Motif ID: Spic

Z-value: 0.690


Transcription factors associated with Spic:

Gene SymbolEntrez IDGene Name
Spic ENSMUSG00000004359.10 Spic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_886830250.155.6e-01Click!


Activity profile for motif Spic.

activity profile for motif Spic


Sorted Z-values histogram for motif Spic

Sorted Z-values for motif Spic



Network of associatons between targets according to the STRING database.



First level regulatory network of Spic

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_126695942 0.933 ENSMUST00000106369.1
 Bola2
bolA-like 2 (E. coli)
chr5_+_44966583 0.909 ENSMUST00000079389.5
 4930431F12Rik
RIKEN cDNA 4930431F12 gene
chr7_+_28833975 0.891 ENSMUST00000066723.8
 Lgals4
lectin, galactose binding, soluble 4
chr17_-_25785533 0.890 ENSMUST00000140738.1
ENSMUST00000145053.1
ENSMUST00000138759.1
ENSMUST00000133071.1
ENSMUST00000077938.3
 Haghl




hydroxyacylglutathione hydrolase-like




chr4_-_118489755 0.819 ENSMUST00000184261.1
 Tie1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr17_-_25785324 0.806 ENSMUST00000150324.1
 Haghl
hydroxyacylglutathione hydrolase-like
chr12_-_4592927 0.742 ENSMUST00000170816.1
 Gm3625
predicted gene 3625
chr3_+_7612702 0.712 ENSMUST00000181286.1
 Gm16685
predicted gene, 16685
chr13_-_8038106 0.703 ENSMUST00000165220.2
 Gm9742
predicted gene 9742
chr10_+_112172540 0.687 ENSMUST00000132994.1
 Caps2
calcyphosphine 2
chr7_+_126695355 0.678 ENSMUST00000130498.1
 Bola2
bolA-like 2 (E. coli)
chrX_+_107255878 0.641 ENSMUST00000101294.2
ENSMUST00000118820.1
ENSMUST00000120971.1
 Gpr174


G protein-coupled receptor 174


chr11_-_77078404 0.637 ENSMUST00000102494.1
 Ccdc55
coiled-coil domain containing 55
chr10_+_58255465 0.622 ENSMUST00000057659.7
ENSMUST00000162041.1
ENSMUST00000162860.1
 Gcc2


GRIP and coiled-coil domain containing 2


chr16_+_77846693 0.614 ENSMUST00000169531.1
 Gm17333
predicted gene, 17333
chr11_-_102469839 0.610 ENSMUST00000103086.3
 Itga2b
integrin alpha 2b
chr11_-_11627824 0.605 ENSMUST00000081896.4
 4930512M02Rik
RIKEN cDNA 4930512M02 gene
chr8_-_70897407 0.588 ENSMUST00000054220.8
 Rpl18a
ribosomal protein L18A
chr11_-_106715251 0.576 ENSMUST00000080853.4
ENSMUST00000183610.1
ENSMUST00000103069.3
ENSMUST00000106796.2
 Pecam1



platelet/endothelial cell adhesion molecule 1



chr1_+_150393250 0.572 ENSMUST00000119161.2
 Tpr
translocated promoter region

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 110 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.7 GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.2 1.6 GO:0071569 protein ufmylation(GO:0071569)
0.4 1.1 GO:0032240 mRNA export from nucleus in response to heat stress(GO:0031990) negative regulation of nucleobase-containing compound transport(GO:0032240) negative regulation of RNA export from nucleus(GO:0046832)
0.1 0.8 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 0.7 GO:0060785 regulation of apoptosis involved in tissue homeostasis(GO:0060785)
0.1 0.7 GO:2000157 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
0.0 0.7 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.7 GO:0007035 vacuolar acidification(GO:0007035)
0.1 0.6 GO:0050904 diapedesis(GO:0050904)
0.1 0.6 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.1 0.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 0.6 GO:0051103 DNA ligation involved in DNA repair(GO:0051103)
0.0 0.6 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.6 GO:0000731 DNA synthesis involved in DNA repair(GO:0000731)
0.0 0.6 GO:0045026 plasma membrane fusion(GO:0045026)
0.0 0.6 GO:0070527 platelet aggregation(GO:0070527)
0.2 0.5 GO:0070476 rRNA (guanine-N7)-methylation(GO:0070476)
0.1 0.5 GO:0002309 T cell proliferation involved in immune response(GO:0002309)
0.1 0.5 GO:0035617 stress granule disassembly(GO:0035617) plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.5 GO:0048268 clathrin coat assembly(GO:0048268)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 1.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.9 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 0.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.8 GO:1990393 3M complex(GO:1990393)
0.1 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.2 0.7 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.1 0.7 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 0.7 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 0.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.6 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.6 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.1 0.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 0.5 GO:0035061 interchromatin granule(GO:0035061)
0.2 0.5 GO:0099631 postsynaptic endocytic zone cytoplasmic component(GO:0099631)
0.1 0.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.5 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.5 GO:0035253 ciliary rootlet(GO:0035253)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.2 1.7 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0 1.2 GO:0070840 dynein complex binding(GO:0070840)
0.1 1.0 GO:0031386 protein tag(GO:0031386)
0.1 1.0 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.8 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.0 0.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.2 0.7 GO:0072541 peroxynitrite reductase activity(GO:0072541)
0.2 0.7 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.1 0.7 GO:0016936 galactoside binding(GO:0016936)
0.1 0.7 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 0.7 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 0.7 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.1 0.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.6 GO:0070051 fibrinogen binding(GO:0070051)
0.1 0.6 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0 0.6 GO:0045125 bioactive lipid receptor activity(GO:0045125)

Gene overrepresentation in C2:CP category:

Showing 1 to 10 of 10 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.1 PID_DNA_PK_PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 1.1 PID_HDAC_CLASSII_PATHWAY Signaling events mediated by HDAC Class II
0.0 1.0 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.8 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.6 PID_CASPASE_PATHWAY Caspase cascade in apoptosis
0.0 0.5 PID_NCADHERIN_PATHWAY N-cadherin signaling events
0.0 0.4 PID_ERB_GENOMIC_PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.4 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 0.2 PID_TCR_JNK_PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.2 PID_LPA4_PATHWAY LPA4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.9 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.5 REACTOME_PEPTIDE_CHAIN_ELONGATION Genes involved in Peptide chain elongation
0.0 1.3 REACTOME_LATENT_INFECTION_OF_HOMO_SAPIENS_WITH_MYCOBACTERIUM_TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.0 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.1 0.7 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.7 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.0 0.6 REACTOME_P130CAS_LINKAGE_TO_MAPK_SIGNALING_FOR_INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.6 REACTOME_INTEGRATION_OF_PROVIRUS Genes involved in Integration of provirus
0.0 0.5 REACTOME_PECAM1_INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.5 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.5 REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.5 REACTOME_GAP_JUNCTION_DEGRADATION Genes involved in Gap junction degradation
0.0 0.5 REACTOME_INWARDLY_RECTIFYING_K_CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 0.4 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_GLUCAGON_LIKE_PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0 0.4 REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS Genes involved in Activation of BH3-only proteins
0.1 0.3 REACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.3 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.3 REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.3 REACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME_BRANCHED_CHAIN_AMINO_ACID_CATABOLISM Genes involved in Branched-chain amino acid catabolism