Motif ID: Gsc2_Dmbx1

Z-value: 0.501

Transcription factors associated with Gsc2_Dmbx1:

Gene SymbolEntrez IDGene Name
Dmbx1 ENSMUSG00000028707.9 Dmbx1
Gsc2 ENSMUSG00000022738.6 Gsc2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Dmbx1mm10_v2_chr4_-_115939923_1159399280.174.9e-01Click!


Activity profile for motif Gsc2_Dmbx1.

activity profile for motif Gsc2_Dmbx1


Sorted Z-values histogram for motif Gsc2_Dmbx1

Sorted Z-values for motif Gsc2_Dmbx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Gsc2_Dmbx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 91 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_137766474 2.110 ENSMUST00000139951.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr14_-_118052235 1.525 ENSMUST00000022725.2
 Dct
dopachrome tautomerase
chr2_+_164562579 1.343 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr17_+_35861318 1.296 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr17_+_35861343 1.013 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr11_-_68973840 0.999 ENSMUST00000038644.4
 Rangrf
RAN guanine nucleotide release factor
chrM_+_8600 0.977 ENSMUST00000082409.1
 mt-Co3
mitochondrially encoded cytochrome c oxidase III
chr4_-_141053660 0.974 ENSMUST00000040222.7
 Crocc
ciliary rootlet coiled-coil, rootletin
chr7_-_133015248 0.908 ENSMUST00000169570.1
 Ctbp2
C-terminal binding protein 2
chr5_+_77265454 0.865 ENSMUST00000080359.5
 Rest
RE1-silencing transcription factor
chr13_-_116309639 0.791 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr9_+_50617516 0.780 ENSMUST00000141366.1
 Pih1d2
PIH1 domain containing 2
chr11_+_113659283 0.722 ENSMUST00000137878.1
 Cog1
component of oligomeric golgi complex 1
chr4_+_154960915 0.649 ENSMUST00000049621.6
 Hes5
hairy and enhancer of split 5 (Drosophila)
chr17_-_58991343 0.627 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr7_-_15879844 0.615 ENSMUST00000172758.1
ENSMUST00000044434.6
 Crx

cone-rod homeobox containing gene

chr13_-_23562369 0.605 ENSMUST00000105107.1
 Hist1h3e
histone cluster 1, H3e
chr1_+_12692430 0.571 ENSMUST00000180062.1
ENSMUST00000177608.1
 Sulf1

sulfatase 1

chr11_-_52282564 0.548 ENSMUST00000086844.3
 Tcf7
transcription factor 7, T cell specific
chr7_-_105752193 0.523 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.1 GO:0046677 response to antibiotic(GO:0046677)
0.3 1.5 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 1.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 1.3 GO:0032053 ciliary basal body organization(GO:0032053)
0.2 1.0 GO:0086028 bundle of His cell to Purkinje myocyte signaling(GO:0086028) bundle of His cell action potential(GO:0086043)
0.0 1.0 GO:0009060 aerobic respiration(GO:0009060)
0.2 0.9 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.1 0.9 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.3 0.8 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.0 0.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 0.6 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
0.1 0.6 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.0 0.6 GO:0018345 protein palmitoylation(GO:0018345)
0.2 0.5 GO:0048687 positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691)
0.1 0.5 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 0.5 GO:0002681 somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0 0.5 GO:0043171 peptide catabolic process(GO:0043171)
0.1 0.4 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 0.4 GO:0030576 Cajal body organization(GO:0030576)
0.0 0.4 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)

Gene overrepresentation in cellular_component category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0005652 nuclear lamina(GO:0005652)
0.1 2.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 1.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.5 GO:0000788 nuclear nucleosome(GO:0000788)
0.1 1.3 GO:0035253 ciliary rootlet(GO:0035253)
0.0 1.0 GO:0014704 intercalated disc(GO:0014704)
0.0 0.9 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.9 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.7 GO:0017119 Golgi transport complex(GO:0017119)
0.2 0.5 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 0.5 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.3 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0005921 gap junction(GO:0005921)
0.0 0.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 1.5 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 1.3 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0 1.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 1.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 0.9 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 0.9 GO:0015271 outward rectifier potassium channel activity(GO:0015271)
0.0 0.8 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 0.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.6 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.5 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.1 0.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.1 0.5 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
0.0 0.5 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.4 GO:0070140 isopeptidase activity(GO:0070122) ubiquitin-like protein-specific isopeptidase activity(GO:0070138) SUMO-specific isopeptidase activity(GO:0070140)
0.1 0.4 GO:1990932 5.8S rRNA binding(GO:1990932)
0.1 0.4 GO:0031432 titin binding(GO:0031432)

Gene overrepresentation in C2:CP category:

Showing 1 to 4 of 4 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.4 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.8 PID_ARF6_PATHWAY Arf6 signaling events
0.0 0.6 PID_CONE_PATHWAY Visual signal transduction: Cones
0.0 0.1 PID_RHODOPSIN_PATHWAY Visual signal transduction: Rods

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 7 of 7 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 REACTOME_RNA_POL_I_PROMOTER_OPENING Genes involved in RNA Polymerase I Promoter Opening
0.1 1.1 REACTOME_INCRETIN_SYNTHESIS_SECRETION_AND_INACTIVATION Genes involved in Incretin Synthesis, Secretion, and Inactivation
0.0 1.0 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.5 REACTOME_PEROXISOMAL_LIPID_METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME_PASSIVE_TRANSPORT_BY_AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.1 REACTOME_ORGANIC_CATION_ANION_ZWITTERION_TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.1 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway