Motif ID: Maff

Z-value: 0.532


Transcription factors associated with Maff:

Gene SymbolEntrez IDGene Name
Maff ENSMUSG00000042622.7 Maff

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Maffmm10_v2_chr15_+_79347534_79347556-0.253.2e-01Click!


Activity profile for motif Maff.

activity profile for motif Maff


Sorted Z-values histogram for motif Maff

Sorted Z-values for motif Maff



Network of associatons between targets according to the STRING database.



First level regulatory network of Maff

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_75308373 1.220 ENSMUST00000085164.5
 Sv2b
synaptic vesicle glycoprotein 2 b
chr2_-_84886692 0.752 ENSMUST00000054514.5
ENSMUST00000151799.1
 Rtn4rl2

reticulon 4 receptor-like 2

chr10_+_26078255 0.646 ENSMUST00000041011.3
 Gm9767
predicted gene 9767
chr7_-_64925560 0.602 ENSMUST00000149851.1
 Fam189a1
family with sequence similarity 189, member A1
chr18_+_60963517 0.552 ENSMUST00000115295.2
ENSMUST00000039904.6
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr19_+_58728887 0.490 ENSMUST00000048644.5
 Pnliprp1
pancreatic lipase related protein 1
chr9_-_111690313 0.488 ENSMUST00000035083.7
 Stac
src homology three (SH3) and cysteine rich domain
chr19_+_56722372 0.484 ENSMUST00000038949.4
 Adrb1
adrenergic receptor, beta 1
chr15_-_25413752 0.444 ENSMUST00000058845.7
 Basp1
brain abundant, membrane attached signal protein 1
chr3_+_127791374 0.394 ENSMUST00000171621.1
 Tifa
TRAF-interacting protein with forkhead-associated domain
chr7_-_44997535 0.386 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr10_+_62920648 0.363 ENSMUST00000144459.1
 Slc25a16
solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
chr13_+_48261427 0.362 ENSMUST00000021810.1
 Id4
inhibitor of DNA binding 4
chr4_+_94556546 0.359 ENSMUST00000094969.1
 Gm10306
predicted gene 10306
chr5_+_7179299 0.343 ENSMUST00000179460.1
 Tubb4b-ps1
tubulin, beta 4B class IVB, pseudogene 1
chr11_-_119228461 0.341 ENSMUST00000036113.3
 Tbc1d16
TBC1 domain family, member 16
chr9_+_65460926 0.338 ENSMUST00000034955.6
 Spg21
spastic paraplegia 21 homolog (human)
chr4_-_143299498 0.306 ENSMUST00000030317.7
 Pdpn
podoplanin
chr2_-_69206133 0.299 ENSMUST00000112320.1
 Spc25
SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr7_+_84528964 0.287 ENSMUST00000180387.1
 Gm2115
predicted gene 2115
chr3_-_108044801 0.268 ENSMUST00000178808.1
ENSMUST00000106670.1
ENSMUST00000029489.8
 Gstm4


glutathione S-transferase, mu 4


chr13_+_66932802 0.254 ENSMUST00000021990.3
 Ptdss1
phosphatidylserine synthase 1
chr9_+_65214690 0.254 ENSMUST00000069000.7
 Parp16
poly (ADP-ribose) polymerase family, member 16
chr1_-_88205674 0.253 ENSMUST00000119972.2
 Dnajb3
DnaJ (Hsp40) homolog, subfamily B, member 3
chr10_-_121626316 0.242 ENSMUST00000039810.7
 Xpot
exportin, tRNA (nuclear export receptor for tRNAs)
chr11_+_76945719 0.238 ENSMUST00000125145.1
 Blmh
bleomycin hydrolase
chr17_+_21690766 0.238 ENSMUST00000097384.1
 Gm10509
predicted gene 10509
chr11_-_120630126 0.237 ENSMUST00000106180.1
 Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr4_-_143299463 0.231 ENSMUST00000119654.1
 Pdpn
podoplanin
chr4_+_141239499 0.218 ENSMUST00000141834.2
 Arhgef19
Rho guanine nucleotide exchange factor (GEF) 19
chr14_-_37135126 0.213 ENSMUST00000042564.9
 Ghitm
growth hormone inducible transmembrane protein
chr18_+_33464163 0.212 ENSMUST00000097634.3
 Gm10549
predicted gene 10549
chr2_-_69206146 0.209 ENSMUST00000127243.1
ENSMUST00000149643.1
ENSMUST00000167875.2
ENSMUST00000005365.8
 Spc25



SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)



chr1_+_72307413 0.208 ENSMUST00000027379.8
 Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
chr19_-_57197556 0.200 ENSMUST00000099294.2
 Ablim1
actin-binding LIM protein 1
chr10_+_62920630 0.195 ENSMUST00000044977.3
 Slc25a16
solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16
chr16_-_22439719 0.193 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr1_+_127306706 0.192 ENSMUST00000171405.1
 Mgat5
mannoside acetylglucosaminyltransferase 5
chr13_-_54749849 0.191 ENSMUST00000135343.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr7_-_13037627 0.183 ENSMUST00000125964.1
 Ube2m
ubiquitin-conjugating enzyme E2M
chr5_-_135251209 0.181 ENSMUST00000062572.2
 Fzd9
frizzled homolog 9 (Drosophila)
chr18_-_33463615 0.178 ENSMUST00000051087.8
 Nrep
neuronal regeneration related protein
chr7_-_110862944 0.172 ENSMUST00000033050.3
 Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
chr12_-_80436571 0.169 ENSMUST00000054145.6
 Dcaf5
DDB1 and CUL4 associated factor 5
chr18_-_33463747 0.167 ENSMUST00000171533.1
 Nrep
neuronal regeneration related protein
chr13_-_54749627 0.162 ENSMUST00000099506.1
 Gprin1
G protein-regulated inducer of neurite outgrowth 1
chrX_+_93675088 0.162 ENSMUST00000045898.3
 Pcyt1b
phosphate cytidylyltransferase 1, choline, beta isoform
chr5_+_140505550 0.150 ENSMUST00000043050.8
ENSMUST00000124142.1
 Chst12

carbohydrate sulfotransferase 12

chr13_-_23710714 0.148 ENSMUST00000091707.6
ENSMUST00000006787.7
ENSMUST00000091706.6
 Hfe


hemochromatosis


chr9_+_45838572 0.144 ENSMUST00000078111.4
ENSMUST00000034591.4
 Bace1

beta-site APP cleaving enzyme 1

chr1_-_120074023 0.144 ENSMUST00000056089.7
 Tmem37
transmembrane protein 37
chr5_-_35525691 0.142 ENSMUST00000038676.5
 Cpz
carboxypeptidase Z
chr10_-_88605017 0.138 ENSMUST00000119185.1
ENSMUST00000121629.1
 Mybpc1

myosin binding protein C, slow-type

chr15_+_3270767 0.126 ENSMUST00000082424.4
ENSMUST00000159158.1
ENSMUST00000159216.1
ENSMUST00000160311.1
 Sepp1



selenoprotein P, plasma, 1



chr7_-_100964371 0.125 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr3_+_28805436 0.123 ENSMUST00000043867.5
 Rpl22l1
ribosomal protein L22 like 1
chr6_+_30401866 0.122 ENSMUST00000068240.6
ENSMUST00000068259.6
 Klhdc10

kelch domain containing 10

chr4_-_136886187 0.121 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr15_+_41789495 0.119 ENSMUST00000090095.5
ENSMUST00000022918.7
 Oxr1

oxidation resistance 1

chr8_-_12672135 0.118 ENSMUST00000000776.8
 Tubgcp3
tubulin, gamma complex associated protein 3
chr11_+_82115180 0.115 ENSMUST00000009329.2
 Ccl8
chemokine (C-C motif) ligand 8
chr17_+_27839974 0.111 ENSMUST00000071006.7
 Snrpc
U1 small nuclear ribonucleoprotein C
chr2_-_127831817 0.105 ENSMUST00000028858.7
 Bub1
budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)
chr5_+_8056527 0.104 ENSMUST00000148633.1
 Sri
sorcin
chr1_-_136260873 0.104 ENSMUST00000086395.5
 Gpr25
G protein-coupled receptor 25
chr18_-_33464007 0.096 ENSMUST00000168890.1
 Nrep
neuronal regeneration related protein
chr7_+_16944645 0.095 ENSMUST00000094807.5
 Pnmal2
PNMA-like 2
chr5_+_103754560 0.094 ENSMUST00000153165.1
ENSMUST00000031256.5
 Aff1

AF4/FMR2 family, member 1

chr14_-_37135310 0.084 ENSMUST00000165649.2
 Ghitm
growth hormone inducible transmembrane protein
chr5_+_104435112 0.083 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr11_+_82101836 0.082 ENSMUST00000000194.3
 Ccl12
chemokine (C-C motif) ligand 12
chr7_+_139214661 0.079 ENSMUST00000135509.1
 Lrrc27
leucine rich repeat containing 27
chr11_+_4883186 0.078 ENSMUST00000139737.1
 Nipsnap1
4-nitrophenylphosphatase domain and non-neuronal SNAP25-like protein homolog 1 (C. elegans)
chr4_+_102421518 0.074 ENSMUST00000106904.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr18_+_65582390 0.070 ENSMUST00000169679.1
ENSMUST00000183326.1
 Zfp532

zinc finger protein 532

chr16_+_72663143 0.057 ENSMUST00000023600.7
 Robo1
roundabout homolog 1 (Drosophila)
chr3_+_96161981 0.057 ENSMUST00000054356.9
 Mtmr11
myotubularin related protein 11
chr15_-_33687840 0.053 ENSMUST00000042021.3
 Tspyl5
testis-specific protein, Y-encoded-like 5
chr7_-_4684963 0.046 ENSMUST00000079970.4
 Hspbp1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr11_+_74830920 0.040 ENSMUST00000000291.2
 Mnt
max binding protein
chr5_+_110839973 0.037 ENSMUST00000066160.1
 Chek2
checkpoint kinase 2
chr11_-_116086929 0.026 ENSMUST00000074628.6
ENSMUST00000106444.3
 Wbp2

WW domain binding protein 2

chr11_-_120630516 0.020 ENSMUST00000106181.1
 Mafg
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
chr8_+_25532125 0.013 ENSMUST00000167764.1
 Fgfr1
fibroblast growth factor receptor 1
chr4_+_139352587 0.010 ENSMUST00000147999.1
ENSMUST00000042096.7
ENSMUST00000179784.1
ENSMUST00000082262.7
 Ubr4
Emc1


ubiquitin protein ligase E3 component n-recognin 4
ER membrane protein complex subunit 1


chr9_-_57765845 0.010 ENSMUST00000065330.6
 Clk3
CDC-like kinase 3
chr1_+_75382114 0.009 ENSMUST00000113590.1
ENSMUST00000148515.1
 Speg

SPEG complex locus

chr4_-_94556737 0.006 ENSMUST00000030313.8
 Caap1
caspase activity and apoptosis inhibitor 1
chr3_-_59262825 0.004 ENSMUST00000050360.7
 P2ry12
purinergic receptor P2Y, G-protein coupled 12

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:1900133 renin secretion into blood stream(GO:0002001) regulation of renin secretion into blood stream(GO:1900133)
0.1 0.5 GO:1901731 positive regulation of platelet aggregation(GO:1901731)
0.1 0.4 GO:0060741 prostate gland stromal morphogenesis(GO:0060741)
0.1 0.3 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.1 0.3 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.1 0.2 GO:1990523 bone regeneration(GO:1990523)
0.1 0.2 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 0.2 GO:0071475 cellular hyperosmotic salinity response(GO:0071475) negative regulation of t-circle formation(GO:1904430)
0.1 0.2 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.1 GO:0002725 negative regulation of antigen processing and presentation(GO:0002578) negative regulation of T cell cytokine production(GO:0002725)
0.0 0.6 GO:0099628 receptor diffusion trapping(GO:0098953) postsynaptic neurotransmitter receptor diffusion trapping(GO:0098970) neurotransmitter receptor diffusion trapping(GO:0099628)
0.0 0.1 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.2 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.4 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.3 GO:0018916 nitrobenzene metabolic process(GO:0018916)
0.0 0.8 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.1 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:2000501 natural killer cell chemotaxis(GO:0035747) negative regulation of lymphocyte migration(GO:2000402) regulation of natural killer cell chemotaxis(GO:2000501)
0.0 0.4 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.1 GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0 0.1 GO:0035937 androgen catabolic process(GO:0006710) estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.0 0.2 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.0 0.1 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 0.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.6 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.0 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
0.0 0.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0099573 glutamatergic postsynaptic density(GO:0099573)
0.1 0.5 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.5 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 0.2 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.1 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.0 0.1 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.1 GO:1990357 terminal web(GO:1990357)
0.0 0.1 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0005827 equatorial microtubule organizing center(GO:0000923) polar microtubule(GO:0005827)
0.0 0.3 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.3 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.1 GO:0000243 commitment complex(GO:0000243)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0051379 epinephrine binding(GO:0051379)
0.0 0.5 GO:0015250 water channel activity(GO:0015250)
0.0 0.6 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.5 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0 0.2 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.3 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 0.1 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 0.2 GO:0070739 NEDD8 transferase activity(GO:0019788) protein-glutamic acid ligase activity(GO:0070739)
0.0 0.2 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.1 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.0 0.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0039706 co-receptor binding(GO:0039706)
0.0 0.1 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.1 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.3 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.5 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.2 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME_VITAMIN_B5_PANTOTHENATE_METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.5 REACTOME_AMINE_LIGAND_BINDING_RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.6 REACTOME_CREB_PHOSPHORYLATION_THROUGH_THE_ACTIVATION_OF_CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 0.1 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME_HYALURONAN_UPTAKE_AND_DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.1 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.0 0.2 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.1 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.3 REACTOME_GLUTATHIONE_CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME_N_GLYCAN_ANTENNAE_ELONGATION Genes involved in N-Glycan antennae elongation