Motif ID: Zic3

Z-value: 0.891


Transcription factors associated with Zic3:

Gene SymbolEntrez IDGene Name
Zic3 ENSMUSG00000067860.5 Zic3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zic3mm10_v2_chrX_+_58030622_580306430.302.3e-01Click!


Activity profile for motif Zic3.

activity profile for motif Zic3


Sorted Z-values histogram for motif Zic3

Sorted Z-values for motif Zic3



Network of associatons between targets according to the STRING database.



First level regulatory network of Zic3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_29984219 1.505 ENSMUST00000146092.1
 E2f3
E2F transcription factor 3
chr7_+_127800604 1.144 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
 Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chrX_+_71050160 0.991 ENSMUST00000082088.3
ENSMUST00000114629.3
 Mamld1

mastermind-like domain containing 1

chr13_+_44729535 0.984 ENSMUST00000174068.1
 Jarid2
jumonji, AT rich interactive domain 2
chr1_+_166254095 0.936 ENSMUST00000111416.1
 Ildr2
immunoglobulin-like domain containing receptor 2
chr12_+_3806513 0.837 ENSMUST00000172719.1
 Dnmt3a
DNA methyltransferase 3A
chr17_+_86963279 0.790 ENSMUST00000139344.1
 Rhoq
ras homolog gene family, member Q
chr5_-_115436508 0.706 ENSMUST00000078701.3
 4930430O22Rik
RIKEN cDNA 4930430O22 gene
chr5_+_139543889 0.704 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr8_+_127064107 0.703 ENSMUST00000162536.1
ENSMUST00000026921.6
ENSMUST00000162665.1
ENSMUST00000160766.1
ENSMUST00000162602.1
ENSMUST00000162531.1
ENSMUST00000160581.1
ENSMUST00000161355.1
ENSMUST00000159537.1
 Pard3








par-3 (partitioning defective 3) homolog (C. elegans)








chrX_+_73639414 0.694 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr7_-_49636847 0.688 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr13_-_95891905 0.680 ENSMUST00000068603.6
 Iqgap2
IQ motif containing GTPase activating protein 2
chr8_+_4248188 0.680 ENSMUST00000110993.1
 Gm14378
predicted gene 14378
chr1_-_119053339 0.674 ENSMUST00000161301.1
ENSMUST00000161451.1
ENSMUST00000162607.1
 Gli2


GLI-Kruppel family member GLI2


chr8_-_18950932 0.670 ENSMUST00000055503.5
ENSMUST00000095438.3
 Xkr5

X Kell blood group precursor-related family, member 5

chr7_+_73391160 0.641 ENSMUST00000128471.1
 Rgma
RGM domain family, member A
chr14_+_25607797 0.637 ENSMUST00000160229.1
 Zmiz1
zinc finger, MIZ-type containing 1
chrX_+_56454871 0.637 ENSMUST00000039374.2
ENSMUST00000101553.2
 Ddx26b

DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B

chr12_-_111813834 0.633 ENSMUST00000021715.5
 Xrcc3
X-ray repair complementing defective repair in Chinese hamster cells 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 140 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.3 1.6 GO:0003383 apical constriction(GO:0003383)
0.3 1.5 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.2 1.4 GO:0035754 B cell chemotaxis(GO:0035754)
0.2 1.3 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 1.0 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.2 0.8 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.2 0.8 GO:0055099 response to high density lipoprotein particle(GO:0055099)
0.0 0.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.8 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835) negative regulation of protein complex disassembly(GO:0043242) negative regulation of protein depolymerization(GO:1901880)
0.0 0.8 GO:0031016 pancreas development(GO:0031016)
0.0 0.8 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.2 0.7 GO:0060032 notochord regression(GO:0060032)
0.1 0.7 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
0.1 0.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.7 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.1 0.7 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 0.6 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 44 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.6 GO:0033269 internode region of axon(GO:0033269)
0.1 1.6 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.3 GO:0001741 XY body(GO:0001741)
0.1 0.8 GO:0016011 dystroglycan complex(GO:0016011)
0.1 0.7 GO:0001940 male pronucleus(GO:0001940)
0.1 0.7 GO:0097542 ciliary tip(GO:0097542)
0.0 0.7 GO:0042555 MCM complex(GO:0042555)
0.0 0.7 GO:0031941 filamentous actin(GO:0031941)
0.1 0.6 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.6 GO:0097539 ciliary transition fiber(GO:0097539)
0.0 0.5 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.5 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 0.4 GO:0060091 kinocilium(GO:0060091)
0.0 0.4 GO:0097165 nuclear stress granule(GO:0097165)
0.0 0.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 0.3 GO:0098536 deuterosome(GO:0098536)
0.1 0.3 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 0.3 GO:0016035 zeta DNA polymerase complex(GO:0016035)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.2 GO:0001047 core promoter binding(GO:0001047)
0.0 1.6 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.2 1.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 1.3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 1.3 GO:0032452 histone demethylase activity(GO:0032452)
0.1 1.1 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 1.0 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.9 GO:0004300 enoyl-CoA hydratase activity(GO:0004300)
0.1 0.8 GO:0043237 laminin-1 binding(GO:0043237)
0.1 0.8 GO:0005522 profilin binding(GO:0005522)
0.1 0.7 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.6 GO:0000150 recombinase activity(GO:0000150)
0.1 0.6 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.0 0.6 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.6 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.6 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)

Gene overrepresentation in C2:CP category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.1 NABA_ECM_REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 1.5 PID_RB_1PATHWAY Regulation of retinoblastoma protein
0.2 1.1 ST_PAC1_RECEPTOR_PATHWAY PAC1 Receptor Pathway
0.0 1.0 PID_PLK1_PATHWAY PLK1 signaling events
0.0 0.8 PID_INSULIN_GLUCOSE_PATHWAY Insulin-mediated glucose transport
0.0 0.7 PID_ANTHRAX_PATHWAY Cellular roles of Anthrax toxin
0.0 0.7 PID_HEDGEHOG_2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.7 PID_HIF1_TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.7 PID_MYC_REPRESS_PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.7 PID_SMAD2_3NUCLEAR_PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.6 PID_FANCONI_PATHWAY Fanconi anemia pathway
0.0 0.6 PID_ATR_PATHWAY ATR signaling pathway
0.0 0.5 PID_ALK2_PATHWAY ALK2 signaling events
0.0 0.5 PID_SYNDECAN_2_PATHWAY Syndecan-2-mediated signaling events
0.0 0.4 PID_EPHA2_FWD_PATHWAY EPHA2 forward signaling
0.0 0.4 PID_HIF1A_PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 0.4 PID_PDGFRA_PATHWAY PDGFR-alpha signaling pathway
0.0 0.4 PID_HEDGEHOG_GLI_PATHWAY Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in C2:CP:REACTOME category:

Showing 1 to 20 of 24 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.6 REACTOME_TGF_BETA_RECEPTOR_SIGNALING_IN_EMT_EPITHELIAL_TO_MESENCHYMAL_TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 1.5 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.2 1.4 REACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 1.0 REACTOME_NOTCH_HLH_TRANSCRIPTION_PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 1.0 REACTOME_GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 0.7 REACTOME_UNWINDING_OF_DNA Genes involved in Unwinding of DNA
0.1 0.6 REACTOME_RECEPTOR_LIGAND_BINDING_INITIATES_THE_SECOND_PROTEOLYTIC_CLEAVAGE_OF_NOTCH_RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0 0.6 REACTOME_CASPASE_MEDIATED_CLEAVAGE_OF_CYTOSKELETAL_PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.5 REACTOME_DOWNREGULATION_OF_SMAD2_3_SMAD4_TRANSCRIPTIONAL_ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0 0.5 REACTOME_METAL_ION_SLC_TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.5 REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.4 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 0.4 REACTOME_JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0 0.3 REACTOME_NFKB_ACTIVATION_THROUGH_FADD_RIP1_PATHWAY_MEDIATED_BY_CASPASE_8_AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.3 REACTOME_HORMONE_SENSITIVE_LIPASE_HSL_MEDIATED_TRIACYLGLYCEROL_HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.3 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 0.2 REACTOME_ACTIVATION_OF_RAC Genes involved in Activation of Rac
0.0 0.2 REACTOME_MTORC1_MEDIATED_SIGNALLING Genes involved in mTORC1-mediated signalling