Motif ID: Tbx21

Z-value: 1.138


Transcription factors associated with Tbx21:

Gene SymbolEntrez IDGene Name
Tbx21 ENSMUSG00000001444.2 Tbx21



Activity profile for motif Tbx21.

activity profile for motif Tbx21


Sorted Z-values histogram for motif Tbx21

Sorted Z-values for motif Tbx21



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx21

PNG image of the network

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Top targets:


Showing 1 to 20 of 134 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56969864 5.052 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr1_-_56969827 4.414 ENSMUST00000176759.1
 Satb2
special AT-rich sequence binding protein 2
chr9_-_112185726 4.094 ENSMUST00000160240.1
ENSMUST00000162065.1
 Arpp21

cyclic AMP-regulated phosphoprotein, 21

chr6_-_101377897 3.179 ENSMUST00000075994.6
 Pdzrn3
PDZ domain containing RING finger 3
chr9_-_112185939 2.987 ENSMUST00000070218.5
 Arpp21
cyclic AMP-regulated phosphoprotein, 21
chr18_+_67088287 2.858 ENSMUST00000025402.7
 Gnal
guanine nucleotide binding protein, alpha stimulating, olfactory type
chr7_+_45785331 2.625 ENSMUST00000120005.1
ENSMUST00000123585.1
 Lmtk3

lemur tyrosine kinase 3

chr2_-_66440753 2.318 ENSMUST00000112371.2
ENSMUST00000138910.1
 Scn1a

sodium channel, voltage-gated, type I, alpha

chr19_+_44989073 1.867 ENSMUST00000026225.8
 Sema4g
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chr5_-_138619653 1.847 ENSMUST00000129832.1
 Zfp68
zinc finger protein 68
chrX_+_170009659 1.827 ENSMUST00000179760.1
 Gm21887
predicted gene, 21887
chr3_-_127499095 1.823 ENSMUST00000182594.1
 Ank2
ankyrin 2, brain
chr18_+_37020097 1.811 ENSMUST00000047614.1
 Pcdha2
protocadherin alpha 2
chr1_+_34801704 1.727 ENSMUST00000047664.9
 Arhgef4
Rho guanine nucleotide exchange factor (GEF) 4
chr11_+_103171081 1.662 ENSMUST00000042286.5
 Fmnl1
formin-like 1
chr9_-_86546795 1.655 ENSMUST00000167814.1
 Gm17530
predicted gene, 17530
chr5_-_138619751 1.441 ENSMUST00000085852.4
ENSMUST00000110905.2
 Zfp68

zinc finger protein 68

chr8_+_12984246 1.427 ENSMUST00000110873.3
ENSMUST00000173006.1
ENSMUST00000145067.1
 Mcf2l


mcf.2 transforming sequence-like


chr10_-_13868779 1.395 ENSMUST00000105534.3
 Aig1
androgen-induced 1
chr10_-_13868932 1.327 ENSMUST00000019942.5
ENSMUST00000162610.1
 Aig1

androgen-induced 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 59 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 9.5 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.2 8.0 GO:0034605 cellular response to heat(GO:0034605)
0.7 4.1 GO:0009405 pathogenesis(GO:0009405)
0.1 3.7 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 2.6 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.2 2.3 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 2.0 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.2 1.8 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2 1.7 GO:0051014 actin filament severing(GO:0051014)
0.0 1.7 GO:0046847 filopodium assembly(GO:0046847)
0.1 1.4 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 1.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.2 GO:0000266 mitochondrial fission(GO:0000266)
0.4 1.1 GO:0043379 rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.0 1.1 GO:0050919 negative chemotaxis(GO:0050919)
0.0 1.1 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 1.0 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.3 0.9 GO:1904431 positive regulation of t-circle formation(GO:1904431)
0.2 0.9 GO:0010040 response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468)
0.1 0.9 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 9.5 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 3.7 GO:0031594 neuromuscular junction(GO:0031594)
0.1 3.6 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 2.9 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 2.3 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 1.8 GO:0031430 M band(GO:0031430)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.4 1.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.2 0.9 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 0.9 GO:0048476 Holliday junction resolvase complex(GO:0048476)
0.1 0.9 GO:0031209 SCAR complex(GO:0031209)
0.2 0.8 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 0.8 GO:0070187 telosome(GO:0070187)
0.1 0.8 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.7 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 0.5 GO:0042629 mast cell granule(GO:0042629)
0.1 0.5 GO:0089701 U2AF(GO:0089701)
0.0 0.5 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.6 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.0 7.1 GO:0005516 calmodulin binding(GO:0005516)
0.1 2.9 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 2.3 GO:0031402 sodium ion binding(GO:0031402)
0.0 2.3 GO:0019003 GDP binding(GO:0019003)
0.0 1.8 GO:0030507 spectrin binding(GO:0030507)
0.1 1.7 GO:0005522 profilin binding(GO:0005522)
0.1 1.7 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.6 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 1.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 1.3 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 1.2 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 1.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.3 1.0 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.2 1.0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.3 0.9 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 0.9 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.2 0.9 GO:0050544 arachidonic acid binding(GO:0050544)

Gene overrepresentation in C2:CP category:

Showing 1 to 11 of 11 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.9 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 2.8 PID_MET_PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 2.3 PID_CDC42_REG_PATHWAY Regulation of CDC42 activity
0.0 1.9 NABA_ECM_AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.5 PID_TELOMERASE_PATHWAY Regulation of Telomerase
0.0 1.1 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.9 PID_ALPHA_SYNUCLEIN_PATHWAY Alpha-synuclein signaling
0.0 0.8 PID_PI3KCI_PATHWAY Class I PI3K signaling events
0.0 0.7 PID_RAC1_PATHWAY RAC1 signaling pathway
0.0 0.5 ST_GRANULE_CELL_SURVIVAL_PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 0.3 PID_EPHA_FWDPATHWAY EPHA forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 2.9 REACTOME_OLFACTORY_SIGNALING_PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 2.0 REACTOME_RAP1_SIGNALLING Genes involved in Rap1 signalling
0.0 1.7 REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK Genes involved in NRAGE signals death through JNK
0.1 1.5 REACTOME_HYALURONAN_METABOLISM Genes involved in Hyaluronan metabolism
0.2 1.3 REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.1 REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.9 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.8 REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.8 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.0 0.8 REACTOME_PACKAGING_OF_TELOMERE_ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.7 REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 0.6 REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.6 REACTOME_AMYLOIDS Genes involved in Amyloids
0.0 0.6 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.6 REACTOME_HS_GAG_BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0 0.5 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.5 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.5 REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.4 REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)