Motif ID: Sp1

Z-value: 2.224


Transcription factors associated with Sp1:

Gene SymbolEntrez IDGene Name
Sp1 ENSMUSG00000001280.6 Sp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp1mm10_v2_chr15_+_102406143_1024063800.371.3e-01Click!


Activity profile for motif Sp1.

activity profile for motif Sp1


Sorted Z-values histogram for motif Sp1

Sorted Z-values for motif Sp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56971762 9.711 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr5_+_134986191 7.842 ENSMUST00000094245.2
 Cldn3
claudin 3
chr2_+_172345565 7.477 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr1_-_56972437 7.051 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr12_-_100725028 6.514 ENSMUST00000043599.6
 Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr12_+_12262139 6.485 ENSMUST00000069066.6
ENSMUST00000069005.8
 Fam49a

family with sequence similarity 49, member A

chrX_-_160994665 6.305 ENSMUST00000087104.4
 Cdkl5
cyclin-dependent kinase-like 5
chr4_-_133498538 6.271 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr16_+_93711907 6.158 ENSMUST00000045004.9
 Dopey2
dopey family member 2
chr7_+_44310213 6.055 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr2_-_33130565 6.021 ENSMUST00000124000.1
 Garnl3
GTPase activating RANGAP domain-like 3
chr18_+_67933257 5.889 ENSMUST00000063775.3
 Ldlrad4
low density lipoprotein receptor class A domain containing 4
chr1_-_161034794 5.796 ENSMUST00000177003.1
ENSMUST00000162226.2
ENSMUST00000159250.2
 Zbtb37


zinc finger and BTB domain containing 37


chr10_-_127620960 5.793 ENSMUST00000121829.1
 Lrp1
low density lipoprotein receptor-related protein 1
chr8_-_29219338 5.737 ENSMUST00000168630.2
 Unc5d
unc-5 homolog D (C. elegans)
chr8_-_84800024 5.701 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr9_+_44043384 5.681 ENSMUST00000114840.1
 Thy1
thymus cell antigen 1, theta
chr7_-_79149042 5.656 ENSMUST00000032825.8
ENSMUST00000107409.3
 Mfge8

milk fat globule-EGF factor 8 protein

chr7_-_27396542 5.561 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr7_+_25268387 5.460 ENSMUST00000169392.1
 Cic
capicua homolog (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,040 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 29.8 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.4 24.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.4 15.6 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
1.0 15.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.9 15.5 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.9 15.5 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
1.7 15.2 GO:0032484 Ral protein signal transduction(GO:0032484)
0.4 14.7 GO:0032456 endocytic recycling(GO:0032456)
1.4 13.8 GO:0010459 negative regulation of heart rate(GO:0010459)
0.6 13.1 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
3.2 12.9 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
1.1 12.7 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
0.7 12.0 GO:0006895 Golgi to endosome transport(GO:0006895)
0.8 11.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
2.0 11.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.6 11.4 GO:0007252 I-kappaB phosphorylation(GO:0007252)
2.8 11.1 GO:0044268 multicellular organismal protein metabolic process(GO:0044268)
0.3 11.1 GO:0031338 regulation of vesicle fusion(GO:0031338)
1.1 10.8 GO:0046959 habituation(GO:0046959)
0.4 10.8 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 335 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 64.5 GO:0016021 integral component of membrane(GO:0016021)
0.2 50.0 GO:0099572 postsynaptic specialization(GO:0099572)
0.2 35.3 GO:0000139 Golgi membrane(GO:0000139)
0.9 34.8 GO:0048786 presynaptic active zone(GO:0048786)
0.5 33.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.8 29.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 25.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 24.9 GO:0055037 recycling endosome(GO:0055037)
0.1 22.9 GO:0005768 endosome(GO:0005768)
0.3 22.8 GO:0043198 dendritic shaft(GO:0043198)
0.2 20.2 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 19.2 GO:0005802 trans-Golgi network(GO:0005802)
0.5 17.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 16.1 GO:0016323 basolateral plasma membrane(GO:0016323)
0.4 15.7 GO:0034704 calcium channel complex(GO:0034704)
1.2 15.3 GO:0044327 dendritic spine head(GO:0044327)
0.8 14.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.5 14.2 GO:0043194 axon initial segment(GO:0043194)
0.5 13.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.2 13.4 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 566 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 64.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.4 61.6 GO:0017137 Rab GTPase binding(GO:0017137)
0.2 38.8 GO:0005096 GTPase activator activity(GO:0005096)
0.2 30.5 GO:0008017 microtubule binding(GO:0008017)
0.3 27.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.4 25.2 GO:0030507 spectrin binding(GO:0030507)
0.1 20.3 GO:0003779 actin binding(GO:0003779)
0.2 18.8 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.5 14.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.5 14.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 14.1 GO:0043274 phospholipase binding(GO:0043274)
0.3 13.9 GO:0005262 calcium channel activity(GO:0005262)
0.4 13.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 13.6 GO:0048365 Rac GTPase binding(GO:0048365)
0.6 13.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
4.4 13.2 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
1.3 12.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.4 12.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.3 12.2 GO:0015485 cholesterol binding(GO:0015485)
2.0 11.9 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 99 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 41.6 PID_REELIN_PATHWAY Reelin signaling pathway
0.5 26.6 PID_ERBB1_INTERNALIZATION_PATHWAY Internalization of ErbB1
0.7 20.9 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.5 19.4 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
1.1 18.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.2 16.5 PID_LKB1_PATHWAY LKB1 signaling events
0.7 16.2 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.5 15.4 PID_NFKAPPAB_CANONICAL_PATHWAY Canonical NF-kappaB pathway
0.3 14.6 PID_SHP2_PATHWAY SHP2 signaling
0.3 12.5 PID_RAC1_REG_PATHWAY Regulation of RAC1 activity
0.5 12.0 PID_UPA_UPAR_PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 11.1 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.2 10.8 PID_RHOA_PATHWAY RhoA signaling pathway
0.2 9.4 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.5 8.8 PID_SYNDECAN_3_PATHWAY Syndecan-3-mediated signaling events
0.4 8.5 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 8.4 PID_RHOA_REG_PATHWAY Regulation of RhoA activity
0.0 6.7 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.5 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 6.3 PID_IL12_STAT4_PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 160 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 30.3 REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5 22.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.3 21.8 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.4 21.6 REACTOME_NETRIN1_SIGNALING Genes involved in Netrin-1 signaling
0.6 21.5 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.5 19.2 REACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.6 16.4 REACTOME_UNBLOCKING_OF_NMDA_RECEPTOR_GLUTAMATE_BINDING_AND_ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.6 13.5 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.3 13.3 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.8 12.4 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.6 12.1 REACTOME_CRMPS_IN_SEMA3A_SIGNALING Genes involved in CRMPs in Sema3A signaling
0.4 11.5 REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.4 11.5 REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT Genes involved in ABC-family proteins mediated transport
0.6 11.0 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.8 9.6 REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY Genes involved in Adenylate cyclase activating pathway
0.3 9.6 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
0.7 9.4 REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 9.4 REACTOME_CIRCADIAN_CLOCK Genes involved in Circadian Clock
0.3 9.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_PLASMA_MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.2 8.9 REACTOME_POTASSIUM_CHANNELS Genes involved in Potassium Channels