY ATF-2 transcription factor network
0.2 3.2 PID_IL5_PATHWAY IL5-mediated signaling events
0.1 3.1 PID_TOLL_ENDOGENOUS_PATHWAY Endogenous TLR signaling
0.1 2.9 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 2.8 PID_NOTCH_PATHWAY Notch signaling pathway
0.2 2.7 PID_BARD1_PATHWAY BARD1 signaling events
0.1 2.4 PID_RANBP2_PATHWAY Sumoylation by RanBP2 regulates transcriptional repression

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.7 67.2 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
4.0 63.3 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
3.7 40.3 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.4 23.7 REACTOME_MEIOTIC_RECOMBINATION Genes involved in Meiotic Recombination
1.6 22.3 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
1.1 13.0 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.7 12.1 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.1 11.1 REACTOME_SIGNALING_BY_RHO_GTPASES Genes involved in Signaling by Rho GTPases
0.5 9.9 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
1.0 8.8 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 8.8 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 8.2 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.3 8.1 REACTOME_G1_PHASE Genes involved in G1 Phase
0.2 7.8 REACTOME_MRNA_SPLICING_MINOR_PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.3 7.0 REACTOME_KINESINS Genes involved in Kinesins
0.1 6.6 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 6.0 REACTOME_RNA_POL_I_TRANSCRIPTION Genes involved in RNA Polymerase I Transcription
1.3 5.3 REACTOME_LAGGING_STRAND_SYNTHESIS Genes involved in Lagging Strand Synthesis
0.3 4.8 REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.2 3.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation