Motif ID: Tbx21
Z-value: 1.138
Transcription factors associated with Tbx21:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Tbx21 | ENSMUSG00000001444.2 | Tbx21 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.1 | GO:0009405 | pathogenesis(GO:0009405) |
| 0.6 | 9.5 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.4 | 1.1 | GO:0043379 | rRNA export from nucleus(GO:0006407) memory T cell differentiation(GO:0043379) response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) |
| 0.3 | 0.9 | GO:1904431 | positive regulation of t-circle formation(GO:1904431) |
| 0.3 | 0.8 | GO:0090004 | positive regulation of Golgi to plasma membrane protein transport(GO:0042998) positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.3 | 0.8 | GO:2001206 | positive regulation of osteoclast development(GO:2001206) |
| 0.3 | 0.8 | GO:1904742 | regulation of telomeric DNA binding(GO:1904742) |
| 0.2 | 2.3 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.2 | 0.9 | GO:0010040 | response to iron(II) ion(GO:0010040) positive regulation of hydrogen peroxide metabolic process(GO:0010726) negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) regulation of peroxidase activity(GO:2000468) |
| 0.2 | 1.8 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.2 | 0.8 | GO:1903860 | negative regulation of dendrite extension(GO:1903860) regulation of neuron remodeling(GO:1904799) negative regulation of neuron remodeling(GO:1904800) |
| 0.2 | 0.7 | GO:0046391 | 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391) |
| 0.2 | 0.5 | GO:0035021 | negative regulation of Rac protein signal transduction(GO:0035021) |
| 0.2 | 1.7 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.2 | 0.6 | GO:1902268 | negative regulation of polyamine transmembrane transport(GO:1902268) |
| 0.2 | 8.0 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.1 | 0.4 | GO:0051715 | cytolysis in other organism(GO:0051715) |
| 0.1 | 0.5 | GO:0033030 | negative regulation of neutrophil apoptotic process(GO:0033030) |
| 0.1 | 0.6 | GO:0032796 | uropod organization(GO:0032796) |
| 0.1 | 0.4 | GO:1903722 | regulation of centriole elongation(GO:1903722) |
| 0.1 | 0.7 | GO:0071955 | recycling endosome to Golgi transport(GO:0071955) |
| 0.1 | 0.5 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.1 | 0.9 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.1 | 0.6 | GO:0097473 | cellular response to light intensity(GO:0071484) cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
| 0.1 | 0.3 | GO:0045829 | negative regulation of isotype switching(GO:0045829) |
| 0.1 | 0.6 | GO:0006561 | proline biosynthetic process(GO:0006561) |
| 0.1 | 0.5 | GO:2001012 | mesenchymal cell differentiation involved in kidney development(GO:0072161) mesenchymal cell differentiation involved in renal system development(GO:2001012) |
| 0.1 | 0.9 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
| 0.1 | 0.9 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 0.7 | GO:1901407 | regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) |
| 0.1 | 0.5 | GO:1904781 | positive regulation of protein localization to centrosome(GO:1904781) |
| 0.1 | 3.7 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.1 | 0.7 | GO:1900113 | negative regulation of histone H3-K9 trimethylation(GO:1900113) |
| 0.1 | 0.3 | GO:1905247 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) positive regulation of aspartic-type peptidase activity(GO:1905247) |
| 0.1 | 0.8 | GO:0021957 | corticospinal tract morphogenesis(GO:0021957) |
| 0.1 | 0.4 | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) |
| 0.1 | 1.4 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.0 | 0.4 | GO:0006390 | transcription from mitochondrial promoter(GO:0006390) |
| 0.0 | 0.3 | GO:0060700 | regulation of ribonuclease activity(GO:0060700) |
| 0.0 | 2.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 1.0 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 0.9 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.0 | 1.1 | GO:0050919 | negative chemotaxis(GO:0050919) |
| 0.0 | 0.6 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.6 | GO:0045727 | positive regulation of translation(GO:0045727) |
| 0.0 | 0.2 | GO:0045217 | cell-cell junction maintenance(GO:0045217) |
| 0.0 | 1.2 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.0 | 1.7 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 0.1 | GO:0006624 | vacuolar protein processing(GO:0006624) |
| 0.0 | 1.3 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 0.1 | GO:0070072 | vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072) |
| 0.0 | 0.8 | GO:0006360 | transcription from RNA polymerase I promoter(GO:0006360) |
| 0.0 | 0.3 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 1.1 | GO:0055072 | iron ion homeostasis(GO:0055072) |
| 0.0 | 0.9 | GO:0060113 | inner ear receptor cell differentiation(GO:0060113) |
| 0.0 | 2.0 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 0.0 | 0.4 | GO:0014047 | glutamate secretion(GO:0014047) |
| 0.0 | 0.6 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.1 | GO:0000395 | mRNA 5'-splice site recognition(GO:0000395) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.1 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.2 | 0.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 0.9 | GO:0048476 | Holliday junction resolvase complex(GO:0048476) |
| 0.2 | 0.8 | GO:0000120 | RNA polymerase I transcription factor complex(GO:0000120) |
| 0.2 | 2.3 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 0.8 | GO:0070187 | telosome(GO:0070187) |
| 0.1 | 9.5 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 0.8 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 0.9 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.1 | 0.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 1.8 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 2.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.5 | GO:0089701 | U2AF(GO:0089701) |
| 0.1 | 3.6 | GO:0045335 | phagocytic vesicle(GO:0045335) |
| 0.0 | 0.8 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 3.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.4 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 0.3 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 0.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.3 | GO:0000347 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.0 | 0.7 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 0.1 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 0.5 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.0 | 1.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0008392 | arachidonic acid epoxygenase activity(GO:0008392) |
| 0.3 | 0.9 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.2 | 0.7 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.2 | 0.9 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 0.2 | 0.5 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) C-X-C chemokine binding(GO:0019958) |
| 0.2 | 0.6 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.2 | 1.0 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.2 | 0.6 | GO:0004735 | pyrroline-5-carboxylate reductase activity(GO:0004735) |
| 0.2 | 0.9 | GO:0050544 | arachidonic acid binding(GO:0050544) |
| 0.1 | 1.7 | GO:0005522 | profilin binding(GO:0005522) |
| 0.1 | 0.5 | GO:0047237 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047238) |
| 0.1 | 2.3 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.1 | 2.9 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.1 | 0.6 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.1 | 0.4 | GO:0042834 | peptidoglycan binding(GO:0042834) |
| 0.1 | 0.8 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.1 | 1.3 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 0.4 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.1 | 0.8 | GO:0071253 | connexin binding(GO:0071253) |
| 0.1 | 0.4 | GO:0000179 | rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) |
| 0.1 | 1.4 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 0.9 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.1 | 0.4 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) |
| 0.1 | 1.1 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 0.6 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.1 | 1.7 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.8 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 0.0 | 1.8 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.5 | GO:0030628 | pre-mRNA 3'-splice site binding(GO:0030628) |
| 0.0 | 0.2 | GO:0051185 | coenzyme transporter activity(GO:0051185) |
| 0.0 | 2.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.7 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 7.1 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 1.3 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.0 | 0.4 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.0 | 1.2 | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity(GO:0003755) |
| 0.0 | 0.8 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 0.0 | 0.6 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 0.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.5 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 1.6 | GO:0042626 | ATPase activity, coupled to transmembrane movement of substances(GO:0042626) |
| 0.0 | 0.1 | GO:0044547 | DNA topoisomerase binding(GO:0044547) |
| 0.0 | 0.6 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.0 | 0.5 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 9.6 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.0 | 0.3 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
| 0.0 | 1.2 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 0.2 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 2.9 | PID_LPA4_PATHWAY | LPA4-mediated signaling events |
| 0.0 | 2.3 | PID_CDC42_REG_PATHWAY | Regulation of CDC42 activity |
| 0.0 | 0.9 | PID_ALPHA_SYNUCLEIN_PATHWAY | Alpha-synuclein signaling |
| 0.0 | 2.8 | PID_MET_PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.0 | 0.8 | PID_PI3KCI_PATHWAY | Class I PI3K signaling events |
| 0.0 | 1.5 | PID_TELOMERASE_PATHWAY | Regulation of Telomerase |
| 0.0 | 1.1 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.5 | ST_GRANULE_CELL_SURVIVAL_PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 0.3 | PID_EPHA_FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.9 | NABA_ECM_AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.7 | PID_RAC1_PATHWAY | RAC1 signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.9 | REACTOME_OLFACTORY_SIGNALING_PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 1.3 | REACTOME_CYTOSOLIC_SULFONATION_OF_SMALL_MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 1.5 | REACTOME_HYALURONAN_METABOLISM | Genes involved in Hyaluronan metabolism |
| 0.1 | 1.1 | REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.1 | 2.0 | REACTOME_RAP1_SIGNALLING | Genes involved in Rap1 signalling |
| 0.0 | 0.6 | REACTOME_NEGATIVE_REGULATION_OF_THE_PI3K_AKT_NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 0.7 | REACTOME_GLYCOGEN_BREAKDOWN_GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 0.8 | REACTOME_AMINO_ACID_SYNTHESIS_AND_INTERCONVERSION_TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.0 | 0.8 | REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION | Genes involved in RNA Polymerase I Transcription Termination |
| 0.0 | 0.4 | REACTOME_CLASS_C_3_METABOTROPIC_GLUTAMATE_PHEROMONE_RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 0.6 | REACTOME_AMYLOIDS | Genes involved in Amyloids |
| 0.0 | 0.5 | REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.0 | 0.5 | REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 1.7 | REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.5 | REACTOME_CHEMOKINE_RECEPTORS_BIND_CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.0 | 0.8 | REACTOME_PACKAGING_OF_TELOMERE_ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.0 | 0.6 | REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.0 | 0.6 | REACTOME_HS_GAG_BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.0 | 0.9 | REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 0.4 | REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.0 | 0.6 | REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
