Motif ID: Sox4

Z-value: 0.487


Transcription factors associated with Sox4:

Gene SymbolEntrez IDGene Name
Sox4 ENSMUSG00000076431.4 Sox4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox4mm10_v2_chr13_-_28953690_28953713-0.494.0e-02Click!


Activity profile for motif Sox4.

activity profile for motif Sox4


Sorted Z-values histogram for motif Sox4

Sorted Z-values for motif Sox4



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox4

PNG image of the network

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Top targets:


Showing 1 to 20 of 116 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103853199 3.084 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr17_-_70851189 1.346 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chrX_+_73639414 1.195 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr7_+_45216671 1.191 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr3_+_131110350 1.099 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr9_+_85842852 0.999 ENSMUST00000098500.3
 Tpbg
trophoblast glycoprotein
chr18_-_62756275 0.853 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr12_-_54986363 0.785 ENSMUST00000173433.1
ENSMUST00000173803.1
 Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr13_+_117220584 0.779 ENSMUST00000022242.7
 Emb
embigin
chr9_-_103480328 0.773 ENSMUST00000124310.2
 Bfsp2
beaded filament structural protein 2, phakinin
chr17_-_70853482 0.763 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr7_-_100514800 0.694 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr19_+_56874249 0.669 ENSMUST00000026068.7
 Vwa2
von Willebrand factor A domain containing 2
chr11_+_88068242 0.589 ENSMUST00000018521.4
 Vezf1
vascular endothelial zinc finger 1
chr1_+_153665274 0.583 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr5_+_115908644 0.576 ENSMUST00000141101.1
 Cit
citron
chr5_+_75075464 0.571 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr3_+_146500071 0.564 ENSMUST00000119130.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr7_+_100493795 0.545 ENSMUST00000129324.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr15_+_102296256 0.532 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 3.1 GO:0015671 oxygen transport(GO:0015671)
0.1 2.1 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 1.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 1.2 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.2 GO:0048368 lateral mesoderm development(GO:0048368)
0.4 1.1 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 0.9 GO:1990845 adaptive thermogenesis(GO:1990845)
0.1 0.8 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 0.8 GO:0070307 lens fiber cell development(GO:0070307)
0.2 0.7 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.1 0.7 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.7 GO:0035082 axoneme assembly(GO:0035082)
0.1 0.6 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.0 0.6 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.0 0.6 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.1 0.5 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.5 GO:0000212 meiotic spindle organization(GO:0000212)
0.0 0.5 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.0 0.5 GO:0043171 peptide catabolic process(GO:0043171)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 3.1 GO:0005833 hemoglobin complex(GO:0005833)
0.4 1.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.3 1.2 GO:0008623 CHRAC(GO:0008623)
0.1 1.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.7 GO:0005882 intermediate filament(GO:0005882)
0.2 0.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.5 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1 0.3 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.1 0.3 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.3 GO:0033193 Lsd1/2 complex(GO:0033193)
0.0 0.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:1990023 mitotic spindle midzone(GO:1990023)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 23 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.1 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 2.1 GO:0070410 co-SMAD binding(GO:0070410)
0.1 1.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 1.2 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.2 1.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.2 0.9 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 0.5 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.5 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 0.5 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.4 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.1 0.4 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.3 GO:0050436 microfibril binding(GO:0050436)
0.0 0.3 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0 0.3 GO:0046790 virion binding(GO:0046790)
0.0 0.3 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.2 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)

Gene overrepresentation in C2:CP category:

Showing 1 to 6 of 6 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 PID_AR_PATHWAY Coregulation of Androgen receptor activity
0.0 1.6 PID_CMYB_PATHWAY C-MYB transcription factor network
0.0 1.2 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.9 PID_HNF3B_PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID_RHOA_PATHWAY RhoA signaling pathway
0.0 0.4 PID_WNT_NONCANONICAL_PATHWAY Noncanonical Wnt signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 1.2 REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.9 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.6 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PLC_BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.5 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.4 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.3 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME_BILE_SALT_AND_ORGANIC_ANION_SLC_TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters