Motif ID: Mecp2

Z-value: 2.793


Transcription factors associated with Mecp2:

Gene SymbolEntrez IDGene Name
Mecp2 ENSMUSG00000031393.10 Mecp2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Mecp2mm10_v2_chrX_-_74085586_74085652-0.107.0e-01Click!


Activity profile for motif Mecp2.

activity profile for motif Mecp2


Sorted Z-values histogram for motif Mecp2

Sorted Z-values for motif Mecp2



Network of associatons between targets according to the STRING database.



First level regulatory network of Mecp2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_127241807 10.361 ENSMUST00000119026.1
 Tmem132c
transmembrane protein 132C
chr6_-_72788952 9.638 ENSMUST00000114053.2
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr8_-_87959560 9.238 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr13_-_56252163 7.550 ENSMUST00000058475.4
 Neurog1
neurogenin 1
chr6_-_72789240 7.285 ENSMUST00000069536.5
 Tcf7l1
transcription factor 7 like 1 (T cell specific, HMG box)
chr7_-_25250720 7.082 ENSMUST00000116343.2
ENSMUST00000045847.8
 Erf

Ets2 repressor factor

chr2_+_27886416 6.933 ENSMUST00000028280.7
 Col5a1
collagen, type V, alpha 1
chr11_-_89302545 6.661 ENSMUST00000061728.3
 Nog
noggin
chr11_-_68386821 6.388 ENSMUST00000021284.3
 Ntn1
netrin 1
chr9_-_119578981 6.253 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr11_+_98412461 5.507 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr7_+_65862029 5.385 ENSMUST00000055576.5
ENSMUST00000098391.4
 Pcsk6

proprotein convertase subtilisin/kexin type 6

chr11_-_68386974 4.906 ENSMUST00000135141.1
 Ntn1
netrin 1
chr10_-_77113676 4.710 ENSMUST00000072755.4
ENSMUST00000105409.1
 Col18a1

collagen, type XVIII, alpha 1

chr14_-_98169542 4.622 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr8_+_54077532 4.609 ENSMUST00000033919.4
 Vegfc
vascular endothelial growth factor C
chr16_-_22161450 4.532 ENSMUST00000115379.1
 Igf2bp2
insulin-like growth factor 2 mRNA binding protein 2
chr10_-_42583628 4.441 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr17_-_56757516 4.403 ENSMUST00000044752.5
 Nrtn
neurturin
chr11_-_12037391 4.348 ENSMUST00000093321.5
 Grb10
growth factor receptor bound protein 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 1,188 entries
Log-likelihood per target Total log-likelihoodTermDescription
5.7 17.0 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
1.1 13.6 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
3.3 13.0 GO:0007354 zygotic determination of anterior/posterior axis, embryo(GO:0007354)
1.9 13.0 GO:0061312 BMP signaling pathway involved in heart development(GO:0061312)
1.4 10.8 GO:0044027 hypermethylation of CpG island(GO:0044027)
3.5 10.6 GO:1904274 tricellular tight junction assembly(GO:1904274)
1.6 9.9 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.4 8.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.3 8.2 GO:0007520 myoblast fusion(GO:0007520)
1.2 7.3 GO:0003383 apical constriction(GO:0003383)
1.4 7.2 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.8 7.2 GO:0001842 neural fold formation(GO:0001842)
0.2 7.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 7.0 GO:0051028 mRNA transport(GO:0051028)
2.3 6.9 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
0.3 6.9 GO:0021978 telencephalon regionalization(GO:0021978)
2.3 6.8 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
1.0 6.8 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838)
0.2 6.8 GO:0006270 DNA replication initiation(GO:0006270)
1.3 6.7 GO:0006564 L-serine biosynthetic process(GO:0006564)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 402 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 45.1 GO:0070062 extracellular exosome(GO:0070062)
0.2 30.0 GO:0044798 nuclear transcription factor complex(GO:0044798)
0.1 27.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 22.8 GO:0005667 transcription factor complex(GO:0005667)
0.2 22.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.6 14.8 GO:0001741 XY body(GO:0001741)
0.2 14.0 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
1.9 11.4 GO:0061689 tricellular tight junction(GO:0061689)
0.0 10.0 GO:0005925 focal adhesion(GO:0005925)
0.2 9.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
3.2 9.6 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
1.2 9.6 GO:0033269 internode region of axon(GO:0033269)
0.7 8.6 GO:0016600 flotillin complex(GO:0016600)
0.1 7.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 7.4 GO:0005844 polysome(GO:0005844)
0.8 7.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
2.3 6.9 GO:0005588 collagen type V trimer(GO:0005588)
0.1 6.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 6.7 GO:0016607 nuclear speck(GO:0016607)
1.6 6.5 GO:0060187 cell pole(GO:0060187)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 647 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.4 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.7 17.1 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.3 15.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
1.7 13.4 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.7 11.5 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 11.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.6 10.8 GO:0017166 vinculin binding(GO:0017166)
0.2 10.8 GO:0002039 p53 binding(GO:0002039)
0.8 10.1 GO:0001972 retinoic acid binding(GO:0001972)
0.3 9.8 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 9.5 GO:0042393 histone binding(GO:0042393)
0.0 9.0 GO:0045296 cadherin binding(GO:0045296)
0.1 8.6 GO:0008013 beta-catenin binding(GO:0008013)
0.4 8.4 GO:0070410 co-SMAD binding(GO:0070410)
0.5 8.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.3 8.2 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 7.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 7.7 GO:0005080 protein kinase C binding(GO:0005080)
0.8 7.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.2 7.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 24.3 PID_DELTA_NP63_PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 23.4 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.7 21.6 PID_WNT_SIGNALING_PATHWAY Wnt signaling network
0.3 18.7 PID_E2F_PATHWAY E2F transcription factor network
0.3 17.8 PID_BMP_PATHWAY BMP receptor signaling
0.3 16.3 PID_PLK1_PATHWAY PLK1 signaling events
0.3 13.5 PID_ILK_PATHWAY Integrin-linked kinase signaling
0.4 13.4 PID_FOXM1_PATHWAY FOXM1 transcription factor network
0.3 11.6 NABA_BASEMENT_MEMBRANES Genes encoding structural components of basement membranes
0.1 11.5 PID_MYC_ACTIV_PATHWAY Validated targets of C-MYC transcriptional activation
0.2 11.3 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.2 11.2 PID_CMYB_PATHWAY C-MYB transcription factor network
0.2 8.9 PID_HES_HEY_PATHWAY Notch-mediated HES/HEY network
0.1 8.4 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 8.2 PID_NECTIN_PATHWAY Nectin adhesion pathway
0.3 8.1 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.5 7.7 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 7.5 PID_CERAMIDE_PATHWAY Ceramide signaling pathway
0.2 6.6 ST_P38_MAPK_PATHWAY p38 MAPK Pathway
0.3 6.5 PID_LYMPH_ANGIOGENESIS_PATHWAY VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 196 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 19.1 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP
0.1 18.8 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.6 18.0 REACTOME_TIGHT_JUNCTION_INTERACTIONS Genes involved in Tight junction interactions
0.6 13.0 REACTOME_G0_AND_EARLY_G1 Genes involved in G0 and Early G1
0.2 11.5 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 10.5 REACTOME_NCAM1_INTERACTIONS Genes involved in NCAM1 interactions
0.2 10.4 REACTOME_METABOLISM_OF_NON_CODING_RNA Genes involved in Metabolism of non-coding RNA
0.9 10.1 REACTOME_ROLE_OF_SECOND_MESSENGERS_IN_NETRIN1_SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.3 10.0 REACTOME_G_BETA_GAMMA_SIGNALLING_THROUGH_PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 9.9 REACTOME_TRANSLATION Genes involved in Translation
0.6 9.6 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.6 9.3 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.3 9.3 REACTOME_G1_PHASE Genes involved in G1 Phase
0.1 9.1 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 8.8 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.3 8.7 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 8.0 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.3 7.7 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.3 7.6 REACTOME_SIGNALING_BY_HIPPO Genes involved in Signaling by Hippo
0.1 7.5 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere