Motif ID: Gbx2

Z-value: 0.516


Transcription factors associated with Gbx2:

Gene SymbolEntrez IDGene Name
Gbx2 ENSMUSG00000034486.7 Gbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Gbx2mm10_v2_chr1_-_89933290_899332900.437.5e-02Click!


Activity profile for motif Gbx2.

activity profile for motif Gbx2


Sorted Z-values histogram for motif Gbx2

Sorted Z-values for motif Gbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Gbx2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_48667508 2.891 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr3_+_94372794 2.009 ENSMUST00000029795.3
 Rorc
RAR-related orphan receptor gamma
chr11_+_59306920 1.834 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr17_-_48432723 1.628 ENSMUST00000046549.3
 Apobec2
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
chr12_+_79297345 1.179 ENSMUST00000079533.5
ENSMUST00000171210.1
 Rad51b

RAD51 homolog B

chr3_-_116129615 0.962 ENSMUST00000029574.8
 Vcam1
vascular cell adhesion molecule 1
chr2_+_27079371 0.951 ENSMUST00000091233.6
 Adamtsl2
ADAMTS-like 2
chr7_-_30664986 0.908 ENSMUST00000019697.8
 Haus5
HAUS augmin-like complex, subunit 5
chrX_+_106920618 0.731 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr13_+_23763660 0.706 ENSMUST00000055770.1
 Hist1h1a
histone cluster 1, H1a
chr7_-_78783026 0.695 ENSMUST00000032841.5
 Mrpl46
mitochondrial ribosomal protein L46
chrM_-_14060 0.666 ENSMUST00000082419.1
 mt-Nd6
mitochondrially encoded NADH dehydrogenase 6
chr19_-_59170978 0.645 ENSMUST00000172821.2
 Vax1
ventral anterior homeobox containing gene 1
chr3_-_141982224 0.639 ENSMUST00000029948.8
 Bmpr1b
bone morphogenetic protein receptor, type 1B
chr1_-_128102412 0.609 ENSMUST00000112538.1
ENSMUST00000086614.5
 Zranb3

zinc finger, RAN-binding domain containing 3

chr4_-_129261394 0.581 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr7_+_75455534 0.574 ENSMUST00000147005.1
ENSMUST00000166315.1
 Akap13

A kinase (PRKA) anchor protein 13

chr1_+_71652837 0.573 ENSMUST00000097699.2
 Apol7d
apolipoprotein L 7d
chr10_-_95501921 0.541 ENSMUST00000075829.2
 Mrpl42
mitochondrial ribosomal protein L42
chr11_-_5878207 0.535 ENSMUST00000102922.3
 Pold2
polymerase (DNA directed), delta 2, regulatory subunit
chr11_-_21370452 0.465 ENSMUST00000102875.4
 Ugp2
UDP-glucose pyrophosphorylase 2
chr10_+_128083273 0.451 ENSMUST00000026459.5
 Atp5b
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
chr7_+_28810886 0.443 ENSMUST00000038572.8
 Hnrnpl
heterogeneous nuclear ribonucleoprotein L
chr11_+_97315716 0.421 ENSMUST00000019026.3
ENSMUST00000132168.1
 Mrpl45

mitochondrial ribosomal protein L45

chr3_-_89998656 0.418 ENSMUST00000079724.4
 Hax1
HCLS1 associated X-1
chr13_+_49544443 0.415 ENSMUST00000177948.1
ENSMUST00000021820.6
 Aspn

asporin

chr1_-_175625580 0.401 ENSMUST00000027810.7
 Fh1
fumarate hydratase 1
chr14_+_58893465 0.383 ENSMUST00000079960.1
 Rpl13-ps3
ribosomal protein L13, pseudogene 3
chr1_-_4785671 0.380 ENSMUST00000130201.1
ENSMUST00000156816.1
 Mrpl15

mitochondrial ribosomal protein L15

chrX_-_56598069 0.365 ENSMUST00000059899.2
 Mmgt1
membrane magnesium transporter 1
chr8_-_21906412 0.364 ENSMUST00000051965.4
 Defb11
defensin beta 11
chr7_+_78783119 0.345 ENSMUST00000032840.4
 Mrps11
mitochondrial ribosomal protein S11
chr3_-_10331358 0.318 ENSMUST00000065938.8
ENSMUST00000118410.1
 Impa1

inositol (myo)-1(or 4)-monophosphatase 1

chr3_+_96645579 0.315 ENSMUST00000119365.1
ENSMUST00000029744.5
 Itga10

integrin, alpha 10

chr3_+_152714094 0.305 ENSMUST00000159899.1
ENSMUST00000045029.8
 Pigk

phosphatidylinositol glycan anchor biosynthesis, class K

chr12_+_111814170 0.299 ENSMUST00000021714.7
 Zfyve21
zinc finger, FYVE domain containing 21
chr5_+_115341225 0.283 ENSMUST00000031508.4
 Triap1
TP53 regulated inhibitor of apoptosis 1
chr14_+_69347587 0.276 ENSMUST00000064831.5
 Entpd4
ectonucleoside triphosphate diphosphohydrolase 4
chr2_+_152754156 0.246 ENSMUST00000010020.5
 Cox4i2
cytochrome c oxidase subunit IV isoform 2
chr19_+_23723279 0.233 ENSMUST00000067077.1
 Gm9938
predicted gene 9938
chr2_-_160619971 0.219 ENSMUST00000109473.1
 Gm14221
predicted gene 14221
chr18_+_56432116 0.195 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr1_-_24005608 0.147 ENSMUST00000027338.3
 1110058L19Rik
RIKEN cDNA 1110058L19 gene
chr4_+_110397764 0.142 ENSMUST00000097920.2
ENSMUST00000080744.6
 Agbl4

ATP/GTP binding protein-like 4

chr16_+_44394771 0.138 ENSMUST00000099742.2
 Wdr52
WD repeat domain 52
chr14_-_66213552 0.138 ENSMUST00000178730.1
 Ptk2b
PTK2 protein tyrosine kinase 2 beta
chr13_-_97747373 0.117 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr2_-_157566319 0.104 ENSMUST00000109528.2
ENSMUST00000088494.2
 Blcap

bladder cancer associated protein homolog (human)

chr9_+_96258697 0.080 ENSMUST00000179416.1
 Tfdp2
transcription factor Dp 2
chr5_-_5266038 0.073 ENSMUST00000115451.1
ENSMUST00000115452.1
ENSMUST00000131392.1
 Cdk14


cyclin-dependent kinase 14


chr11_-_45955183 0.069 ENSMUST00000109254.1
 Thg1l
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr19_-_32196393 0.054 ENSMUST00000151822.1
 Sgms1
sphingomyelin synthase 1
chr17_+_84956718 0.052 ENSMUST00000112305.3
 Ppm1b
protein phosphatase 1B, magnesium dependent, beta isoform
chr18_+_57354733 0.029 ENSMUST00000025490.8
 Prrc1
proline-rich coiled-coil 1
chr5_-_115341142 0.023 ENSMUST00000139167.1
 Gatc
glutamyl-tRNA(Gln) amidotransferase, subunit C homolog (bacterial)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.9 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 1.6 GO:0016554 cytidine to uridine editing(GO:0016554)
0.3 2.0 GO:0072615 interleukin-17 secretion(GO:0072615)
0.2 0.6 GO:0036292 DNA rewinding(GO:0036292)
0.2 1.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.2 0.6 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.2 0.5 GO:0006011 UDP-glucose metabolic process(GO:0006011) glucose 1-phosphate metabolic process(GO:0019255)
0.1 0.4 GO:0006106 fumarate metabolic process(GO:0006106)
0.1 0.5 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.1 0.6 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.1 1.0 GO:0061032 visceral serous pericardium development(GO:0061032)
0.1 0.4 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.1 0.6 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.1 1.8 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 1.0 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.1 0.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.1 GO:0010752 signal complex assembly(GO:0007172) regulation of cGMP-mediated signaling(GO:0010752)
0.0 0.4 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.5 GO:0006271 DNA strand elongation involved in DNA replication(GO:0006271)
0.0 0.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.4 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.3 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.3 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.0 0.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.4 GO:0000002 mitochondrial genome maintenance(GO:0000002)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.2 0.5 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.9 GO:0070652 HAUS complex(GO:0070652)
0.1 0.3 GO:0097637 intrinsic component of autophagosome membrane(GO:0097636) integral component of autophagosome membrane(GO:0097637)
0.1 0.5 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 0.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 2.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.4 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.4 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.4 GO:0045120 pronucleus(GO:0045120)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.6 GO:0043596 nuclear replication fork(GO:0043596)
0.0 0.3 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 3.0 GO:0030426 growth cone(GO:0030426)
0.0 0.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.7 GO:0070469 respiratory chain(GO:0070469)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0008142 oxysterol binding(GO:0008142)
0.4 1.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.2 1.0 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 1.0 GO:0050436 microfibril binding(GO:0050436)
0.2 1.2 GO:0000150 recombinase activity(GO:0000150)
0.1 0.4 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.3 GO:0031403 lithium ion binding(GO:0031403)
0.1 0.7 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.3 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
0.1 0.5 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.6 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 0.3 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1 0.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.3 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.1 0.6 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.8 GO:0005109 frizzled binding(GO:0005109)
0.0 0.4 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.0 0.4 GO:1990715 mRNA CDS binding(GO:1990715)
0.0 0.5 GO:0070569 pyrimidine ribonucleotide binding(GO:0032557) uridylyltransferase activity(GO:0070569)
0.0 0.3 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.0 0.3 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 2.9 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 PID_INTEGRIN2_PATHWAY Beta2 integrin cell surface interactions
0.0 0.7 PID_LPA4_PATHWAY LPA4-mediated signaling events
0.0 0.3 PID_INTEGRIN_CS_PATHWAY Integrin family cell surface interactions
0.0 1.8 WNT_SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.6 PID_BMP_PATHWAY BMP receptor signaling
0.0 0.4 NABA_PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME_P2Y_RECEPTORS Genes involved in P2Y receptors
0.1 0.5 REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.1 0.5 REACTOME_GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.7 REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 1.0 REACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 2.0 REACTOME_NUCLEAR_RECEPTOR_TRANSCRIPTION_PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 1.8 REACTOME_CLASS_B_2_SECRETIN_FAMILY_RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.6 REACTOME_SIGNALING_BY_BMP Genes involved in Signaling by BMP