Motif ID: Pou4f1_Pou6f1

Z-value: 0.993

Transcription factors associated with Pou4f1_Pou6f1:

Gene SymbolEntrez IDGene Name
Pou4f1 ENSMUSG00000048349.8 Pou4f1
Pou6f1 ENSMUSG00000009739.10 Pou6f1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pou6f1mm10_v2_chr15_-_100599983_1006000390.522.6e-02Click!
Pou4f1mm10_v2_chr14_-_104467984_104468041-0.243.5e-01Click!


Activity profile for motif Pou4f1_Pou6f1.

activity profile for motif Pou4f1_Pou6f1


Sorted Z-values histogram for motif Pou4f1_Pou6f1

Sorted Z-values for motif Pou4f1_Pou6f1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pou4f1_Pou6f1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_92161343 2.581 ENSMUST00000068378.5
 Cntn1
contactin 1
chr14_-_30353468 2.328 ENSMUST00000112249.1
 Cacna1d
calcium channel, voltage-dependent, L type, alpha 1D subunit
chr13_+_42681513 2.153 ENSMUST00000149235.1
 Phactr1
phosphatase and actin regulator 1
chr9_+_113812547 1.752 ENSMUST00000166734.2
ENSMUST00000111838.2
ENSMUST00000163895.2
 Clasp2


CLIP associating protein 2


chr11_+_98348404 1.637 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr15_-_100599864 1.449 ENSMUST00000177247.2
ENSMUST00000177505.2
 Pou6f1

POU domain, class 6, transcription factor 1

chr13_+_83504032 1.398 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr4_+_102254993 1.385 ENSMUST00000106908.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr1_-_56978534 1.343 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr16_+_91269759 1.321 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr4_+_152338619 1.317 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5

chr1_+_180101144 1.310 ENSMUST00000133890.1
 Cdc42bpa
CDC42 binding protein kinase alpha
chr2_-_177202829 1.299 ENSMUST00000133301.1
 Gm14410
predicted gene 14410
chr8_+_12984246 1.229 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
 Mcf2l


mcf.2 transforming sequence-like


chr2_+_176711933 1.221 ENSMUST00000108983.2
 Gm14305
predicted gene 14305
chr2_+_176802233 1.136 ENSMUST00000132883.1
 Gm14295
predicted gene 14295
chr2_+_82053222 1.124 ENSMUST00000047527.7
 Zfp804a
zinc finger protein 804A
chr15_-_100599983 1.122 ENSMUST00000073837.6
 Pou6f1
POU domain, class 6, transcription factor 1
chr2_+_177004553 1.100 ENSMUST00000126358.1
 Gm14419
predicted gene 14419
chr2_-_175203061 1.058 ENSMUST00000165892.1
 Gm14391
predicted gene 14391

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 4.3 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 3.0 GO:0007097 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023)
0.0 2.6 GO:0010765 positive regulation of sodium ion transport(GO:0010765)
0.6 2.3 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.3 2.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 1.9 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.3 1.8 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 1.8 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.1 1.8 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.1 1.7 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.5 1.6 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 1.5 GO:1902004 positive regulation of beta-amyloid formation(GO:1902004)
0.5 1.4 GO:0007521 muscle cell fate determination(GO:0007521) cellular response to parathyroid hormone stimulus(GO:0071374) positive regulation of macrophage apoptotic process(GO:2000111)
0.2 1.3 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 1.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0 1.2 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.2 1.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.2 1.0 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.1 1.0 GO:0016082 synaptic vesicle priming(GO:0016082)
0.0 1.0 GO:0086010 membrane depolarization during action potential(GO:0086010)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 4.0 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 3.0 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 2.2 GO:0042641 actomyosin(GO:0042641)
0.0 1.9 GO:0030017 sarcomere(GO:0030017)
0.4 1.8 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 1.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 1.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 1.0 GO:0033263 CORVET complex(GO:0033263)
0.1 1.0 GO:0048787 presynaptic active zone membrane(GO:0048787)
0.1 1.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 1.0 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.9 GO:0005814 centriole(GO:0005814)
0.2 0.8 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
0.1 0.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 0.7 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 4.7 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.3 2.3 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1 2.2 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 2.2 GO:0030246 carbohydrate binding(GO:0030246)
0.1 2.1 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 1.8 GO:0002162 dystroglycan binding(GO:0002162)
0.1 1.8 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.5 1.6 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.1 1.4 GO:0003680 AT DNA binding(GO:0003680)
0.3 1.3 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.1 1.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 1.0 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.1 1.0 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.1 1.0 GO:0031402 sodium ion binding(GO:0031402)
0.1 0.8 GO:1904315 GABA-gated chloride ion channel activity(GO:0022851) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 0.8 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1 0.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 0.7 GO:0016160 alpha-amylase activity(GO:0004556) amylase activity(GO:0016160)
0.2 0.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.7 GO:0097016 L27 domain binding(GO:0097016)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.8 PID_CDC42_PATHWAY CDC42 signaling events
0.0 2.1 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 1.4 PID_MAPK_TRK_PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 1.3 PID_NOTCH_PATHWAY Notch signaling pathway
0.0 1.2 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.1 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.0 0.8 PID_TNF_PATHWAY TNF receptor signaling pathway
0.0 0.5 PID_FOXO_PATHWAY FoxO family signaling
0.0 0.4 PID_TCR_CALCIUM_PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.3 PID_S1P_S1P4_PATHWAY S1P4 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 6.3 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.1 2.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 2.1 REACTOME_MYOGENESIS Genes involved in Myogenesis
0.0 1.3 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.0 REACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.9 REACTOME_ADHERENS_JUNCTIONS_INTERACTIONS Genes involved in Adherens junctions interactions
0.1 0.8 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.8 REACTOME_GABA_A_RECEPTOR_ACTIVATION Genes involved in GABA A receptor activation
0.0 0.7 REACTOME_METABOLISM_OF_PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME_PLC_BETA_MEDIATED_EVENTS Genes involved in PLC beta mediated events
0.0 0.6 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.5 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.1 0.4 REACTOME_EICOSANOID_LIGAND_BINDING_RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.0 0.4 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.4 REACTOME_PD1_SIGNALING Genes involved in PD-1 signaling
0.0 0.3 REACTOME_ENDOGENOUS_STEROLS Genes involved in Endogenous sterols
0.0 0.3 REACTOME_REGULATION_OF_INSULIN_LIKE_GROWTH_FACTOR_IGF_ACTIVITY_BY_INSULIN_LIKE_GROWTH_FACTOR_BINDING_PROTEINS_IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.2 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport