Motif ID: Relb

Z-value: 0.641


Transcription factors associated with Relb:

Gene SymbolEntrez IDGene Name
Relb ENSMUSG00000002983.10 Relb

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Relbmm10_v2_chr7_-_19629355_196294510.643.9e-03Click!


Activity profile for motif Relb.

activity profile for motif Relb


Sorted Z-values histogram for motif Relb

Sorted Z-values for motif Relb



Network of associatons between targets according to the STRING database.



First level regulatory network of Relb

PNG image of the network

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Top targets:


Showing 1 to 20 of 69 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_5714490 3.295 ENSMUST00000044009.7
Camk1d
calcium/calmodulin-dependent protein kinase ID
chr14_+_80000292 2.626 ENSMUST00000088735.3
Olfm4
olfactomedin 4
chr15_-_79164477 2.101 ENSMUST00000040019.4
Sox10
SRY-box containing gene 10
chr7_+_99535652 1.417 ENSMUST00000032995.8
ENSMUST00000162404.1
Arrb1

arrestin, beta 1

chr7_+_99535439 1.364 ENSMUST00000098266.2
ENSMUST00000179755.1
Arrb1

arrestin, beta 1

chr2_-_5063996 1.297 ENSMUST00000114996.1
Optn
optineurin
chr9_+_64385626 1.267 ENSMUST00000093829.2
ENSMUST00000118485.1
ENSMUST00000164113.1
Megf11


multiple EGF-like-domains 11


chr3_-_107760221 1.148 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
Csf1


colony stimulating factor 1 (macrophage)


chr2_-_5063932 1.122 ENSMUST00000027986.4
Optn
optineurin
chr3_-_9610074 1.015 ENSMUST00000041124.7
Zfp704
zinc finger protein 704
chr5_+_150259922 0.967 ENSMUST00000087204.5
Fry
furry homolog (Drosophila)
chrX_+_163909132 0.918 ENSMUST00000033734.7
ENSMUST00000112294.2
Ap1s2

adaptor-related protein complex 1, sigma 2 subunit

chr9_+_64385675 0.907 ENSMUST00000068967.4
Megf11
multiple EGF-like-domains 11
chr18_+_36559972 0.887 ENSMUST00000134146.1
Ankhd1
ankyrin repeat and KH domain containing 1
chr13_+_83732438 0.877 ENSMUST00000182701.1
C130071C03Rik
RIKEN cDNA C130071C03 gene
chr7_+_43463145 0.849 ENSMUST00000107977.1
Vsig10l
ZV-set and immunoglobulin domain containing 10 like
chr5_+_90759299 0.789 ENSMUST00000031318.4
Cxcl5
chemokine (C-X-C motif) ligand 5
chrX_+_163908982 0.784 ENSMUST00000069041.8
Ap1s2
adaptor-related protein complex 1, sigma 2 subunit
chr18_+_37484955 0.764 ENSMUST00000053856.4
Pcdhb17
protocadherin beta 17
chr3_+_7612702 0.732 ENSMUST00000181286.1
Gm16685
predicted gene, 16685

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 3.3 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.5 2.8 GO:0042699 follicle-stimulating hormone signaling pathway(GO:0042699)
0.1 2.6 GO:1900026 positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.6 2.4 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.1 2.2 GO:0010842 retina layer formation(GO:0010842)
0.4 2.1 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.0 1.7 GO:0060612 adipose tissue development(GO:0060612)
0.4 1.1 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1 1.0 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.3 0.8 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)
0.1 0.7 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.1 0.7 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.6 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.6 GO:0016322 neuron remodeling(GO:0016322)
0.2 0.5 GO:1900226 negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.1 0.5 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 0.4 GO:0036015 response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.1 0.4 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.4 GO:1900194 negative regulation of oocyte maturation(GO:1900194)

Gene overrepresentation in cellular_component category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.8 GO:0031143 pseudopodium(GO:0031143)
0.2 2.6 GO:0042581 specific granule(GO:0042581)
0.3 2.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0 1.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.4 1.1 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.5 GO:0033010 paranodal junction(GO:0033010)
0.0 0.5 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)

Gene overrepresentation in molecular_function category:

Showing 1 to 19 of 19 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.3 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.9 2.8 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.3 2.4 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 2.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.7 GO:0008565 protein transporter activity(GO:0008565)
0.0 1.1 GO:0005125 cytokine activity(GO:0005125)
0.2 0.6 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 0.6 GO:0035250 UDP-galactosyltransferase activity(GO:0035250)
0.1 0.5 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739) tubulin deacetylase activity(GO:0042903)
0.1 0.4 GO:0004103 choline kinase activity(GO:0004103)
0.1 0.4 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.4 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.4 GO:0005355 glucose transmembrane transporter activity(GO:0005355)
0.0 0.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0 0.3 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.0 0.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.1 1.1 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.7 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.
0.0 0.5 PID_HDAC_CLASSIII_PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.4 PID_TCR_RAS_PATHWAY Ras signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 12 of 12 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 REACTOME_LYSOSOME_VESICLE_BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 1.7 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.6 REACTOME_SEMA3A_PLEXIN_REPULSION_SIGNALING_BY_INHIBITING_INTEGRIN_ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME_FACILITATIVE_NA_INDEPENDENT_GLUCOSE_TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.4 REACTOME_SYNTHESIS_OF_PE Genes involved in Synthesis of PE
0.0 0.4 REACTOME_IL_6_SIGNALING Genes involved in Interleukin-6 signaling
0.0 0.4 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.3 REACTOME_NOD1_2_SIGNALING_PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.2 REACTOME_NFKB_IS_ACTIVATED_AND_SIGNALS_SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.1 REACTOME_TAK1_ACTIVATES_NFKB_BY_PHOSPHORYLATION_AND_ACTIVATION_OF_IKKS_COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex