Motif ID: Ep300

Z-value: 0.603


Transcription factors associated with Ep300:

Gene SymbolEntrez IDGene Name
Ep300 ENSMUSG00000055024.6 Ep300

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Ep300mm10_v2_chr15_+_81586206_815862500.194.5e-01Click!


Activity profile for motif Ep300.

activity profile for motif Ep300


Sorted Z-values histogram for motif Ep300

Sorted Z-values for motif Ep300



Network of associatons between targets according to the STRING database.



First level regulatory network of Ep300

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_96522342 1.257 ENSMUST00000129737.1
 Tenm4
teneurin transmembrane protein 4
chr6_+_99692679 0.931 ENSMUST00000101122.1
 Gpr27
G protein-coupled receptor 27
chr19_+_23758819 0.796 ENSMUST00000025830.7
 Apba1
amyloid beta (A4) precursor protein binding, family A, member 1
chr2_+_163602331 0.787 ENSMUST00000152135.1
 Ttpal
tocopherol (alpha) transfer protein-like
chr11_+_97415527 0.771 ENSMUST00000121799.1
 Arhgap23
Rho GTPase activating protein 23
chr11_+_98348404 0.767 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr9_-_29411736 0.657 ENSMUST00000115236.1
 Ntm
neurotrimin
chr4_+_125490688 0.610 ENSMUST00000030676.7
 Grik3
glutamate receptor, ionotropic, kainate 3
chr8_-_84800344 0.608 ENSMUST00000099070.3
 Nfix
nuclear factor I/X
chr11_-_116307168 0.591 ENSMUST00000124281.1
 Exoc7
exocyst complex component 7
chr19_-_7105729 0.560 ENSMUST00000113383.2
 Flrt1
fibronectin leucine rich transmembrane protein 1
chr2_+_163602294 0.559 ENSMUST00000171696.1
ENSMUST00000109408.3
 Ttpal

tocopherol (alpha) transfer protein-like

chr4_+_103313806 0.534 ENSMUST00000035780.3
 Oma1
OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
chr13_-_29984219 0.517 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr7_+_127876796 0.515 ENSMUST00000131000.1
 Zfp646
zinc finger protein 646
chr12_+_86241848 0.486 ENSMUST00000071106.4
 Gpatch2l
G patch domain containing 2 like
chr8_+_112570043 0.472 ENSMUST00000034225.6
ENSMUST00000118171.1
 Cntnap4

contactin associated protein-like 4

chr2_+_91650116 0.469 ENSMUST00000111331.2
 Arhgap1
Rho GTPase activating protein 1
chr1_-_21961581 0.430 ENSMUST00000029667.6
ENSMUST00000173058.1
ENSMUST00000173404.1
 Kcnq5


potassium voltage-gated channel, subfamily Q, member 5


chr8_-_85840877 0.430 ENSMUST00000034140.7
 Itfg1
integrin alpha FG-GAP repeat containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 58 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.3 GO:0032289 central nervous system myelin formation(GO:0032289) cardiac cell fate specification(GO:0060912)
0.1 1.3 GO:0035635 entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.3 0.9 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.2 0.9 GO:0098706 ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0 0.9 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.3 0.8 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 0.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.1 0.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 0.6 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.6 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 0.5 GO:0070829 heterochromatin maintenance(GO:0070829)
0.1 0.5 GO:0010637 diet induced thermogenesis(GO:0002024) negative regulation of mitochondrial fusion(GO:0010637)
0.1 0.5 GO:1904217 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0 0.5 GO:2000821 regulation of grooming behavior(GO:2000821)
0.1 0.4 GO:0015803 branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820)
0.0 0.4 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0 0.4 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.1 0.3 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.1 0.3 GO:0021506 anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0032584 growth cone membrane(GO:0032584)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.9 GO:0097443 sorting endosome(GO:0097443)
0.0 0.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 0.7 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 0.5 GO:1990130 Iml1 complex(GO:1990130)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.5 GO:0097440 apical dendrite(GO:0097440)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.4 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.3 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.3 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 0.2 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.0 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 0.9 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.3 0.8 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 0.6 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.0 0.6 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.2 0.5 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.4 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.4 GO:0033883 pyridoxal phosphatase activity(GO:0033883)
0.0 0.4 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 0.3 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1 0.3 GO:0008061 chitin binding(GO:0008061)
0.0 0.3 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.3 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.3 GO:0050897 cobalt ion binding(GO:0050897)

Gene overrepresentation in C2:CP category:

Showing 1 to 9 of 9 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.3 PID_ARF6_TRAFFICKING_PATHWAY Arf6 trafficking events
0.0 0.9 PID_IL8_CXCR1_PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.6 PID_ATM_PATHWAY ATM pathway
0.0 0.4 PID_IL3_PATHWAY IL3-mediated signaling events
0.0 0.3 ST_INTERFERON_GAMMA_PATHWAY Interferon gamma pathway.
0.0 0.3 PID_CIRCADIAN_PATHWAY Circadian rhythm pathway
0.0 0.3 PID_S1P_S1P3_PATHWAY S1P3 pathway
0.0 0.1 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 16 of 16 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 REACTOME_INHIBITION_OF_VOLTAGE_GATED_CA2_CHANNELS_VIA_GBETA_GAMMA_SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.1 REACTOME_DARPP_32_EVENTS Genes involved in DARPP-32 events
0.0 0.8 REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.7 REACTOME_ZINC_TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.5 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.4 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.4 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.4 REACTOME_BASIGIN_INTERACTIONS Genes involved in Basigin interactions
0.0 0.2 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.2 REACTOME_PURINE_SALVAGE Genes involved in Purine salvage
0.0 0.2 REACTOME_PURINE_RIBONUCLEOSIDE_MONOPHOSPHATE_BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.2 REACTOME_MITOCHONDRIAL_TRNA_AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 0.2 REACTOME_SYNTHESIS_OF_SUBSTRATES_IN_N_GLYCAN_BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.1 REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0 0.1 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY Genes involved in Regulation of the Fanconi anemia pathway